Drug & supplement interaction

Lathyrus + Salmeterol

Salmeterol brand name: Serevent.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lathyrus and Salmeterol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Salmeterol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lathyrus and Salmeterol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Salmeterol and Lathyrus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lathyrus at all — not against Salmeterol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lathyrus safety at a glance

Lathyrus overall Use caution Heavy or prolonged intake of grass pea is linked to a serious nerve disorder called lathyrism.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Salmeterol and Lathyrus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Lathyrus and Salmeterol May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on reported in 15.2% of FDA reports for Salmeterol Additional detail

    Lathyrus

    “Orally, consuming a diet high in lathyrus can cause neurotoxic manifestations including muscular rigidity, spasticity, weakness, paralysis, weak pulse, shallow breathing, convulsions, or death (6,58002,58008,58009,58012,58014,58018,58021,58023,58024). Consumption of lathyrus can also result in problems with collagen crosslinking.”

    Lathyrus · Natural Medicines adverse-effect record, reported in asthma.

    6 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 58002. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. PubMed
    3. 58008. Drory, V. E., Rabey, M. J., and Cohn, D. F. Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol.Scand 1992;85(6):401-403. PubMed
    4. 58009. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. PubMed
    5. 58012. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. PubMed
    6. 58014. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. PubMed

    “When inhaled, lathyrus flour or pollen has caused allergic rhinoconjunctivitis and asthma in case reports.”

    Lathyrus · Natural Medicines adverse-effect record, reported in asthma.

    4 sources cited
    1. 58003. Porcel, S., Leon, F., Valero, A. M., Calderin, P. M., Cuevas, M., and Cuesta, E. A. Occupational rhinitis and asthma by Lathyrus sativus flour: characterization of allergens. J.Allergy Clin.Immunol. 2001;107(4):743-744. PubMed
    2. 58015. Anton, Girones M., de la Hoz, Caballer B., Munoz, Martin T., Cuevas, Agustin M., and Sanchez-Cano, M. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol.Immunopathol.(Madr.) 2005;33(6):326-328.
    3. 58019. Valdivieso, R., Quirce, S., and Sainz, T. Bronchial asthma caused by Lathyrus sativus flour. Allergy 1988;43(7):536-539.
    4. 58031. Lieberman, P. Preventing fatalities from anaphylaxis: an allergist-immunologist's perspective. Allergy Proc 1995;16(3):109-111. PubMed

    Salmeterol

    Listed in the ADVERSE REACTIONS section of the FDA label for Salmeterol, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Lathyrus but not commonly for Salmeterol: seizures.

Effects for Salmeterol come from the ADVERSE REACTIONS section of its FDA label; effects for Lathyrus come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 107,431 voluntary FDA FAERS reports for Salmeterol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Lathyrus in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Salmeterol Products Have a Food Rule — Lathyrus Should Not Break It

At least one FDA label for a product containing Salmeterol says to take it on an empty stomach. Most supplements — Lathyrus included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Salmeterol on its own and move Lathyrus to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Salmeterol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

One inhalation of SEREVENT DISKUS at least 30 minutes before exercise has been shown to protect patients against EIB.

From the Dosage and Administration section of the FDA label we read for Salmeterol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Salmeterol

This page covers Lathyrus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Salmeterol page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).

By severity: 7 major · 105 moderate · 29 minor.

From our pharmacist’s overview on the Salmeterol page

“Salmeterol (Serevent) is the long-acting inhaler taken twice daily for asthma or COPD, and its supplement list is one I would approach with real caution. Seven of the 141 ingredients on file rate major: grapefruit can raise salmeterol levels by blocking the enzyme that clears it, St.”

Reviewed by 2 · Jul 18, 2026

Open the Salmeterol interaction page

How much people look this up

Where Lathyrus and Salmeterol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lathyrus
Steady interest

#800 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Salmeterol
Steady interest

#2,546 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lathyrus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lathyrus and Salmeterol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lathyrus

What is Lathyrus?

  • Food and famine crop in some regions
  • Source of dietary protein
  • Traditional folk remedies
  • Animal fodder

Lathyrus most often refers to the grass pea (Lathyrus sativus), a hardy legume eaten as food in parts of Asia and Africa. While it is nutritious, heavy or prolonged consumption is linked to a serious neurological disorder called lathyrism, so it is not recommended as a dietary supplement. There is no good evidence supporting Lathyrus for any specific health condition.

Lathyrus sativus · Fabaceae · Seeds (grass pea / chickling pea); occasionally other plant parts · Dried seeds, flour, cooked legume dishes; not commonly sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether Lathyrus is a good idea for someone in your situation. Here is what our Lathyrus record says about it on its own.

Lathyrus: dosing

There is no established or standardized supplement dose for Lathyrus, and it is not recommended as a supplement. Because of the toxin it contains, larger and more frequent intake increases the risk of harm.If grass pea is part of your traditional diet, it is safest to eat it in moderation as one of many foods, and to prepare it by soaking and boiling. Do not rely on it as a main protein source.

From our Lathyrus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lathyrus monograph & all interactions
Medication

About Salmeterol Oral Inhalation

What Is Salmeterol Oral Inhalation Used For?

Brand name: Serevent

Serevent Diskus (salmeterol inhalation powder) is used for three main purposes: treating asthma in patients aged 4 and older alongside an inhaled corticosteroid (ICS), preventing exercise-induced bronchospasm (EIB) in patients aged 4 and older, and providing long-term maintenance treatment of bronchospasm associated with COPD — including chronic bronchitis and emphysema — in adults.

Important: Serevent Diskus is not a rescue inhaler. It will not relieve a sudden asthma or COPD attack. For asthma, it must always be used together with an inhaled corticosteroid — using it alone for asthma is contraindicated due to a serious risk of asthma-related death.

See full Salmeterol Oral Inhalation drug information
Keep checking

Other Drugs & Lathyrus

Browse every other medication we’ve checked against Lathyrus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lathyrus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lathyrus list.

See the full Lathyrus interactions page
See every supplement checked against Salmeterol, ranked by severity
Evidence & sources

Lathyrus References

The 22 references that drive our Lathyrus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. PubMed
  3. Porcel, S., Leon, F., Valero, A. M., Calderin, P. M., Cuevas, M., and Cuesta, E. A. Occupational rhinitis and asthma by Lathyrus sativus flour: characterization of allergens. J.Allergy Clin.Immunol. 2001;107(4):743-744. PubMed
  4. Drory, V. E., Rabey, M. J., and Cohn, D. F. Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol.Scand 1992;85(6):401-403. PubMed
  5. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. PubMed
  6. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. PubMed
  7. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. PubMed
  8. Anton, Girones M., de la Hoz, Caballer B., Munoz, Martin T., Cuevas, Agustin M., and Sanchez-Cano, M. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol.Immunopathol.(Madr.) 2005;33(6):326-328.
  9. Haimanot, R. T., Kidane, Y., Wuhib, E., Kalissa, A., Alemu, T., Zein, Z. A., and Spencer, P. S. Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder. Int J Epidemiol. 1990;19(3):664-672. PubMed
  10. Spencer, P. S., Roy, D. N., Ludolph, A., Hugon, J., Dwivedi, M. P., and Schaumburg, H. H. Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 11-8-1986;2(8515):1066-1067. PubMed
  11. Valdivieso, R., Quirce, S., and Sainz, T. Bronchial asthma caused by Lathyrus sativus flour. Allergy 1988;43(7):536-539.
  12. Ludolph, A. C., Hugon, J., Dwivedi, M. P., Schaumburg, H. H., and Spencer, P. S. Studies on the aetiology and pathogenesis of motor neuron diseases. 1. Lathyrism: clinical findings in established cases. Brain 1987;110 ( Pt 1):149-165. PubMed
  13. Striefler, M., Cohn, D. F., Hirano, A., and Schujman, E. The central nervous system in a case of neurolathyrism. Neurology 1977;27(12):1176-1178.
  14. Spencer, P. S. and Schaumburg, H. H. Lathyrism: a neurotoxic disease. Neurobehav.Toxicol Teratol. 1983;5(6):625-629.
  15. Cohn, D. F. and Streifler, M. Intoxication by the chickling pea (Lathyrus sativus): nervous system and skeletal findings. Arch.Toxicol.Suppl 1983;6:190-193. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lathyrus and Salmeterol Together: Common Questions

Is it safe to take Lathyrus with Salmeterol?
We do not list a known interaction between Lathyrus and Salmeterol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lathyrus and Salmeterol have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Lathyrus and Salmeterol at the same time of day?
At least one FDA label for a product containing Salmeterol says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Salmeterol on its own and move Lathyrus to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Salmeterol interact with any supplements?
Yes. Salmeterol has documented interactions with 141 supplements in our database — Lathyrus is not one of them. The Salmeterol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lathyrus monograph Uses, safety profile, and every drug interaction in one place Salmeterol Oral Inhalation drug information The full plain-English guide to this medication Salmeterol supplement interactions Every supplement checked against Salmeterol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Salmeterol and Lathyrus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.