Drug & supplement interaction

Niacinamide + Aripiprazole Lauroxil

Aripiprazole Lauroxil brand names: Aristada, Aristada Initio Kit.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Niacinamide and Aripiprazole Lauroxil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Niacinamide and Aripiprazole Lauroxil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Aripiprazole Lauroxil and Niacinamide in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Niacinamide safety at a glance

Niacinamide overall Use caution Usually well tolerated at recommended amounts, but high doses can cause side effects and should be supervised.
Pregnancy Likely Safe When used orally in amounts that do not exceed the tolerable upper intake level (UL) for niacinamide. The UL of niacinamide during pregnancy and lactation is 30... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts that do not exceed the tolerable upper intake level (UL) for niacinamide. The UL of niacinamide during pregnancy and lactation is 30... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Aripiprazole Lauroxil and Niacinamide? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Aripiprazole Lauroxil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Aripiprazole Lauroxil is filed under 10 classifications — including alpha-adrenergic antagonists, antipsychotic drugs, qt interval-prolonging drugs. Niacinamide has documented interactions with 4 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), carbamazepine (tegretol) (moderate) and primidone (mysoline) (moderate) — and none of Aripiprazole Lauroxil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Niacinamide Does Interact With Other Medications

Niacinamide has 124 moderate known drug interactions in our database — Aripiprazole Lauroxil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 124 No known interaction 2,706 (incl. Aripiprazole Lauroxil)
Taking anything else?

Check Another of Your Medications Against Niacinamide

Covers the 2,830 medications we’ve checked against Niacinamide. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Niacinamide and Aripiprazole Lauroxil May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Drowsiness / Dizziness Additional detail

    Niacinamide

    “Orally, large doses of niacinamide can cause dizziness, drowsiness, and headaches.”

    Niacinamide · Natural Medicines adverse-effect record, reported in vertigo.

    5 sources cited
    1. 11694. Anon. Niacinamide Monograph. Alt Med Rev 2002;7:525-9.
    2. 11695. Miralbell R, Mornex F, Greiner R, et al. Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933. J Clin Oncol 1999;17:3143-9. PubMed
    3. 11696. Fatigante L, Ducci F, Cartei F, et al. Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: a new modality treatment. Int J Radiat Oncol Biol Phys 1997;37:499-504. PubMed
    4. 11697. Hoskin PJ, Stratford MR, Saunders MI, et al. Administration of nicotinamide during chart: pharmacokinetics, dose escalation, and clinical toxicity. Int J Radiat Oncol Biol Phys 1995;32:1111-9. PubMed
    5. 107709. Ketteler M, Wiecek A, Rosenkranz AR, et al. Efficacy and Safety of a Novel Nicotinamide Modified-Release Formulation in the Treatment of Refractory Hyperphosphatemia in Patients Receiving Hemodialysis-A Randomized Clinical Trial. Kidney Int Rep 2020;6(3): PubMed

    Aripiprazole Lauroxil

    Listed in the ADVERSE REACTIONS section of the FDA label for Aripiprazole Lauroxil. Read the label on DailyMed ›

  • Stomach upset Additional detail

    Niacinamide

    “Orally, large doses of niacinamide can cause gastrointestinal disturbances including nausea, vomiting, heartburn, anorexia, epigastric pain, flatulence, and diarrhea.”

    Niacinamide · Natural Medicines adverse-effect record, reported in anorexia.

    6 sources cited
    1. 6243. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
    2. 11694. Anon. Niacinamide Monograph. Alt Med Rev 2002;7:525-9.
    3. 11695. Miralbell R, Mornex F, Greiner R, et al. Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933. J Clin Oncol 1999;17:3143-9. PubMed
    4. 11696. Fatigante L, Ducci F, Cartei F, et al. Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: a new modality treatment. Int J Radiat Oncol Biol Phys 1997;37:499-504. PubMed
    5. 11697. Hoskin PJ, Stratford MR, Saunders MI, et al. Administration of nicotinamide during chart: pharmacokinetics, dose escalation, and clinical toxicity. Int J Radiat Oncol Biol Phys 1995;32:1111-9. PubMed
    6. 107709. Ketteler M, Wiecek A, Rosenkranz AR, et al. Efficacy and Safety of a Novel Nicotinamide Modified-Release Formulation in the Treatment of Refractory Hyperphosphatemia in Patients Receiving Hemodialysis-A Randomized Clinical Trial. Kidney Int Rep 2020;6(3): PubMed

    Aripiprazole Lauroxil

    Listed in the ADVERSE REACTIONS section of the FDA label for Aripiprazole Lauroxil. Read the label on DailyMed ›

  • Diarrhea / Vomiting Additional detail

    Niacinamide

    Recorded for Niacinamide in the same Natural Medicines adverse-effect record shown under Stomach upset above.

    Aripiprazole Lauroxil

    Listed in the ADVERSE REACTIONS section of the FDA label for Aripiprazole Lauroxil. Read the label on DailyMed ›

Reported for Niacinamide but not commonly for Aripiprazole Lauroxil: a low platelet count, bloating or gas, a skin rash and heartburn.

Effects for Aripiprazole Lauroxil come from the ADVERSE REACTIONS section of its FDA label; effects for Niacinamide come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 4,532 voluntary FDA FAERS reports for Aripiprazole Lauroxil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Niacinamide in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts that do not exceed the tolerable upper intake level (UL) for niacinamide. The UL of niacinamide during pregnancy and lactation is 30 mg daily for those 14-18 years of age and 35 mg daily for those 19 years and older. There is insufficient reliable information available about the safety of larger oral doses of niacinamide or topical niacinamide; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Aripiprazole Lauroxil Is Prescribed For, and What Niacinamide Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Aripiprazole Lauroxil is a prescription medicine with approved uses on its FDA label. Niacinamide is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Aripiprazole Lauroxil is prescribed for: Aripiprazole injection is used to treat schizophrenia and to provide maintenance treatment for bipolar I disorder in adults. Different injectable products carry these approvals. Abilify Asimtufii is approved for the treatment of schizophrenia in adults and as maintenance monotherapy for bipolar I disorder in adults. Aristada is approved for the treatment of schizophrenia in adults, with Aristada Initio used specifically to help start Aristada therapy.

Niacinamide has been studied for:

  • Depression studied, not established Niacinamide has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Niacinamide for depression

    Although there is interest in using oral niacinamide for depression, there is insufficient reliable information about the clinical effects of niacinamide for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Aripiprazole Lauroxil on your own; if you are taking Niacinamide for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Aripiprazole Lauroxil

This page covers Niacinamide only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aripiprazole Lauroxil page lists 233 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 16 major · 187 moderate · 30 minor.

From our pharmacist’s overview on the Aripiprazole Lauroxil page

“Aripiprazole lauroxil (Aristada) is a long-acting antipsychotic injection, and because each dose keeps working for weeks, a bad supplement pairing cannot be undone by skipping a pill. So the 16 major-rated entries among its 233 interactions on file deserve to be understood first.”

Reviewed by 2 · Jul 18, 2026

Open the Aripiprazole Lauroxil interaction page

One more smart check

Taking Niacinamide as Part of a Dietary Supplement Product? Check It for Interactions

We hold 552 real supplement products containing Niacinamide, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Niacinamide. Even though Niacinamide itself has no known interaction with Aripiprazole Lauroxil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Niacinamide and Aripiprazole Lauroxil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Niacinamide
Top 25%

#307 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aripiprazole Lauroxil
Steady interest

#1,458 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Niacinamide reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Niacinamide and Aripiprazole Lauroxil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Niacinamide

What is Niacinamide?

  • Acne and skin health
  • Pellagra (niacin deficiency)
  • Anti-aging and skin tone
  • Rosacea
  • Protecting against certain skin cancers

Niacinamide (also called nicotinamide) is a form of vitamin B3 used in supplements and skin-care products. It is well established for preventing and treating vitamin B3 deficiency, and there is moderate evidence for some skin uses, but many popular claims are still being studied. It is generally well tolerated at usual doses, but high amounts should be discussed with your doctor or pharmacist.

Not applicable (a form of vitamin B3) · Tablets, capsules, powders, topical creams and serums

An interaction check asks whether these two react with each other — it does not ask whether Niacinamide is a good idea for someone in your situation. Here is what our Niacinamide record says about it on its own.

Niacinamide: dosing

There is no single standardized supplement dose that fits everyone, and the right amount depends on why it is being used and your age and health. For preventing deficiency, intake is usually covered by a normal diet or a standard multivitamin.Skin products and oral supplements vary widely in strength. Do not assume more is better.

From our Niacinamide monograph — the full record covers uses, side effects and every documented interaction.

Read the full Niacinamide monograph & all interactions
Medication

About Aripiprazole Injection

What Is Aripiprazole Injection Used For?

Brand names: Aristada, Aristada Initio Kit

Aripiprazole injection is used to treat schizophrenia and to provide maintenance treatment for bipolar I disorder in adults. Different injectable products carry these approvals.

Abilify Asimtufii is approved for the treatment of schizophrenia in adults and as maintenance monotherapy for bipolar I disorder in adults. Aristada is approved for the treatment of schizophrenia in adults, with Aristada Initio used specifically to help start Aristada therapy.

Most-Reported Side Effects for Aripiprazole Lauroxil

From FAERS, the FDA’s public side-effect reporting system (4,532 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Needle issue 637 reports
Injection site pain 434 reports
Weight increased 215 reports
Product administered at inappropriate site 211 reports
Therapeutic response shortened 180 reports
See full Aripiprazole Injection drug information
Keep checking

Other Drugs & Niacinamide

Browse every other medication we’ve checked against Niacinamide — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
124Moderate
0Minor
2,705No known interaction
124 Moderate 2,705 No interaction
Moderate

124 interactions

Showing 60 of 124 moderate interactions — see all 124 on the Niacinamide page.

No interaction 2,705 drugs checked — show the list

We also checked Niacinamide against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,705 medications checked with no known interaction — see the full Niacinamide list.

See the full Niacinamide interactions page
See every supplement checked against Aripiprazole Lauroxil, ranked by severity
Evidence & sources

Niacinamide References

The 22 references that drive our Niacinamide monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pozzilli P, Browne PD, Kolb H. Meta-analysis of nicotinamide treatment in patients with recent-onset IDDM. The Nicotinamide Trialists. Diabetes Care 1996;19:1357-63. PubMed
  2. Greenbaum CJ, Kahn SE, Palmer JP. Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM. Diabetes 1996;45:1631-4. DOI
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Anon. Niacinamide Monograph. Alt Med Rev 2002;7:525-9.
  5. Miralbell R, Mornex F, Greiner R, et al. Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933. J Clin Oncol 1999;17:3143-9. PubMed
  6. Fatigante L, Ducci F, Cartei F, et al. Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: a new modality treatment. Int J Radiat Oncol Biol Phys 1997;37:499-504. PubMed
  7. Hoskin PJ, Stratford MR, Saunders MI, et al. Administration of nicotinamide during chart: pharmacokinetics, dose escalation, and clinical toxicity. Int J Radiat Oncol Biol Phys 1995;32:1111-9. PubMed
  8. Papa CM. Niacinamide and acanthosis nigricans (letter). Arch Dermatol 1984;120:1281. DOI
  9. Bourgeois BF, Dodson WE, Ferrendelli JA. Interactions between primidone, carbamazepine, and nicotinamide. Neurology 1982;32:1122-6.
  10. Visalli N, Cavallo MG, Signore A, et al. A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset type 1 diabetes (the IMDIAB VI). Diabetes Metab Res Rev 1999;15:181-5. DOI
  11. Rottembourg JB, Launay-Vacher V, Massard J. Thrombocytopenia induced by nicotinamide in hemodialysis patients. Kidney Int. 2005;68(6):2911-2. PubMed
  12. Fabbrocini G, Cantelli M, Monfrecola G. Topical nicotinamide for seborrheic dermatitis: an open randomized study. J Dermatolog Treat. 2014 Jun;25(3):241-5. PubMed
  13. Khodaeiani E, Fouladi RF, Amirnia M, Saeidi M, Karimi ER. Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. Int J Dermatol. 2013 Aug;52(8):999-1004. PubMed
  14. Zhang Y, Ma T, Zhang P. Efficacy and safety of nicotinamide on phosphorus metabolism in hemodialysis patients: A systematic review and meta-analysis. Medicine (Baltimore). 2018;97(41):e12731. PubMed
  15. Ketteler M, Wiecek A, Rosenkranz AR, et al. Efficacy and Safety of a Novel Nicotinamide Modified-Release Formulation in the Treatment of Refractory Hyperphosphatemia in Patients Receiving Hemodialysis-A Randomized Clinical Trial. Kidney Int Rep 2020;6(3): PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Niacinamide and Aripiprazole Lauroxil Together: Common Questions

Is it safe to take Niacinamide with Aripiprazole Lauroxil?
We do not list a known interaction between Niacinamide and Aripiprazole Lauroxil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Niacinamide and Aripiprazole Lauroxil have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Niacinamide and Aripiprazole Lauroxil used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Niacinamide in each. That is a conversation for your prescriber, especially if Aripiprazole Lauroxil is being adjusted to a target.
How was the Niacinamide and Aripiprazole Lauroxil combination checked?
Interactions in our licensed database are recorded against drug classes. Aripiprazole Lauroxil is filed under 10 classifications, and Niacinamide has documented interactions with 4 drug classes — none of Aripiprazole Lauroxil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Niacinamide interact with any other medications?
Yes. Niacinamide has 124 documented drug interactions in our database — Aripiprazole Lauroxil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Aripiprazole Lauroxil interact with any supplements?
Yes. Aripiprazole Lauroxil has documented interactions with 233 supplements in our database — Niacinamide is not one of them. The Aripiprazole Lauroxil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Niacinamide monograph Uses, safety profile, and every drug interaction in one place Aripiprazole Injection drug information The full plain-English guide to this medication Aripiprazole Lauroxil supplement interactions Every supplement checked against Aripiprazole Lauroxil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Aripiprazole Lauroxil and Niacinamide?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.