Drug & supplement interaction

Lemon Verbena + Eszopiclone

Eszopiclone brand name: Lunesta.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lemon Verbena and Eszopiclone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Eszopiclone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Lemon Verbena and Eszopiclone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Eszopiclone and Lemon Verbena in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lemon Verbena safety at a glance

Lemon Verbena overall Use caution Generally well tolerated as a tea or food, but concentrated extracts and the essential oil are less studied.
Pregnancy Avoid Not enough safety data, so it is best avoided in medicinal amounts during pregnancy.
Breastfeeding Avoid Safety has not been established, so avoid medicinal amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Eszopiclone and Lemon Verbena? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Eszopiclone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Eszopiclone is filed under 3 classifications — cns depressants, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Lemon Verbena has documented interactions with 1 drug class — the most serious being benzodiazepines (moderate) — and none of Eszopiclone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lemon Verbena Does Interact With Other Medications

Lemon Verbena has 22 moderate known drug interactions in our database — Eszopiclone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 22 No known interaction 2,808 (incl. Eszopiclone)
Taking anything else?

Check Another of Your Medications Against Lemon Verbena

Covers the 2,830 medications we’ve checked against Lemon Verbena. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Lemon Verbena and Eszopiclone May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Lemon Verbena

    “Contact dermatitis may occur with topical application of lemon verbena (6).”

    Lemon Verbena · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

    Eszopiclone

    Listed in the ADVERSE REACTIONS section of the FDA label for Eszopiclone. Read the label on DailyMed ›

Effects for Eszopiclone come from the ADVERSE REACTIONS section of its FDA label; effects for Lemon Verbena come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Eszopiclone Products Have a Food Rule — Lemon Verbena Should Not Break It

At least one FDA label for a product containing Eszopiclone says to take it with food. If you take Lemon Verbena on an empty stomach out of habit, keep them separate — and take Eszopiclone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Eszopiclone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administration with Food Taking LUNESTA with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of LUNESTA on sleep latency [see Clinical Pharmacology ( 12.3 )] .

From the Dosage and Administration section of the FDA label we read for Eszopiclone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Eszopiclone Is Prescribed For, and What Lemon Verbena Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Eszopiclone is a prescription medicine with approved uses on its FDA label. Lemon Verbena is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Eszopiclone is prescribed for: Eszopiclone tablets — sold under the brand name Lunesta and as generics — are indicated for the treatment of insomnia. In clinical studies, eszopiclone helped people fall asleep more quickly (reduced sleep latency) and stay asleep through the night (improved sleep maintenance). Clinical trials supporting its effectiveness lasted up to 6 months in adults and up to 2 weeks in elderly patients. Lunesta and eszopiclone generics are approved for this same indication across the available tablet formulations.

Lemon Verbena has been studied for:

  • Insomnia studied, not established Lemon Verbena has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Lemon Verbena for insomnia

    Small studies suggest that oral lemon verbena leaf extract or essential oil may modestly improve some measures of sleep quality in adults with insomnia.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Eszopiclone on your own; if you are taking Lemon Verbena for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Lemon Verbena or Eszopiclone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lemon Verbena or Eszopiclone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Eszopiclone

This page covers Lemon Verbena only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Eszopiclone page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 147 moderate · 39 minor.

From our pharmacist’s overview on the Eszopiclone page

“Eszopiclone (Lunesta) is a sedative sleep medicine, so the danger that matters most here is ending up more sedated than you intended, and that danger is real on this page. Nine of the 195 interactions rate major, and I'd read those first.”

Reviewed by 2 · Jul 18, 2026

Open the Eszopiclone interaction page

One more smart check

Taking Lemon Verbena as Part of a Dietary Supplement Product? Check It for Interactions

We hold 32 real supplement products containing Lemon Verbena, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lemon Verbena. Even though Lemon Verbena itself has no known interaction with Eszopiclone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lemon Verbena and Eszopiclone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lemon Verbena
Top half

#659 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Eszopiclone
Steady interest

#2,087 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lemon Verbena reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lemon Verbena and Eszopiclone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lemon Verbena

What is Lemon Verbena?

Lemon Verbena
  • Digestive upset
  • Anxiety and trouble sleeping
  • Joint pain and inflammation
  • Exercise recovery and oxidative stress
  • Weight management
  • Flavoring and aromatherapy

Lemon verbena is a fragrant South American herb most often enjoyed as a tea or flavoring, and it contains polyphenols like verbascoside that have antioxidant activity in lab studies. Some small studies hint at benefits for inflammation, exercise recovery, and appetite, but the human evidence is limited and far from proven. It is generally well tolerated as a food and tea, but talk with your pharmacist or doctor before using concentrated supplements, and avoid it during pregnancy and breastfeeding.

Aloysia citrodora · Verbenaceae · Leaves and flowering tops; the essential oil is also used · Tea, capsules, liquid extracts, essential oil, and as a flavoring in foods and beverages

An interaction check asks whether these two react with each other — it does not ask whether Lemon Verbena is a good idea for someone in your situation. Here is what our Lemon Verbena record says about it on its own.

Lemon Verbena: dosing

There is no official or well-established standardized dose for lemon verbena. As a tea, it is commonly prepared by steeping the dried leaves in hot water, similar to other herbal teas.For capsules and extracts, products vary widely and some are standardized to a certain percentage of polyphenols or verbascoside. More is not always better, and starting with the lowest amount is a sensible approach.

From our Lemon Verbena monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lemon Verbena monograph & all interactions
Medication

About Eszopiclone

What Is Eszopiclone Used For?

Brand name: Lunesta

Eszopiclone tablets — sold under the brand name Lunesta and as generics — are indicated for the treatment of insomnia. In clinical studies, eszopiclone helped people fall asleep more quickly (reduced sleep latency) and stay asleep through the night (improved sleep maintenance).

Clinical trials supporting its effectiveness lasted up to 6 months in adults and up to 2 weeks in elderly patients. Lunesta and eszopiclone generics are approved for this same indication across the available tablet formulations.

See full Eszopiclone drug information
Keep checking

Other Drugs & Lemon Verbena

Browse every other medication we’ve checked against Lemon Verbena — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
22Moderate
0Minor
2,807No known interaction
22 Moderate 2,807 No interaction
Moderate

22 interactions

No interaction 2,807 drugs checked — show the list

We also checked Lemon Verbena against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,807 medications checked with no known interaction — see the full Lemon Verbena list.

See the full Lemon Verbena interactions page
See every supplement checked against Eszopiclone, ranked by severity
Evidence & sources

Lemon Verbena References

The 2 references that drive our Lemon Verbena monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Afrasiabian F, Mirabzadeh Ardakani M, Rahmani K, et al. Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety. Phytother Res. 2019;33(2):350-359.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lemon Verbena and Eszopiclone Together: Common Questions

Is it safe to take Lemon Verbena with Eszopiclone?
We do not list a known interaction between Lemon Verbena and Eszopiclone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lemon Verbena and Eszopiclone have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Lemon Verbena and Eszopiclone at the same time of day?
At least one FDA label for a product containing Eszopiclone says to take it with food. If you take Lemon Verbena on an empty stomach out of habit, keep them separate and take Eszopiclone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Eszopiclone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Lemon Verbena and Eszopiclone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Lemon Verbena in each. That is a conversation for your prescriber, especially if Eszopiclone is being adjusted to a target.
How was the Lemon Verbena and Eszopiclone combination checked?
Interactions in our licensed database are recorded against drug classes. Eszopiclone is filed under 3 classifications, and Lemon Verbena has documented interactions with 1 drug class — none of Eszopiclone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Lemon Verbena interact with any other medications?
Yes. Lemon Verbena has 22 documented drug interactions in our database — Eszopiclone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Eszopiclone interact with any supplements?
Yes. Eszopiclone has documented interactions with 195 supplements in our database — Lemon Verbena is not one of them. The Eszopiclone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lemon Verbena monograph Uses, safety profile, and every drug interaction in one place Eszopiclone drug information The full plain-English guide to this medication Eszopiclone supplement interactions Every supplement checked against Eszopiclone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Eszopiclone and Lemon Verbena?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.