Drug & supplement interaction

Octacosanol + Mefloquine

Mefloquine brand name: Lariam.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Octacosanol and Mefloquine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mefloquine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Octacosanol and Mefloquine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mefloquine and Octacosanol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Octacosanol safety at a glance

Octacosanol overall Use caution Generally well tolerated in studied amounts, but long-term safety data are limited.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mefloquine and Octacosanol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mefloquine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mefloquine is filed under 2 classifications — seizure threshold lowering drugs, oral drugs. Octacosanol has documented interactions with 7 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and beta-blockers (moderate) — and none of Mefloquine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Octacosanol Does Interact With Other Medications

Octacosanol has 248 moderate known drug interactions in our database — Mefloquine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Mefloquine)
Taking anything else?

Check Another of Your Medications Against Octacosanol

Covers the 2,830 medications we’ve checked against Octacosanol. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Octacosanol and Mefloquine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Mood changes or irritability / Drowsiness / Trouble sleeping / Dizziness / Headache Additional detail

    Octacosanol

    “Octacosanol is the main component of policosanol. Orally, policosanol may cause headache, mild vertigo, somnolence, irritability, or insomnia, but these events are uncommon. It is unclear if octacosanol is the constituent responsible for these adverse effects.”

    Octacosanol · Natural Medicines adverse-effect record, reported in cluster headache.

    4 sources cited
    1. 14404. Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
    2. 65357. Menendez, R., Mas, R., Amor, A. M., Gonzalez, R. M., Fernandez, J. C., Rodeiro, I., Zayas, M., and Jimenez, S. Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modificat
    3. 69119. Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
    4. 95374. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed

    Mefloquine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mefloquine. Read the label on DailyMed ›

  • Itching / A skin rash Additional detail

    Octacosanol

    “Octacosanol is the main component of policosanol. Orally, policosanol can cause pruritus or skin rash, but these events appear to be uncommon. It is unclear if octacosanol is the constituent responsible for these adverse effects.”

    Octacosanol · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 65369. Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
    2. 95374. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed

    Mefloquine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mefloquine. Read the label on DailyMed ›

Effects for Mefloquine come from the ADVERSE REACTIONS section of its FDA label; effects for Octacosanol come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Mefloquine Products Have a Food Rule — Octacosanol Should Not Break It

At least one FDA label for a product containing Mefloquine says to take it on an empty stomach. Most supplements — Octacosanol included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Mefloquine on its own and move Octacosanol to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mefloquine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

The drug should not be taken on an empty stomach and should be administered with at least 8 oz (240 mL) of water.

From the Dosage and Administration section of the FDA label we read for Mefloquine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Mefloquine

This page covers Octacosanol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mefloquine page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).

By severity: 1 major · 13 moderate · 9 minor.

From our pharmacist’s overview on the Mefloquine page

“Mefloquine (Lariam) prevents and treats malaria and carries its own well-known warnings about seizures and psychiatric effects, so I take this interaction list more seriously than most. Six of the 23 supplements on file, including ginkgo and melatonin, may lower the seizure threshold, a poor match for a drug with mefloquine's neurologi…”

Reviewed by 2 · Jul 18, 2026

Open the Mefloquine interaction page

One more smart check

Taking Octacosanol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 435 real supplement products containing Octacosanol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Octacosanol. Even though Octacosanol itself has no known interaction with Mefloquine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Octacosanol and Mefloquine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Octacosanol
Top half

#489 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mefloquine
Steady interest

#1,551 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Octacosanol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Octacosanol and Mefloquine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Octacosanol

What is Octacosanol?

Octacosanol
  • Physical performance and endurance
  • Cholesterol support
  • Parkinson's and movement concerns
  • Antioxidant support
  • General energy and stamina

Octacosanol is a waxy long-chain alcohol from plant sources that is most often promoted for exercise endurance and cholesterol support, but solid human evidence is limited and results are mixed. It appears generally well tolerated in supplement amounts, but it is not a proven treatment for any condition, so talk with your pharmacist or doctor before using it.

Long-chain alcohol extracted from plant waxes (such as wheat germ oil, rice bran, and sugar cane wax) · Capsules, tablets, softgels; sometimes part of 'policosanol' blends

An interaction check asks whether these two react with each other — it does not ask whether Octacosanol is a good idea for someone in your situation. Here is what our Octacosanol record says about it on its own.

Octacosanol: dosing

There is no official or standardized dose of octacosanol. The amounts used in studies have varied widely, and there is not enough evidence to recommend a specific dose for any purpose.If you choose to try it, follow the directions on the product label and do not exceed the suggested amount. A pharmacist can help you review a product and decide whether it is appropriate for you.

From our Octacosanol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Octacosanol monograph & all interactions
Medication

About Mefloquine

What Is Mefloquine Used For?

Brand name: Lariam

Mefloquine Hydrochloride tablets are used to treat mild to moderate malaria caused by P. falciparum (including strains resistant to chloroquine) or P. vivax. They are also used to prevent malaria caused by these two parasite species, including chloroquine-resistant strains of P. falciparum, in people traveling to or living in areas where malaria is common.

Important note: Mefloquine does not eliminate the liver-stage parasites of P. vivax, so patients treated for P. vivax malaria will need a follow-up medication (such as primaquine) to prevent the infection from coming back. For life-threatening or severe malaria, an intravenous antimalarial is used first; mefloquine may then be given to complete the course.

See full Mefloquine drug information
Keep checking

Other Drugs & Octacosanol

Browse every other medication we’ve checked against Octacosanol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Octacosanol page.

No interaction 2,581 drugs checked — show the list

We also checked Octacosanol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Octacosanol list.

See the full Octacosanol interactions page
See every supplement checked against Mefloquine, ranked by severity
Evidence & sources

Octacosanol References

The 16 references that drive our Octacosanol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
  2. Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
  3. Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
  4. Snider S. Octacosanol in parkinsonism. Ann Neurol 1984;16:723. PubMed
  5. Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
  6. Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
  7. Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
  8. Menendez, R., Mas, R., Amor, A. M., Gonzalez, R. M., Fernandez, J. C., Rodeiro, I., Zayas, M., and Jimenez, S. Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modificat
  9. Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
  10. Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
  11. Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
  12. Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
  13. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
  14. Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
  15. Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Octacosanol and Mefloquine Together: Common Questions

Is it safe to take Octacosanol with Mefloquine?
We do not list a known interaction between Octacosanol and Mefloquine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Octacosanol and Mefloquine have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Octacosanol and Mefloquine at the same time of day?
At least one FDA label for a product containing Mefloquine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Mefloquine on its own and move Octacosanol to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Octacosanol and Mefloquine combination checked?
Interactions in our licensed database are recorded against drug classes. Mefloquine is filed under 2 classifications, and Octacosanol has documented interactions with 7 drug classes — none of Mefloquine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Octacosanol interact with any other medications?
Yes. Octacosanol has 248 documented drug interactions in our database — Mefloquine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mefloquine interact with any supplements?
Yes. Mefloquine has documented interactions with 23 supplements in our database — Octacosanol is not one of them. The Mefloquine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Octacosanol monograph Uses, safety profile, and every drug interaction in one place Mefloquine drug information The full plain-English guide to this medication Mefloquine supplement interactions Every supplement checked against Mefloquine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mefloquine and Octacosanol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.