Drug & supplement interaction

Job's Tears + Binimetinib

Binimetinib brand name: Mektovi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Job's Tears and Binimetinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Job's Tears and Binimetinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Binimetinib and Job's Tears in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Job's Tears safety at a glance

Job's Tears overall Use caution Generally safe as a cooked food, but concentrated supplement evidence is limited.
Pregnancy Avoid Traditionally avoided in pregnancy and human safety data are lacking.
Breastfeeding Use caution Not enough reliable data; use only ordinary food amounts and check with a clinician.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Binimetinib and Job's Tears? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Binimetinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Binimetinib is filed under 2 classifications — hepatotoxic drugs, oral drugs. Job's Tears has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), chlorzoxazone (parafon forte, paraflex) (moderate) and dextromethorphan (robitussin dm, others) (moderate) — and none of Binimetinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Job's Tears Does Interact With Other Medications

Job's Tears has 128 moderate known drug interactions in our database — Binimetinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 128 No known interaction 2,702 (incl. Binimetinib)
Taking anything else?

Check Another of Your Medications Against Job's Tears

Covers the 2,830 medications we’ve checked against Job's Tears. Pick one to open its full report.

What to actually watch for

What Binimetinib’s Own FDA Label Lists

This is not an interaction — none of it involves Job's Tears. These are the most notable effects listed in the ADVERSE REACTIONS section of Binimetinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on
  • Unsteadiness Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Heart failure Worth acting on
  • An irregular heartbeat Worth acting on
  • Chest pain Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on

Showing the 10 most notable of 39 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Binimetinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 7,756 voluntary FDA FAERS reports for Binimetinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Job's Tears’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Job's Tears side to compare — that is a limit of the record, not a statement that Job's Tears has no side effects.

From our Q&A

Questions About Job's Tears or Binimetinib

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Job's Tears or Binimetinib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Binimetinib

This page covers Job's Tears only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Binimetinib page lists 55 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 42 moderate · 9 minor.

From our pharmacist’s overview on the Binimetinib page

“Binimetinib (Mektovi) is a targeted cancer drug for melanoma, and this list warrants genuine care before you mix in supplements. Of the 55 herbal and supplement ingredients on file, 38 share one core problem: they can stress the liver, and layering them onto a medication your liver is already processing raises the risk of real damage.”

Reviewed by 2 · Jul 18, 2026

Open the Binimetinib interaction page

One more smart check

Taking Job's Tears as Part of a Dietary Supplement Product? Check It for Interactions

We hold 111 real supplement products containing Job's Tears, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Job's Tears. Even though Job's Tears itself has no known interaction with Binimetinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Job's Tears and Binimetinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Job's Tears
Steady interest

#795 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Binimetinib
Top half

#1,263 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Job's Tears reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Job's Tears and Binimetinib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Job's Tears

What is Job's Tears?

  • Digestive support
  • Skin health and smoothness
  • Mild swelling or water retention
  • General nourishing food/tonic
  • Joint discomfort (traditional use)

Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia. While it is generally safe as a food and is being studied for possible effects on metabolism, inflammation, and immunity, strong human evidence for its health claims is limited. Talk with your pharmacist or doctor before using concentrated supplements, especially during pregnancy.

Coix lacryma-jobi · Poaceae · Seeds (grain/kernel), sometimes root · Whole grain, cooked food, tea, powder, capsules, flour

An interaction check asks whether these two react with each other — it does not ask whether Job's Tears is a good idea for someone in your situation. Here is what our Job's Tears record says about it on its own.

Job's Tears: dosing

There is no established standardized dose for Job's Tears as a supplement. As a food, it is simply cooked and eaten like other whole grains.For capsules, powders, or teas, follow the directions on the product label, since strengths vary widely between products.

From our Job's Tears monograph — the full record covers uses, side effects and every documented interaction.

Read the full Job's Tears monograph & all interactions
Medication

About Binimetinib

What Is Binimetinib Used For?

Brand name: Mektovi

Mektovi (binimetinib) is used in combination with another medicine called encorafenib. Together, they treat unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) melanoma in patients whose tumors have a BRAF V600E or V600K mutation, as confirmed by an FDA-approved test.

Mektovi, used with encorafenib, is also approved for adult patients with metastatic non-small cell lung cancer (NSCLC) that carries a BRAF V600E mutation, again confirmed by an FDA-approved test. In both cases, testing for the specific mutation is required before starting treatment.

Most-Reported Side Effects for Binimetinib

From FAERS, the FDA’s public side-effect reporting system (7,756 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 715 reports
Fatigue 604 reports
Diarrhea 570 reports
Fever 542 reports
Vomiting 415 reports
See full Binimetinib drug information
Keep checking

Other Drugs & Job's Tears

Browse every other medication we’ve checked against Job's Tears — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
128Moderate
0Minor
2,701No known interaction
128 Moderate 2,701 No interaction
Moderate

128 interactions

Showing 60 of 128 moderate interactions — see all 128 on the Job's Tears page.

No interaction 2,701 drugs checked — show the list

We also checked Job's Tears against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,701 medications checked with no known interaction — see the full Job's Tears list.

See the full Job's Tears interactions page
See every supplement checked against Binimetinib, ranked by severity
Evidence & sources

Job's Tears References

The 3 references that drive our Job's Tears monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chiang W, Cheng C, Chiang M, Chung KT. Effects of dehulled adlay on the culture count of some microbiota and their metabolism in the gastrointestinal tract of rats. J Agric Food Chem 2000;48:829-32. PubMed
  2. Yu YM, Chang WC, Liu CS, Tsai CM. Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers. Biol Pharm Bull 2004;27:802-5. PubMed
  3. Yao HT, Lin JH, Liu YT, Li ML, Chiang W. Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients 2019;11(10):2473. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Job's Tears and Binimetinib Together: Common Questions

Is it safe to take Job's Tears with Binimetinib?
We do not list a known interaction between Job's Tears and Binimetinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Job's Tears and Binimetinib combination checked?
Interactions in our licensed database are recorded against drug classes. Binimetinib is filed under 2 classifications, and Job's Tears has documented interactions with 5 drug classes — none of Binimetinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Job's Tears interact with any other medications?
Yes. Job's Tears has 128 documented drug interactions in our database — Binimetinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Binimetinib interact with any supplements?
Yes. Binimetinib has documented interactions with 55 supplements in our database — Job's Tears is not one of them. The Binimetinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Job's Tears monograph Uses, safety profile, and every drug interaction in one place Binimetinib drug information The full plain-English guide to this medication Binimetinib supplement interactions Every supplement checked against Binimetinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Binimetinib and Job's Tears?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.