Medication interaction hub

What Supplements Interact with Cabotegravir, Rilpivirine?

Cabotegravir, Rilpivirine brand name: Cabenuva. Every interaction below applies to the brands too.

134 Interactions 7 Major 98 Moderate 29 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cabotegravir, Rilpivirine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cabotegravir, Rilpivirine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Cabenuva, the long-acting injection of cabotegravir and rilpivirine given every month or two, keeps HIV suppressed only while its blood levels hold steady, so the 134 supplement interactions on file here deserve real vigilance. St. John's wort is the one to know first, since human studies show it lowers levels of drugs in rilpivirine's class enough to risk treatment failure and viral resistance. Grapefruit does the opposite, raising levels of drugs handled by the CYP3A4 enzyme.

Seven entries rate major. Beyond those two, the others are herbs such as ephedra that can prolong the QT interval, a heart rhythm effect rilpivirine can also produce, so the risks stack. The 98 moderate and 29 minor entries mostly shift levels through that same CYP3A4 pathway, with a dozen foods (cabbage among them) speeding elimination of glucuronidated drugs. Levels that quietly drift too low can cost you the treatment itself.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 98 Minor 29 No known interaction 1,318

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Cabotegravir, Rilpivirine: Top Interactions at a Glance

The Cabotegravir, Rilpivirine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 134 interacting ingredients — plus 1,318 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Cabotegravir, Rilpivirine Combinations Today

The Cabotegravir, Rilpivirine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Milk Thistle + Cabotegravir, Rilpivirinei

Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Read the full interaction Moderate Likelihood Possible Ginger + Cabotegravir, Rilpivirinei

Ginger might increase or decrease the levels of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Cabotegravir, Rilpivirinei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Goldenseal + Cabotegravir, Rilpivirinei

Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Probable Schisandra + Cabotegravir, Rilpivirinei

Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible K2/spice + Cabotegravir, Rilpivirinei

Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmias.

Read the full interaction
The complete list

Every Supplement Checked Against Cabotegravir, Rilpivirine

All 1,452 ingredients in our database, ranked by severity — 134 with a Cabotegravir, Rilpivirine interaction on file and 1,318 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cabotegravir, Rilpivirine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Milk Thistle with Cabotegravir, Rilpivirine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Full Milk Thistle + Cabotegravir, Rilpivirine answer

Can you take Ginger with Cabotegravir, Rilpivirine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Cabotegravir, Rilpivirine answer

Can you take Grapefruit with Cabotegravir, Rilpivirine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Cabotegravir, Rilpivirine answer

Can you take Goldenseal with Cabotegravir, Rilpivirine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Cabotegravir, Rilpivirine answer

Can you take Schisandra with Cabotegravir, Rilpivirine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Cabotegravir, Rilpivirine answer

Can you take Fucus Vesiculosus with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Cabotegravir, Rilpivirine answer

Can you take Hemp with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.

Full Hemp + Cabotegravir, Rilpivirine answer

Can you take Hibiscus Sabdariffa with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Cabotegravir, Rilpivirine answer

Can you take Honey with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Full Honey + Cabotegravir, Rilpivirine answer

Can you take Hops with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Cabotegravir, Rilpivirine answer

Can you take Melatonin with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.

Full Melatonin + Cabotegravir, Rilpivirine answer

Can you take Passion Flower with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Cabotegravir, Rilpivirine answer

Can you take Rhodiola with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Full Rhodiola + Cabotegravir, Rilpivirine answer

Can you take Vitamin D with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Cabotegravir, Rilpivirine answer

Can you take Yerba Mate with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.

Full Yerba Mate + Cabotegravir, Rilpivirine answer

Can you take Yohimbe with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Cabotegravir, Rilpivirine answer

Can you take Chrysin with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.

Full Chrysin + Cabotegravir, Rilpivirine answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.

Full Delta-9-tetrahydrocannabinol (thc) + Cabotegravir, Rilpivirine answer

Can you take Eleuthero with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Cabotegravir, Rilpivirine answer

Can you take Green Tea with Cabotegravir, Rilpivirine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Cabotegravir, Rilpivirine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cabotegravir, Rilpivirine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cabotegravir, Rilpivirine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cabotegravir, Rilpivirine sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Cabotegravir, Rilpivirine through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Cabotegravir, Rilpivirine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Cabotegravir, Rilpivirine through this category.

Non-Nucleoside Reverse Transcriptase Inhibitors (Nnrtis) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Cabotegravir, Rilpivirine through this category.

About Cabotegravir, Rilpivirine

CABENUVA is a long-acting injectable HIV-1 treatment given once a month or every two months — replacing daily pills for adults and teens already controlling their virus.

Generic name: Cabotegravir, Rilpivirine  ·  Brand name: Cabenuva.

See the full Cabotegravir and Rilpivirine Injections drug information
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Take a Supplement Product? Check the Whole Bottle Against Cabotegravir, Rilpivirine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cabotegravir, Rilpivirine.

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Pharmacist Counseling Corner

Cabotegravir, Rilpivirine & Supplements: Common Questions

What supplements interact with Cabotegravir, Rilpivirine?
In our interaction database, 134 supplement and herbal ingredients have an interaction with Cabotegravir, Rilpivirine on file — 7 rated major, 98 moderate, and 29 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, St. John's Wort, Arsenic.
Which Cabotegravir, Rilpivirine supplement interactions are the most serious?
The 7 major-rated combinations — led by Grapefruit, St. John's Wort, Arsenic, Cesium and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Cabotegravir, Rilpivirine?
That depends entirely on which supplement. The honest answer for Cabotegravir, Rilpivirine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Cabenuva have the same supplement interactions as Cabotegravir, Rilpivirine?
Yes — Cabenuva all contain Cabotegravir, Rilpivirine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Cabotegravir, Rilpivirine and my other medications?
This page covers Cabotegravir, Rilpivirine against supplements and herbal ingredients. Checking Cabotegravir, Rilpivirine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Cabotegravir and Rilpivirine Injections drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.