Drug & supplement interaction

Octacosanol + Rilonacept

Rilonacept brand name: Arcalyst.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Octacosanol and Rilonacept in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Octacosanol and Rilonacept

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Rilonacept and Octacosanol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Octacosanol safety at a glance

Octacosanol overall Use caution Generally well tolerated in studied amounts, but long-term safety data are limited.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Rilonacept and Octacosanol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Octacosanol Does Interact With Other Medications

Octacosanol has 248 moderate known drug interactions in our database — Rilonacept isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Rilonacept)
Taking anything else?

Check Another of Your Medications Against Octacosanol

Covers the 2,830 medications we’ve checked against Octacosanol. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Octacosanol and Rilonacept May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching / A skin rash Additional detail

    Octacosanol

    “Octacosanol is the main component of policosanol. Orally, policosanol can cause pruritus or skin rash, but these events appear to be uncommon. It is unclear if octacosanol is the constituent responsible for these adverse effects.”

    Octacosanol · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 65369. Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
    2. 95374. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed

    Rilonacept

    Listed in the ADVERSE REACTIONS section of the FDA label for Rilonacept. Read the label on DailyMed ›

Reported for Octacosanol but not commonly for Rilonacept: mood changes or irritability, drowsiness, headache and trouble sleeping.

Effects for Rilonacept come from the ADVERSE REACTIONS section of its FDA label; effects for Octacosanol come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

One more smart check

Taking Octacosanol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 435 real supplement products containing Octacosanol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Octacosanol. Even though Octacosanol itself has no known interaction with Rilonacept, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Octacosanol and Rilonacept Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Octacosanol
Top half

#591 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rilonacept
Top half

#1,378 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Octacosanol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Octacosanol and Rilonacept records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Octacosanol

What is Octacosanol?

Octacosanol
  • Physical performance and endurance
  • Cholesterol support
  • Parkinson's and movement concerns
  • Antioxidant support
  • General energy and stamina

Octacosanol is a waxy long-chain alcohol from plant sources that is most often promoted for exercise endurance and cholesterol support, but solid human evidence is limited and results are mixed. It appears generally well tolerated in supplement amounts, but it is not a proven treatment for any condition, so talk with your pharmacist or doctor before using it.

Long-chain alcohol extracted from plant waxes (such as wheat germ oil, rice bran, and sugar cane wax) · Capsules, tablets, softgels; sometimes part of 'policosanol' blends

An interaction check asks whether these two react with each other — it does not ask whether Octacosanol is a good idea for someone in your situation. Here is what our Octacosanol record says about it on its own.

Octacosanol: dosing

There is no official or standardized dose of octacosanol. The amounts used in studies have varied widely, and there is not enough evidence to recommend a specific dose for any purpose.If you choose to try it, follow the directions on the product label and do not exceed the suggested amount. A pharmacist can help you review a product and decide whether it is appropriate for you.

From our Octacosanol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Octacosanol monograph & all interactions
Medication

About Rilonacept Injection

What Is Rilonacept Injection Used For?

Brand name: Arcalyst

Arcalyst (rilonacept) is approved to treat Cryopyrin-Associated Periodic Syndromes (CAPS) — including Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS) — in adults and children 12 and older. It is also used to maintain remission of Deficiency of Interleukin-1 Receptor Antagonist (DIRA) in adults and children weighing at least 10 kg (about 22 lbs).

Arcalyst is also approved to treat recurrent pericarditis (repeated episodes of inflammation around the heart) and to lower the risk of it coming back, in adults and children 12 and older.

Most-Reported Side Effects for Rilonacept

From FAERS, the FDA’s public side-effect reporting system (1,121 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Injection site erythema 132 reports
Chest pain 115 reports
Fatigue 89 reports
Injection site pain 87 reports
Pericarditis 84 reports
See full Rilonacept Injection drug information
Keep checking

Other Drugs & Octacosanol

Browse every other medication we’ve checked against Octacosanol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Octacosanol page.

No interaction 2,581 drugs checked — show the list

We also checked Octacosanol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Octacosanol list.

See the full Octacosanol interactions page
See every supplement checked against Rilonacept, ranked by severity
Evidence & sources

Octacosanol References

The 16 references that drive our Octacosanol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
  2. Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
  3. Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
  4. Snider S. Octacosanol in parkinsonism. Ann Neurol 1984;16:723. PubMed
  5. Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
  6. Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
  7. Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
  8. Menendez, R., Mas, R., Amor, A. M., Gonzalez, R. M., Fernandez, J. C., Rodeiro, I., Zayas, M., and Jimenez, S. Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modificat
  9. Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
  10. Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
  11. Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
  12. Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
  13. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
  14. Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
  15. Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Octacosanol and Rilonacept Together: Common Questions

Is it safe to take Octacosanol with Rilonacept?
We do not list a known interaction between Octacosanol and Rilonacept. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Octacosanol and Rilonacept have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Octacosanol interact with any other medications?
Yes. Octacosanol has 248 documented drug interactions in our database — Rilonacept is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Octacosanol monograph Uses, safety profile, and every drug interaction in one place Rilonacept Injection drug information The full plain-English guide to this medication Rilonacept supplement interactions Every supplement checked against Rilonacept, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Rilonacept and Octacosanol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.