Drug & supplement interaction

Job's Tears + Liotrix

Liotrix brand names: Euthroid 3, Euthroid 1/2, Euthroid 1.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Job's Tears and Liotrix in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Liotrix states a food rule worth keeping to.

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Interaction report

Job's Tears and Liotrix

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Liotrix and Job's Tears in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Job's Tears safety at a glance

Job's Tears overall Use caution Generally safe as a cooked food, but concentrated supplement evidence is limited.

Pregnancy Avoid Traditionally avoided in pregnancy and human safety data are lacking.

Breastfeeding Use caution Not enough reliable data; use only ordinary food amounts and check with a clinician.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Liotrix and Job's Tears? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Liotrix

Interactions in our licensed database are recorded against drug classes, not just single drug names. Liotrix is filed under 2 classifications — thyroid hormone, oral drugs. Job's Tears has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), chlorzoxazone (parafon forte, paraflex) (moderate) and dextromethorphan (robitussin dm, others) (moderate) — and none of Liotrix’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Job's Tears Does Interact With Other Medications

Job's Tears has 128 moderate known drug interactions in our database — Liotrix isn’t one of them. If you take anything else, check it against the full list below.

Moderate 128 No known interaction 2,702 (incl. Liotrix)

Taking anything else?

Check Another of Your Medications Against Job's Tears

Covers the 2,830 medications we’ve checked against Job's Tears. Pick one to open its full report.

What to actually watch for

What Liotrix’s Own FDA Label Lists

This is not an interaction — none of it involves Job's Tears. These are the most notable effects listed in the ADVERSE REACTIONS section of Liotrix’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

A change in thyroid levels Worth acting on
Bone thinning Worth acting on
Muscle weakness Worth acting on
A heart attack Worth acting on
Heart failure Worth acting on
Wheezing Worth acting on
Seizures Worth acting on
Chest pain Worth acting on
Shortness of breath Worth acting on
A severe allergic reaction Worth acting on

Showing the 10 most notable of 32 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed › Job's Tears’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Job's Tears side to compare — that is a limit of the record, not a statement that Job's Tears has no side effects.

How to take them

Some Liotrix Products Have a Food Rule — Job's Tears Should Not Break It

At least one FDA label for a product containing Liotrix says to take it on an empty stomach. Most supplements — Job's Tears included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Liotrix on its own and move Job's Tears to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Liotrix products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Liotrix

This page covers Job's Tears only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liotrix page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 26 moderate · 10 minor.

From our pharmacist’s overview on the Liotrix page

“Liotrix (Euthroid) combines both thyroid hormones, and since steady hormone levels are the entire point of treatment, this list deserves a slow, serious read. Most entries fall into two camps: twenty-one ingredients act on the hormone itself, some boosting it and others blunting it, while another seventeen change how well the dose is a…”

Reviewed by 2 · Jul 18, 2026

Open the Liotrix interaction page

One more smart check

Taking Job's Tears as Part of a Dietary Supplement Product? Check It for Interactions

We hold 111 real supplement products containing Job's Tears, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Job's Tears. Even though Job's Tears itself has no known interaction with Liotrix, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Job's Tears and Liotrix Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Job's Tears

Steady interest

#957 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Liotrix

Top half

#1,277 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Job's Tears reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Job's Tears and Liotrix records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Job's Tears

What is Job's Tears?

Digestive support
Skin health and smoothness
Mild swelling or water retention
General nourishing food/tonic
Joint discomfort (traditional use)

Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia. While it is generally safe as a food and is being studied for possible effects on metabolism, inflammation, and immunity, strong human evidence for its health claims is limited. Talk with your pharmacist or doctor before using concentrated supplements, especially during pregnancy.

Coix lacryma-jobi · Poaceae · Seeds (grain/kernel), sometimes root · Whole grain, cooked food, tea, powder, capsules, flour

An interaction check asks whether these two react with each other — it does not ask whether Job's Tears is a good idea for someone in your situation. Here is what our Job's Tears record says about it on its own.

Job's Tears: dosing

There is no established standardized dose for Job's Tears as a supplement. As a food, it is simply cooked and eaten like other whole grains.For capsules, powders, or teas, follow the directions on the product label, since strengths vary widely between products.

From our Job's Tears monograph — the full record covers uses, side effects and every documented interaction.

Read the full Job's Tears monograph & all interactions

Medication

About Liotrix

What Is Liotrix Used For?

Brand names: Euthroid 3, Euthroid 1/2, Euthroid 1

Liotrix is used to treat hypothyroidism (a condition that results when the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyroidism include lack of energy, depression, constipation, weight gain, hair loss, dry skin, dry coarse hair, muscle cramps, decreased concentration, aches and pains, swelling of the legs, and increased sensitivity to cold. When taken correctly, liotrix can reverse these symptoms. Liotrix is also used to treat goiter (enlarged thyroid gland). This medication is also used to test for hyperthyroidism (a condition where the thyroid gland produces too much thyroid hormone). Liotrix is in a class of medications called thyroid agents. It works by supplying the thyroid hormones normally produced by the body.

See full Liotrix drug information

Keep checking

Other Drugs & Job's Tears

Browse every other medication we’ve checked against Job's Tears — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

128Moderate

0Minor

2,701No known interaction

128 Moderate 2,701 No interaction

Moderate

128 interactions

Showing 60 of 128 moderate interactions — see all 128 on the Job's Tears page.

No interaction 2,701 drugs checked — show the list

We also checked Job's Tears against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,701 medications checked with no known interaction — see the full Job's Tears list.

See the full Job's Tears interactions page

See every supplement checked against Liotrix, ranked by severity

Evidence & sources

Job's Tears References

The 3 references that drive our Job's Tears monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Chiang W, Cheng C, Chiang M, Chung KT. Effects of dehulled adlay on the culture count of some microbiota and their metabolism in the gastrointestinal tract of rats. J Agric Food Chem 2000;48:829-32. PubMed
Yu YM, Chang WC, Liu CS, Tsai CM. Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers. Biol Pharm Bull 2004;27:802-5. PubMed
Yao HT, Lin JH, Liu YT, Li ML, Chiang W. Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients 2019;11(10):2473. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Job's Tears and Liotrix Together: Common Questions

Is it safe to take Job's Tears with Liotrix?

We do not list a known interaction between Job's Tears and Liotrix. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Job's Tears and Liotrix at the same time of day?

At least one FDA label for a product containing Liotrix says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Liotrix on its own and move Job's Tears to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

How was the Job's Tears and Liotrix combination checked?

Interactions in our licensed database are recorded against drug classes. Liotrix is filed under 2 classifications, and Job's Tears has documented interactions with 5 drug classes — none of Liotrix's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Job's Tears interact with any other medications?

Yes. Job's Tears has 128 documented drug interactions in our database — Liotrix is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Liotrix interact with any supplements?

Yes. Liotrix has documented interactions with 38 supplements in our database — Job's Tears is not one of them. The Liotrix interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Job's Tears monograph Uses, safety profile, and every drug interaction in one place Liotrix drug information The full plain-English guide to this medication Liotrix supplement interactions Every supplement checked against Liotrix, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Liotrix and Job's Tears?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.