Medication interaction hub

What Supplements Interact with Vonoprazan, Amoxicillin, Clarithromycin?

Vonoprazan, Amoxicillin, Clarithromycin brand name: Voquezna Triple. Every interaction below applies to the brands too.

231 Interactions 13 Major 180 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Vonoprazan, Amoxicillin, Clarithromycin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Vonoprazan, Amoxicillin, Clarithromycin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Voquezna Triple packs vonoprazan and two antibiotics, amoxicillin and clarithromycin, into a short course against H. pylori, the stomach bacteria behind many ulcers. Even for a couple of weeks, I'd handle this list carefully, and the 13 major-rated entries are the ones to understand first. Clarithromycin runs through the same liver enzyme (CYP3A4) that grapefruit blocks and St. John's wort speeds up, so those two everyday items can push its level too high or drain it too low. A cluster of herbs and minerals on this list can also stretch the heart's QT interval, its electrical reset time, alongside clarithromycin.

Alcohol adds strain to a liver already processing these drugs. Probiotics aren't dangerous, but the antibiotics kill them, so space those doses well apart. Most of the 231 entries rate moderate, with 38 minor, yet the majors set the tone here.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 180 Minor 38 No known interaction 1,221

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Vonoprazan, Amoxicillin, Clarithromycin: Top Interactions at a Glance

The Vonoprazan, Amoxicillin, Clarithromycin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 231 interacting ingredients — plus 1,221 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Vonoprazan, Amoxicillin, Clarithromycin Combinations Today

The Vonoprazan, Amoxicillin, Clarithromycin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Lactobacillus Acidophilus + Vonoprazan, Amoxicillin, Clarithromycini

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction Minor Likelihood Possible Caffeine + Vonoprazan, Amoxicillin, Clarithromycini

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Green Tea + Vonoprazan, Amoxicillin, Clarithromycini

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Minor Likelihood Possible Guarana + Vonoprazan, Amoxicillin, Clarithromycini

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Minor Likelihood Possible Vitamin D + Vonoprazan, Amoxicillin, Clarithromycini

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction Major Likelihood Possible Asarabacca + Vonoprazan, Amoxicillin, Clarithromycini

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Vonoprazan, Amoxicillin, Clarithromycin

All 1,452 ingredients in our database, ranked by severity — 231 with a Vonoprazan, Amoxicillin, Clarithromycin interaction on file and 1,221 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Vonoprazan, Amoxicillin, Clarithromycin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Lactobacillus Acidophilus with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Caffeine with Vonoprazan, Amoxicillin, Clarithromycin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Caffeine + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Green Tea with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Green Tea + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Guarana with Vonoprazan, Amoxicillin, Clarithromycin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Guarana + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Vitamin D with Vonoprazan, Amoxicillin, Clarithromycin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Licorice with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Ligandrol with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Lily-of-the-valley with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using lily-of-the-valley with macrolide antibiotics can increase the risk of cardiac glycoside toxicity.

Full Lily-of-the-valley + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Lime with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Full Lime + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Manchurian Thorn with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Melatonin with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Methoxylated Flavones with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Moringa with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Mountain Ash with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Neem with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Niacin with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Noni with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Oolong Tea with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of the caffeine in oolong tea.

Full Oolong Tea + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Oregon Grape with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Vonoprazan, Amoxicillin, Clarithromycin answer

Can you take Ostarine with Vonoprazan, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Vonoprazan, Amoxicillin, Clarithromycin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Vonoprazan, Amoxicillin, Clarithromycin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Vonoprazan, Amoxicillin, Clarithromycin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Vonoprazan, Amoxicillin, Clarithromycin sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Macrolide Antibiotics 11 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

11 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin, Clarithromycin through this category.

Related: does Vonoprazan, Amoxicillin, Clarithromycin deplete any nutrients?

Vonoprazan, Amoxicillin, Clarithromycin has 7 reported nutrient associations in the research literature — see the Vonoprazan, Amoxicillin, Clarithromycin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Vonoprazan, Amoxicillin, Clarithromycin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Vonoprazan, Amoxicillin, Clarithromycin.

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Pharmacist Counseling Corner

Vonoprazan, Amoxicillin, Clarithromycin & Supplements: Common Questions

What supplements interact with Vonoprazan, Amoxicillin, Clarithromycin?
More than you might expect — 231 in total, though they are far from equal: 13 are rated major, 180 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Vonoprazan, Amoxicillin, Clarithromycin supplement interactions are the most serious?
The 13 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Arsenic and Beer — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Vonoprazan, Amoxicillin, Clarithromycin?
Usually yes — most people on Vonoprazan, Amoxicillin, Clarithromycin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Voquezna Triple have the same supplement interactions as Vonoprazan, Amoxicillin, Clarithromycin?
Yes — Voquezna Triple all contain Vonoprazan, Amoxicillin, Clarithromycin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Vonoprazan, Amoxicillin, Clarithromycin deplete any vitamins or nutrients?
It might — Vonoprazan, Amoxicillin, Clarithromycin has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Vonoprazan, Amoxicillin, Clarithromycin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Vonoprazan, Amoxicillin, Clarithromycin and my other medications?
This page covers Vonoprazan, Amoxicillin, Clarithromycin against supplements and herbal ingredients. Checking Vonoprazan, Amoxicillin, Clarithromycin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.