Drug & supplement interaction

Maral Root + Canagliflozin, Metformin

Canagliflozin, Metformin brand name: Invokamet.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Maral Root and Canagliflozin, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Canagliflozin, Metformin states a food rule worth keeping to.

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Interaction report

Maral Root and Canagliflozin, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Canagliflozin, Metformin and Maral Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Maral Root safety at a glance

Maral Root overall Use caution Limited human safety data, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Canagliflozin, Metformin and Maral Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Canagliflozin, Metformin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Canagliflozin, Metformin is filed under 4 classifications — including organic cation transporter 2 (oct2) substrates, antidiabetes drugs, oral drugs. Maral Root has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Canagliflozin, Metformin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Maral Root Does Interact With Other Medications

Maral Root has 122 moderate known drug interactions in our database — Canagliflozin, Metformin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Canagliflozin, Metformin)
Taking anything else?

Check Another of Your Medications Against Maral Root

Covers the 2,830 medications we’ve checked against Maral Root. Pick one to open its full report.

What to actually watch for

What Canagliflozin, Metformin’s Own FDA Label Lists

This is not an interaction — none of it involves Maral Root. These are the most notable effects listed in the ADVERSE REACTIONS section of Canagliflozin, Metformin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Bone thinning Worth acting on
  • Dehydration Worth acting on
  • High potassium Worth acting on
  • Low blood sugar Worth acting on
  • Pancreatitis Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on
  • Fainting Worth acting on
  • Seizures Worth acting on
  • Kidney problems Worth acting on

Showing the 10 most notable of 32 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Canagliflozin, Metformin. Read the label on DailyMed › Maral Root’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Maral Root side to compare — that is a limit of the record, not a statement that Maral Root has no side effects.

How to take them

Some Canagliflozin, Metformin Products Have a Food Rule — Maral Root Should Not Break It

At least one FDA label for a product containing Canagliflozin, Metformin says to take it with food. If you take Maral Root on an empty stomach out of habit, keep them separate — and take Canagliflozin, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Canagliflozin, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

INVOKAMET: take one tablet orally twice daily with meals ( 2.2 ).

From the Dosage and Administration section of the FDA label we read for Canagliflozin, Metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Canagliflozin, Metformin

This page covers Maral Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Canagliflozin, Metformin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Canagliflozin, Metformin page

“Invokamet combines canagliflozin and metformin, two medicines that lower blood sugar by different routes, so nearly everything here, 239 of the 257 ingredients on file, touches glucose control in one direction or the other. Most add their own sugar-lowering effect and can stack with the drug to drop blood sugar too far, while a few pus…”

Reviewed by 2 · Jul 18, 2026

Open the Canagliflozin, Metformin interaction page

One more smart check

Taking Maral Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 82 real supplement products containing Maral Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maral Root. Even though Maral Root itself has no known interaction with Canagliflozin, Metformin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maral Root and Canagliflozin, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maral Root
Top half

#522 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Canagliflozin, Metformin
Steady interest

#1,877 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maral Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Maral Root and Canagliflozin, Metformin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Maral Root

What is Maral Root?

  • Physical performance and stamina
  • Muscle building
  • Fatigue and recovery
  • Stress and adaptation
  • General energy and vitality

Maral Root (Rhaponticum carthamoides) is a Siberian herb used as an 'adaptogen' and is popular among athletes for stamina and muscle building, largely because it contains plant compounds called ecdysteroids. Human evidence is very limited, so its benefits remain mostly unproven. Talk with a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.

Rhaponticum carthamoides · Asteraceae · Root and rhizome · Capsules, tablets, powder, liquid extract/tincture, tea

An interaction check asks whether these two react with each other — it does not ask whether Maral Root is a good idea for someone in your situation. Here is what our Maral Root record says about it on its own.

Maral Root: dosing

There is no officially established standard dose for Maral Root. Products vary widely in their strength and how much active compound they contain.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Maral Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Maral Root monograph & all interactions
Keep checking

Other Drugs & Maral Root

Browse every other medication we’ve checked against Maral Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Maral Root page.

No interaction 2,707 drugs checked — show the list

We also checked Maral Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Maral Root list.

See the full Maral Root interactions page
See every supplement checked against Canagliflozin, Metformin, ranked by severity
Evidence & sources

Maral Root References

The 2 references that drive our Maral Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Koleckar V, Brojerova E, Rehakova Z, et al. In vitro antiplatelet activity of flavonoids from Leuzea carthamoides. Drug Chem Toxicol 2008;31(1):27-35.
  2. Ryan ED, Gerstner GR, Mota JA, et al. The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial. J Diet Suppl 2021;18(5):507-516. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Maral Root and Canagliflozin, Metformin Together: Common Questions

Is it safe to take Maral Root with Canagliflozin, Metformin?
We do not list a known interaction between Maral Root and Canagliflozin, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Maral Root and Canagliflozin, Metformin at the same time of day?
At least one FDA label for a product containing Canagliflozin, Metformin says to take it with food. If you take Maral Root on an empty stomach out of habit, keep them separate and take Canagliflozin, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Canagliflozin, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Maral Root and Canagliflozin, Metformin combination checked?
Interactions in our licensed database are recorded against drug classes. Canagliflozin, Metformin is filed under 4 classifications, and Maral Root has documented interactions with 1 drug class — none of Canagliflozin, Metformin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Maral Root interact with any other medications?
Yes. Maral Root has 122 documented drug interactions in our database — Canagliflozin, Metformin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Canagliflozin, Metformin interact with any supplements?
Yes. Canagliflozin, Metformin has documented interactions with 257 supplements in our database — Maral Root is not one of them. The Canagliflozin, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Maral Root monograph Uses, safety profile, and every drug interaction in one place Canagliflozin, Metformin supplement interactions Every supplement checked against Canagliflozin, Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Canagliflozin, Metformin and Maral Root?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.