Drug & supplement interaction

Lactobacillus Crispatus + Vonoprazan, Amoxicillin, Clarithromycin

Vonoprazan, Amoxicillin, Clarithromycin brand name: Voquezna Triple.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Lactobacillus Crispatus has a moderate interaction with Vonoprazan, Amoxicillin, Clarithromycin. Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lactobacillus Crispatus and Vonoprazan, Amoxicillin, Clarithromycin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Vonoprazan, Amoxicillin, Clarithromycin

Vonoprazan, Amoxicillin, Clarithromycin falls under ANTIBIOTIC DRUGS — the group Lactobacillus Crispatus interacts with.

Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L. crispatus.
Lactobacillus crispatus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. crispatus preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know: Voquezna Triple is an antibiotic pack (amoxicillin and clarithromycin) used to knock out an H. pylori stomach infection. The concern runs the other way here. The antibiotics don't get weaker, but they don't tell the difference between bad bugs and the friendly Lactobacillus crispatus in your probiotic. So if you swallow them at the same time, those antibiotics may kill off a good chunk of the live probiotic organisms, leaving you with little benefit from it.

This is a theoretical interaction based on how these drugs work, and it's easy to manage. A common tip is to space the probiotic and your antibiotic doses by at least two hours. Run your full schedule by your pharmacist or doctor so you stay on track with the H. pylori treatment.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lactobacillus Crispatus Also Interacts With Other Medications

Lactobacillus Crispatus has 181 moderate known drug interactions in our database — the Vonoprazan, Amoxicillin, Clarithromycin one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Vonoprazan, Amoxicillin, Clarithromycin)
Taking anything else?

Check Another of Your Medications Against Lactobacillus Crispatus

Covers the 2,830 medications we’ve checked against Lactobacillus Crispatus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Vonoprazan, Amoxicillin, Clarithromycin

This page covers Lactobacillus Crispatus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Vonoprazan, Amoxicillin, Clarithromycin page lists 231 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Asarabacca (major) and Beer (major).

By severity: 13 major · 180 moderate · 38 minor.

From our pharmacist’s overview on the Vonoprazan, Amoxicillin, Clarithromycin page

“Voquezna Triple packs vonoprazan and two antibiotics, amoxicillin and clarithromycin, into a short course against H. pylori, the stomach bacteria behind many ulcers.”

Reviewed by 2 · Jul 18, 2026

Open the Vonoprazan, Amoxicillin, Clarithromycin interaction page

One more smart check

Taking Lactobacillus Crispatus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 48 real supplement products containing Lactobacillus Crispatus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lactobacillus Crispatus. Your product may carry other ingredients that interact with Vonoprazan, Amoxicillin, Clarithromycin too, on top of Lactobacillus Crispatus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lactobacillus Crispatus and Vonoprazan, Amoxicillin, Clarithromycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactobacillus Crispatus
Steady interest

#813 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Vonoprazan, Amoxicillin, Clarithromycin
Top half

#752 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lactobacillus Crispatus

What is Lactobacillus Crispatus?

  • Vaginal health support
  • Preventing recurrent bacterial vaginosis
  • Reducing recurrent urinary tract infections
  • Yeast infection support
  • General microbiome balance

Lactobacillus crispatus is a 'good' bacterium that naturally dominates a healthy vaginal microbiome and is sold as a probiotic, mainly for vaginal and urinary health. Early research is promising for preventing recurrent bacterial vaginosis and urinary tract infections, but evidence is still limited and product quality varies. Talk with your pharmacist or doctor before using it, especially if you are pregnant or have a weakened immune system.

Read the full Lactobacillus Crispatus monograph & all interactions
Keep checking

Other Drugs & Lactobacillus Crispatus

Browse every other medication we’ve checked against Lactobacillus Crispatus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Lactobacillus Crispatus page.

No interaction 2,648 drugs checked — show the list

We also checked Lactobacillus Crispatus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Lactobacillus Crispatus list.

See the full Lactobacillus Crispatus interactions page
See every supplement checked against Vonoprazan, Amoxicillin, Clarithromycin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lactobacillus Crispatus monograph › Uses, safety, and every drug interaction in one place Vonoprazan, Amoxicillin, Clarithromycin supplement interactions › Every supplement checked against Vonoprazan, Amoxicillin, Clarithromycin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lactobacillus Crispatus and Vonoprazan, Amoxicillin, Clarithromycin Together: Common Questions

Can you take Lactobacillus Crispatus with Vonoprazan, Amoxicillin, Clarithromycin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lactobacillus Crispatus and Vonoprazan, Amoxicillin, Clarithromycin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Vonoprazan, Amoxicillin, Clarithromycin and Lactobacillus Crispatus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.