Drug & supplement interaction

Pata De Vaca + Fruquintinib

Fruquintinib brand name: Fruzaqla.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Pata De Vaca and Fruquintinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pata De Vaca and Fruquintinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fruquintinib and Pata De Vaca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pata De Vaca safety at a glance

Pata De Vaca overall Use caution Limited human safety data, so use carefully and under professional guidance.

Pregnancy Avoid Not enough safety information; avoid during pregnancy.

Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fruquintinib and Pata De Vaca? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Fruquintinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fruquintinib is filed under 3 classifications — hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Pata De Vaca has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Fruquintinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pata De Vaca Does Interact With Other Medications

Pata De Vaca has 86 moderate known drug interactions in our database — Fruquintinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Fruquintinib)

Taking anything else?

Check Another of Your Medications Against Pata De Vaca

Covers the 2,830 medications we’ve checked against Pata De Vaca. Pick one to open its full report.

What to actually watch for

What Fruquintinib’s Own FDA Label Lists

This is not an interaction — none of it involves Pata De Vaca. These are the most notable effects listed in the ADVERSE REACTIONS section of Fruquintinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

A change in thyroid levels Worth acting on
Kidney problems Worth acting on
Raised blood pressure Worth acting on
Liver problems Worth acting on
Bleeding or bruising Worth acting on
A higher chance of infection Worth acting on
Mouth irritation or sores
Joint pain
Muscle pain
Stomach pain

Showing the 10 most notable of 13 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Fruquintinib. Read the label on DailyMed › Pata De Vaca’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pata De Vaca side to compare — that is a limit of the record, not a statement that Pata De Vaca has no side effects.

Everything else you take

See Every Supplement That Interacts With Fruquintinib

This page covers Pata De Vaca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fruquintinib page lists 168 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 124 moderate · 38 minor.

From our pharmacist’s overview on the Fruquintinib page

“Fruquintinib (Fruzaqla) is an oral targeted therapy for advanced colorectal cancer, which means keeping its blood level steady is part of what makes it work, and I would treat this supplement list with genuine care. Of the 168 ingredients on file, the large majority interact through CYP3A4, the liver enzyme that clears the drug, so the…”

Reviewed by 2 · Jul 18, 2026

Open the Fruquintinib interaction page

One more smart check

Taking Pata De Vaca as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Pata De Vaca, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pata De Vaca. Even though Pata De Vaca itself has no known interaction with Fruquintinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pata De Vaca and Fruquintinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pata De Vaca

Steady interest

#908 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Fruquintinib

Top half

#1,201 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pata De Vaca reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Pata De Vaca and Fruquintinib records this page draws on were last updated July 3, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Pata De Vaca

What is Pata De Vaca?

Blood sugar support
Diabetes (traditional use)
Diuretic
Kidney and urinary health
General tonic

Pata de Vaca is a South American plant whose leaves are traditionally brewed as a tea to help support blood sugar, earning it the nickname 'vegetable insulin.' Human evidence is very limited, so it should not replace prescribed diabetes treatment. Talk to your pharmacist or doctor before using it, especially if you take blood-sugar medications.

Bauhinia forficata · Fabaceae · Leaves · Tea (infusion), capsules, dried leaf, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Pata De Vaca is a good idea for someone in your situation. Here is what our Pata De Vaca record says about it on its own.

Pata De Vaca: dosing

There is no established standardized dose for Pata de Vaca. Traditional use is mostly as a leaf tea, but the strength of teas and supplements varies widely between products.If you choose to use it, follow the directions on the product label and start low.

From our Pata De Vaca monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pata De Vaca monograph & all interactions

Medication

About Fruquintinib

What Is Fruquintinib Used For?

Brand name: Fruzaqla

Fruzaqla (fruquintinib) is used to treat adults with metastatic colorectal cancer (mCRC) — colorectal cancer that has spread to other parts of the body. It is specifically for patients who have already been treated with several standard chemotherapy regimens and other targeted therapies.

Fruzaqla is intended for patients who have previously received fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and — if their tumor is RAS wild-type and it is medically appropriate — an anti-EGFR therapy.

Most-Reported Side Effects for Fruquintinib

From FAERS, the FDA’s public side-effect reporting system (3,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 470 reports

Colorectal cancer metastatic 388 reports

Colon cancer 371 reports

Diarrhea 275 reports

Blood pressure increased 269 reports

See full Fruquintinib drug information

Keep checking

Other Drugs & Pata De Vaca

Browse every other medication we’ve checked against Pata De Vaca — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

86Moderate

0Minor

2,743No known interaction

86 Moderate 2,743 No interaction

Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Pata De Vaca page.

No interaction 2,743 drugs checked — show the list

We also checked Pata De Vaca against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Pata De Vaca list.

See the full Pata De Vaca interactions page

See every supplement checked against Fruquintinib, ranked by severity

Evidence & sources

Pata De Vaca References

The 8 references that drive our Pata De Vaca monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Russo EM, Reichelt AA, De Sa JR, et al. Clinical trial of Myrcia uniflora and Bauhinia forficata leaf extracts in normal and diabetic patients. Braz J Med Biol Res 1990;23(1):11-20.
da Cunha AM, Menon S, Menon R, et al. Hypoglycemic activity of dried extracts of Bauhinia forficata Link. Phytomedicine 2010;17(1):37-41. PubMed
Lino Cde S, Diogenes JP, Pereira BA, et al. Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats. Biol Pharm Bull 2004;27(1):125-7. PubMed
Silva FR, Szpoganicz B, Pizzolatti MG, et al. Acute effect of Bauhinia forficata on serum glucose levels in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2002;83(1-2):33-7. PubMed
Pepato MT, Keller EH, Baviera AM, et al. Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats. J Ethnopharmacol 2002;81(2):191-7. PubMed
Jorge AP, Horst H, de Sousa E, et al. Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle. Chem Biol Interact 2004;149(2-3):89-96. PubMed
de Sousa E, Zanatta L, Seifriz I, et al. Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves. J Nat Prod 2004;67(5):829-32.
Vasconcelos F, Sampaio SV, Garofalo MA, et al. Insulin-like effects of Bauhinia forficata aqueous extract upon Tityus serrulatus scorpion envenoming. J Ethnopharmacol 2004;95(2-3):385-92. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pata De Vaca and Fruquintinib Together: Common Questions

Is it safe to take Pata De Vaca with Fruquintinib?

We do not list a known interaction between Pata De Vaca and Fruquintinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Pata De Vaca and Fruquintinib combination checked?

Interactions in our licensed database are recorded against drug classes. Fruquintinib is filed under 3 classifications, and Pata De Vaca has documented interactions with 1 drug class — none of Fruquintinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Pata De Vaca interact with any other medications?

Yes. Pata De Vaca has 86 documented drug interactions in our database — Fruquintinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Fruquintinib interact with any supplements?

Yes. Fruquintinib has documented interactions with 168 supplements in our database — Pata De Vaca is not one of them. The Fruquintinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pata De Vaca monograph Uses, safety profile, and every drug interaction in one place Fruquintinib drug information The full plain-English guide to this medication Fruquintinib supplement interactions Every supplement checked against Fruquintinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fruquintinib and Pata De Vaca?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.