Drug & supplement interaction

Ligandrol + Lioresal

Lioresal brand name: Lioresal Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Ligandrol and Lioresal in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ligandrol and Lioresal

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lioresal and Ligandrol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ligandrol safety at a glance

Ligandrol overall Avoid Ligandrol is an unapproved investigational drug with real safety concerns and is not a legal dietary supplement.
Pregnancy Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androge... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androge... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lioresal and Ligandrol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lioresal

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lioresal is filed under 3 classifications — baclofen, skeletal muscle relaxants, seizure threshold lowering drugs. Ligandrol has documented interactions with 1 drug class — the most serious being hepatotoxic drugs (moderate) — and none of Lioresal’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ligandrol Does Interact With Other Medications

Ligandrol has 372 moderate known drug interactions in our database — Lioresal isn’t one of them. If you take anything else, check it against the full list below.

Moderate 372 No known interaction 2,458 (incl. Lioresal)
Taking anything else?

Check Another of Your Medications Against Ligandrol

Covers the 2,830 medications we’ve checked against Ligandrol. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Ligandrol and Lioresal May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Weight loss / Itching / Stomach pain / Tiredness / Diarrhea / Nausea Additional detail

    Ligandrol

    “There are cases of liver injury thought to be related to the use of ligandrol alone or in combination with other SARMs. The U.S. Food and Drug Administration (FDA) has warned that supplements containing SARMs, such as ligandrol, have been associated with liver toxicity.

    There are at least 3 cases of liver injury thought to be related to the use of ligandrol alone.”

    Ligandrol · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 94879. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
    2. 94880. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
    3. 94881. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
    4. 112650. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
    5. 112682. Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
    6. 112683. Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed

    Lioresal

    Listed in the ADVERSE REACTIONS section of the FDA label for Lioresal. Read the label on DailyMed ›

Reported for Ligandrol but not commonly for Lioresal: liver problems and yellowing of the skin or eyes.

Effects for Lioresal come from the ADVERSE REACTIONS section of its FDA label; effects for Ligandrol come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Ligandrol in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen receptor modulators (SARMs) are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Ligandrol or Lioresal

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ligandrol or Lioresal, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lioresal

This page covers Ligandrol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lioresal page lists 10 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Procaine (major), Biofeedback (moderate), Dendrobium (moderate), Ginkgo (moderate) and Lithium (moderate).

By severity: 1 major · 9 moderate.

From our pharmacist’s overview on the Lioresal page

“Lioresal is baclofen, a muscle relaxant prescribed for spasticity, and I would treat its supplement list with genuine care. Of the ten ingredients on file, six, including everyday picks like melatonin and ginkgo, may lower the seizure threshold, an added worry with a drug whose abrupt changes can already provoke seizures.”

Reviewed by 2 · Jul 18, 2026

Open the Lioresal interaction page

One more smart check

Taking Ligandrol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 26 real supplement products containing Ligandrol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ligandrol. Even though Ligandrol itself has no known interaction with Lioresal, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ligandrol and Lioresal Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ligandrol
Steady interest

#829 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lioresal
Top half

#920 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ligandrol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Ligandrol and Lioresal records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ligandrol

What is Ligandrol?

  • Muscle building
  • Athletic performance and strength
  • Body recomposition
  • Bodybuilding cycles

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approved for human use, is banned in sports, and has been linked to liver injury and hormonal disruption, so it should not be taken as a supplement.

Not applicable (synthetic compound) · Capsules, tablets, liquid (research chemical), powder

An interaction check asks whether these two react with each other — it does not ask whether Ligandrol is a good idea for someone in your situation. Here is what our Ligandrol record says about it on its own.

Ligandrol: dosing

There is no established or approved safe dose of Ligandrol because it is not an approved medicine or legal supplement. Doses used in early research and in bodybuilding are not verified for safety, and product labels cannot be trusted to be accurate.Because of the real risks and the lack of an approved dose, the safest choice is not to take it at all.

From our Ligandrol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ligandrol monograph & all interactions
Medication

About Baclofen

What Is Baclofen Used For?

Brand name: Lioresal Injection

Baclofen treats spasticity, which means stiff, tight muscles with spasms. Oral baclofen (tablets, Baclofen oral solution, Ozobax, Baclofen oral suspension, Fleqsuvy, Lyvispah) is used for spasticity from multiple sclerosis, especially flexor spasms with pain, clonus (rhythmic jerking) and muscle rigidity. It may also help some people with spinal cord injuries and other spinal cord diseases.

Intrathecal baclofen (Gablofen, Lioresal Intrathecal and other baclofen injections) is used for severe spasticity. It is given into the fluid around the spinal cord, usually through an implanted pump. It is not for skeletal muscle spasm from rheumatic disorders, and baclofen tablets are not recommended for stroke, cerebral palsy or Parkinson’s disease.

See full Baclofen drug information
Keep checking

Other Drugs & Ligandrol

Browse every other medication we’ve checked against Ligandrol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
372Moderate
0Minor
2,457No known interaction
372 Moderate 2,457 No interaction
Moderate

372 interactions

Showing 60 of 372 moderate interactions — see all 372 on the Ligandrol page.

No interaction 2,457 drugs checked — show the list

We also checked Ligandrol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,457 medications checked with no known interaction — see the full Ligandrol list.

See the full Ligandrol interactions page
See every supplement checked against Lioresal, ranked by severity
Evidence & sources

Ligandrol References

The 9 references that drive our Ligandrol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  3. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  4. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  5. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
  6. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
  7. Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
  8. Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed
  9. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2013;68(1):87-95. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ligandrol and Lioresal Together: Common Questions

Is it safe to take Ligandrol with Lioresal?
We do not list a known interaction between Ligandrol and Lioresal. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ligandrol and Lioresal have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Ligandrol and Lioresal combination checked?
Interactions in our licensed database are recorded against drug classes. Lioresal is filed under 3 classifications, and Ligandrol has documented interactions with 1 drug class — none of Lioresal's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ligandrol interact with any other medications?
Yes. Ligandrol has 372 documented drug interactions in our database — Lioresal is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lioresal interact with any supplements?
Yes. Lioresal has documented interactions with 10 supplements in our database — Ligandrol is not one of them. The Lioresal interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ligandrol monograph Uses, safety profile, and every drug interaction in one place Baclofen drug information The full plain-English guide to this medication Lioresal supplement interactions Every supplement checked against Lioresal, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lioresal and Ligandrol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.