Drug & supplement interaction

Mace + Ketoprofen

Ketoprofen brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Mace and Ketoprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ketoprofen states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mace and Ketoprofen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ketoprofen and Mace in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mace safety at a glance

Mace overall Use caution Safe as a culinary spice but large or concentrated doses can be toxic.
Pregnancy Possibly Unsafe When used orally in medicinal amounts. Mace might have abortifacient activity, and its safrole content might be mutagenic. Read the full pregnancy detail
Breastfeeding Use caution Food amounts are probably fine, but avoid concentrated supplements due to lack of safety data.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ketoprofen and Mace? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ketoprofen

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ketoprofen is filed under 8 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), anticoagulant/antiplatelet drugs, organic anion transporter 3 (oat3) substrates. Mace has documented interactions with 4 drug classes — the most serious being cns depressants (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and immunosuppressants (moderate) — and none of Ketoprofen’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Mace Does Interact With Other Medications

Mace has 500 moderate known drug interactions in our database — Ketoprofen isn’t one of them. If you take anything else, check it against the full list below.

Moderate 500 No known interaction 2,330 (incl. Ketoprofen)
Taking anything else?

Check Another of Your Medications Against Mace

Covers the 2,830 medications we’ve checked against Mace. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Mace and Ketoprofen May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations / Confusion Worth acting on Additional detail

    Mace

    “There are no reports of adverse psychiatric events due to ingestion of mace. However, mace contains myristicin, which is structurally similar to certain hallucinogenic chemicals. High intake of nutmeg, a similar herb, has been reported to cause mild to intense visual hallucinations, auditory hallucinations, feelings of impending doom, euphoria, anxiety, disorientation, stupor, agitation, insomnia, and restlessness (1…”

    Mace · Natural Medicines adverse-effect record, reported in anxiety.

    5 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 2563. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
    3. 19300. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
    4. 19489. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
    5. 19492. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Mace

    “There are no reports of adverse cardiovascular events due to ingestion of mace. However, mace contains myristicin, which is structurally similar to certain hallucinogenic chemicals. High intake of nutmeg, a related herb, has been associated with non-specific electrocardiographic changes, tachycardia, palpitations, weak pulse, hypotension, chest pain, and flushing (12,19293,19300,25547,25943).”

    Mace · Natural Medicines adverse-effect record, reported in hypotension.

    5 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 19293. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
    3. 19300. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
    4. 25547. Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. PubMed
    5. 25943. Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. PubMed

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

  • Drowsiness / Headache / Dizziness reported in 9.4% of FDA reports for Ketoprofen Additional detail

    Mace

    “There are no reports of adverse neurologic or central nervous system (CNS)-related events due to ingestion of mace. However, mace contains myristicin, which is structurally similar to certain hallucinogenic chemicals. High intake of nutmeg, a similar herb, has been reported to cause headache, dizziness, drowsiness, hot and cold sensations, sensations of limb loss, convulsions, and coma.”

    Mace · Natural Medicines adverse-effect record, reported in cluster headache.

    4 sources cited
    1. 2563. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
    2. 19294. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
    3. 19300. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
    4. 19487. Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Anxiety or restlessness / Trouble sleeping Additional detail

    Mace

    Recorded for Mace in the same Natural Medicines adverse-effect record shown under Hallucinations / Confusion above.

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

  • Nausea reported in 6.1% of FDA reports for Ketoprofen Additional detail

    Mace

    “There are no reports of adverse gastrointestinal events due to ingestion of mace. However, mace contains myristicin, which is structurally similar to certain hallucinogenic chemicals. High intake of nutmeg, a similar spice, has been reported to cause nausea and vomiting, epigastric pain, and gastroenteritis. Theoretically, high intake of mace may have similar effects.”

    Mace · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 2563. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
    2. 19294. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
    3. 19300. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Mace

    “Orally, mace seems to be well tolerated when consumed in appropriate amounts. No adverse effects have been reported, although a thorough evaluation of safety outcomes has not been conducted. However, severe cardiovascular, gastrointestinal, neurologic, ocular, and psychiatric adverse events have been reported following high intake of the related herb nutmeg.”

    Mace · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 19293. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
    2. 19492. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
    3. 39898. Dooms-Goossens, A., Dubelloy, R., and Degreef, H. Contact and systemic contact-type dermatitis to spices. Dermatol Clin 1990;8(1):89-93. DOI

    “Topically, contact and systemic contact-type dermatitis to mace has occurred in rare cases.”

    Mace · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 39898. Dooms-Goossens, A., Dubelloy, R., and Degreef, H. Contact and systemic contact-type dermatitis to spices. Dermatol Clin 1990;8(1):89-93. DOI

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

Showing the 10 most notable of 11 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Mace but not commonly for Ketoprofen: seizures, low blood pressure, chest pain and flushing.

Effects for Ketoprofen come from the ADVERSE REACTIONS section of its FDA label; effects for Mace come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 13,040 voluntary FDA FAERS reports for Ketoprofen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Mace in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally in medicinal amounts. Mace might have abortifacient activity, and its safrole content might be mutagenic.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Ketoprofen Products Have a Food Rule — Mace Should Not Break It

At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Mace on an empty stomach out of habit, keep them separate — and take Ketoprofen with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ketoprofen products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Although food delays the absorption of both formulations (see CLINICAL PHARMACOLOGY ) in most of the clinical trials ketoprofen was taken with food or milk.

From the Dosage and Administration section of the FDA label we read for Ketoprofen — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Ketoprofen Is Prescribed For, and What Mace Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Ketoprofen is a prescription medicine with approved uses on its FDA label. Mace is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Ketoprofen is prescribed for: Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods). Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.

Mace has been studied for:

  • Dysmenorrhea studied, not established Mace has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Mace for dysmenorrhea

    In patients with dysmenorrhea, preliminary clinical research shows that taking a palm sap-sweetened herbal decoction 180 mL made with a combination of mace 3 grams and Cassia fistula 21 grams for 3 days starting just before expected menstruation and repeating for two menstrual cycles reduces pain by a large amount and the duration of pain by a small amount when compared with the same three days of the menstrual cycle…

    1 source cited
    1. 103376. Anjum A, Sultana A. A randomized comparative study of herbal decoction of Cassia fistula Linn pod's pericarp and Myristica fragrans Houtt arils vs. mefenamic acid in spasmodic dysmenorrhoea. J Complement Integr Med. 2018;16(2):/j/jcim.2019.16.issue-2/jcim

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ketoprofen on your own; if you are taking Mace for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Ketoprofen

This page covers Mace only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ketoprofen page lists 252 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 217 moderate · 28 minor.

From our pharmacist’s overview on the Ketoprofen page

“Bleeding is what worries me most with ketoprofen (Orudis, Oruvail Gel). As an NSAID, it already irritates the stomach lining and slows clotting, and 202 of the 252 supplements and herbs on this page can push that bleeding risk further.”

Reviewed by 2 · Jul 18, 2026

Open the Ketoprofen interaction page

One more smart check

Taking Mace as Part of a Dietary Supplement Product? Check It for Interactions

We hold 38 real supplement products containing Mace, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mace. Even though Mace itself has no known interaction with Ketoprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mace and Ketoprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mace
Steady interest

#803 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ketoprofen
Top half

#1,183 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mace reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Mace and Ketoprofen records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mace

What is Mace?

  • Digestive upset and gas
  • Flavoring and culinary spice
  • Nausea
  • Appetite stimulation
  • Traditional pain or muscle relief

Mace is the lacy red covering of the nutmeg seed and comes from the same tree as nutmeg. It is mostly used as a cooking spice and in traditional medicine for digestion, but there is little solid human research to support its health uses. In normal food amounts it is generally safe, but large doses can be toxic, so use it as a spice and check with your pharmacist before taking concentrated supplements.

Myristica fragrans · Myristicaceae · The dried red, lacy covering (aril) of the nutmeg seed · Whole dried blades, ground powder, essential oil, capsules

An interaction check asks whether these two react with each other — it does not ask whether Mace is a good idea for someone in your situation. Here is what our Mace record says about it on its own.

Mace: dosing

There is no established standardized medicinal dose for mace. As a spice, the amount used in cooking is small and considered safe.If you choose to use a mace supplement, follow the directions on the product label and do not exceed them. Because high amounts can be toxic, more is not better.

From our Mace monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mace monograph & all interactions
Medication

About Ketoprofen

What Is Ketoprofen Used For?

Brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection

Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods).

Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.

Most-Reported Side Effects for Ketoprofen

From FAERS, the FDA’s public side-effect reporting system (13,040 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 1,232 reports
Fatigue 932 reports
Nausea 799 reports
Infusion site pain 764 reports
Fever 756 reports
See full Ketoprofen drug information
Keep checking

Other Drugs & Mace

Browse every other medication we’ve checked against Mace — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
500Moderate
0Minor
2,329No known interaction
500 Moderate 2,329 No interaction
Moderate

500 interactions

Showing 60 of 500 moderate interactions — see all 500 on the Mace page.

No interaction 2,329 drugs checked — show the list

We also checked Mace against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,329 medications checked with no known interaction — see the full Mace list.

See the full Mace interactions page
See every supplement checked against Ketoprofen, ranked by severity
Evidence & sources

Mace References

The 18 references that drive our Mace monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
  3. Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. DOI
  4. Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. PubMed
  5. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
  6. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
  7. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
  8. Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed
  9. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
  10. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
  11. Checker R, Chatterjee S, Sharma D, et al. Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol. 2008;8(5):661-669. PubMed
  12. Sell AB, Carlini EA. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology. 1976;14(4):367-77. PubMed
  13. Fundarò A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375-80.
  14. Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. PubMed
  15. Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mace and Ketoprofen Together: Common Questions

Is it safe to take Mace with Ketoprofen?
We do not list a known interaction between Mace and Ketoprofen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mace and Ketoprofen have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Mace and Ketoprofen at the same time of day?
At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Mace on an empty stomach out of habit, keep them separate and take Ketoprofen with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ketoprofen products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Mace and Ketoprofen used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Mace in each. That is a conversation for your prescriber, especially if Ketoprofen is being adjusted to a target.
How was the Mace and Ketoprofen combination checked?
Interactions in our licensed database are recorded against drug classes. Ketoprofen is filed under 8 classifications, and Mace has documented interactions with 4 drug classes — none of Ketoprofen's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Mace interact with any other medications?
Yes. Mace has 500 documented drug interactions in our database — Ketoprofen is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ketoprofen interact with any supplements?
Yes. Ketoprofen has documented interactions with 252 supplements in our database — Mace is not one of them. The Ketoprofen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mace monograph Uses, safety profile, and every drug interaction in one place Ketoprofen drug information The full plain-English guide to this medication Ketoprofen supplement interactions Every supplement checked against Ketoprofen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ketoprofen and Mace?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.