Drug & supplement interaction

Mastic + Cabotegravir, Rilpivirine

Cabotegravir, Rilpivirine brand name: Cabenuva.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Mastic and Cabotegravir, Rilpivirine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Mastic and Cabotegravir, Rilpivirine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cabotegravir, Rilpivirine and Mastic in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Mastic at all — not against Cabotegravir, Rilpivirine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mastic safety at a glance

Mastic overall Use caution Generally well tolerated in food and traditional amounts, but supplement-strength data are limited.
Pregnancy Avoid Not enough safety information; best to avoid medicinal amounts during pregnancy.
Breastfeeding Avoid Not enough safety information; best to avoid medicinal amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cabotegravir, Rilpivirine and Mastic? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Mastic Itself Has Been Linked To

This is not an interaction — nothing below involves Cabotegravir, Rilpivirine. It is the side-effect record for Mastic on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Mastic, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on Additional detail

    “Subcutaneously, administration of a specific mastic extract (RPh201, Regenera Pharma) has been most commonly reported to cause injection site pain and erythema. Pruritus, rash, and ecchymosis have also been reported with this extract.

    Topically, use of a specific mastic gum- and storax gum-containing product (Mastisol Liquid Adhesive, Ferndale Laboratories) has been associated with cases of allergic contact dermatiti…”

    Mastic · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 103266. Hazan Z, Adamsky K, Lucassen A, Levin LA. A first-in-human phase 1 randomized single and multiple ascending dose study of RPh201 in healthy volunteers. Clin Pharmacol Drug Dev. 2020;9(3):366-74. PubMed
    2. 106467. Moraschini V, Kischinhevsky ICC, Calasans-Maia MD, et al. Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clin Oral Investig 2020;24(6):1877-1888. PubMed
  • Constipation / Diarrhea / Nausea Additional detail

    “Orally, nausea, diarrhea, and constipation have been rarely reported following use of mastic gum. In one case, constipation ceased two days after discontinuing mastic gum.”

    Mastic · Natural Medicines adverse-effect record, reported in constipation.

    3 sources cited
    1. 62051. Kaliora, A. C., Stathopoulou, M. G., Triantafillidis, J. K., Dedoussis, G. V., and Andrikopoulos, N. K. Chios mastic treatment of patients with active Crohn's disease. World J Gastroenterol. 2-7-2007;13(5):748-753. PubMed
    2. 62069. Dabos, K. J., Sfika, E., Vlatta, L. J., and Giannikopoulos, G. The effect of mastic gum on Helicobacter pylori: a randomized pilot study. Phytomedicine. 2010;17(3-4):296-299. PubMed
    3. 62071. Dabos, K. J., Sfika, E., Vlatta, L. J., Frantzi, D., Amygdalos, G. I., and Giannikopoulos, G. Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial. J Ethnopharmacol. 2-3-20 PubMed
  • Itching Additional detail

    Recorded for Mastic in the same Natural Medicines adverse-effect record shown under Bleeding or bruising above.

  • Dizziness / Headache Additional detail

    “Subcutaneously, administration of a specific mastic extract (RPh201, Regenera Pharma) has been reported to cause headache and dizziness.”

    Mastic · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 103266. Hazan Z, Adamsky K, Lucassen A, Levin LA. A first-in-human phase 1 randomized single and multiple ascending dose study of RPh201 in healthy volunteers. Clin Pharmacol Drug Dev. 2020;9(3):366-74. PubMed
  • A skin rash Additional detail

    Recorded for Mastic in the same Natural Medicines adverse-effect record shown under Dizziness / Headache above.

Everything above comes from the Natural Medicines adverse-effect record for Mastic — expand a row for the licensed statement it rests on. We haven’t matched Cabotegravir, Rilpivirine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Cabotegravir, Rilpivirine.

Overlapping uses

What Cabotegravir, Rilpivirine Is Prescribed For, and What Mastic Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Cabotegravir, Rilpivirine is a prescription medicine with approved uses on its FDA label. Mastic is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Cabotegravir, Rilpivirine is prescribed for: CABENUVA (cabotegravir + rilpivirine) is used to treat HIV-1 infection in adults and adolescents 12 years and older who weigh at least 35 kg (about 77 lbs). It is not a starter treatment — it's designed for people who are already virologically suppressed, meaning their HIV is currently undetectable on a stable daily pill regimen and who have no history of treatment failure. The goal is to keep the virus fully suppressed while freeing the person from taking a pill every day. Because it stays active in the body for weeks after each injection, strict adherence to the injection schedule is essential.

Mastic has been studied for:

  • Cancer studied, not established Mastic has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Mastic for cancer

    Although there has been interest in using oral mastic for cancer, there is insufficient reliable information about the clinical effects of mastic for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Cabotegravir, Rilpivirine on your own; if you are taking Mastic for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Cabotegravir, Rilpivirine

This page covers Mastic only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cabotegravir, Rilpivirine page lists 134 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).

By severity: 7 major · 98 moderate · 29 minor.

From our pharmacist’s overview on the Cabotegravir, Rilpivirine page

“Cabenuva, the long-acting injection of cabotegravir and rilpivirine given every month or two, keeps HIV suppressed only while its blood levels hold steady, so the 134 supplement interactions on file here deserve real vigilance. St.”

Reviewed by 2 · Jul 18, 2026

Open the Cabotegravir, Rilpivirine interaction page

One more smart check

Taking Mastic as Part of a Dietary Supplement Product? Check It for Interactions

We hold 104 real supplement products containing Mastic, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mastic. Even though Mastic itself has no known interaction with Cabotegravir, Rilpivirine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mastic and Cabotegravir, Rilpivirine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mastic
Top half

#513 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cabotegravir, Rilpivirine
Top 25%

#294 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mastic reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mastic and Cabotegravir, Rilpivirine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mastic

What is Mastic?

Mastic
  • Indigestion and stomach upset
  • Stomach ulcers and H. pylori support
  • Oral and gum health
  • Bad breath
  • General antioxidant/anti-inflammatory support

Mastic is a resin from the mastic tree that has a long history of use for digestive complaints and oral health. Some small studies suggest it may help with indigestion, stomach ulcers, and dental hygiene, but the evidence is limited and not conclusive. It is generally well tolerated in food amounts, but talk to your pharmacist or doctor before using it as a supplement, especially if you are pregnant or breastfeeding.

Pistacia lentiscus · Anacardiaceae · Resin (gum) from the tree; sometimes the essential oil · Capsules, chewable gum/resin tears, powder, essential oil, mouthwash, toothpaste

An interaction check asks whether these two react with each other — it does not ask whether Mastic is a good idea for someone in your situation. Here is what our Mastic record says about it on its own.

Mastic: dosing

There is no official or standardized dose of mastic. Studies have used different forms and amounts, so it is hard to recommend one exact dose. The strength of capsules, powders, and chewing products can vary a lot between brands.The safest approach is to follow the directions on the product label and not exceed the suggested amount. Because supplements are not tightly regulated, choose a reputable brand when possible.

From our Mastic monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mastic monograph & all interactions
Medication

About Cabotegravir and Rilpivirine Injections

What Is Cabotegravir and Rilpivirine Injections Used For?

Brand name: Cabenuva

CABENUVA (cabotegravir + rilpivirine) is used to treat HIV-1 infection in adults and adolescents 12 years and older who weigh at least 35 kg (about 77 lbs). It is not a starter treatment — it's designed for people who are already virologically suppressed, meaning their HIV is currently undetectable on a stable daily pill regimen and who have no history of treatment failure.

The goal is to keep the virus fully suppressed while freeing the person from taking a pill every day. Because it stays active in the body for weeks after each injection, strict adherence to the injection schedule is essential.

See full Cabotegravir and Rilpivirine Injections drug information
Keep checking

Other Drugs & Mastic

Browse every other medication we’ve checked against Mastic — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mastic against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mastic list.

See the full Mastic interactions page
See every supplement checked against Cabotegravir, Rilpivirine, ranked by severity
Evidence & sources

Mastic References

The 5 references that drive our Mastic monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kaliora, A. C., Stathopoulou, M. G., Triantafillidis, J. K., Dedoussis, G. V., and Andrikopoulos, N. K. Chios mastic treatment of patients with active Crohn's disease. World J Gastroenterol. 2-7-2007;13(5):748-753. PubMed
  2. Dabos, K. J., Sfika, E., Vlatta, L. J., and Giannikopoulos, G. The effect of mastic gum on Helicobacter pylori: a randomized pilot study. Phytomedicine. 2010;17(3-4):296-299. PubMed
  3. Dabos, K. J., Sfika, E., Vlatta, L. J., Frantzi, D., Amygdalos, G. I., and Giannikopoulos, G. Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial. J Ethnopharmacol. 2-3-20 PubMed
  4. Hazan Z, Adamsky K, Lucassen A, Levin LA. A first-in-human phase 1 randomized single and multiple ascending dose study of RPh201 in healthy volunteers. Clin Pharmacol Drug Dev. 2020;9(3):366-74. PubMed
  5. Moraschini V, Kischinhevsky ICC, Calasans-Maia MD, et al. Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clin Oral Investig 2020;24(6):1877-1888. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mastic and Cabotegravir, Rilpivirine Together: Common Questions

Is it safe to take Mastic with Cabotegravir, Rilpivirine?
We do not list a known interaction between Mastic and Cabotegravir, Rilpivirine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Mastic and Cabotegravir, Rilpivirine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Mastic in each. That is a conversation for your prescriber, especially if Cabotegravir, Rilpivirine is being adjusted to a target.
Does Cabotegravir, Rilpivirine interact with any supplements?
Yes. Cabotegravir, Rilpivirine has documented interactions with 134 supplements in our database — Mastic is not one of them. The Cabotegravir, Rilpivirine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mastic monograph Uses, safety profile, and every drug interaction in one place Cabotegravir and Rilpivirine Injections drug information The full plain-English guide to this medication Cabotegravir, Rilpivirine supplement interactions Every supplement checked against Cabotegravir, Rilpivirine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cabotegravir, Rilpivirine and Mastic?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.