Drug & supplement interaction

Pau D'arco + Alemtuzumab

Alemtuzumab brand name: Campath.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Pau D'arco and Alemtuzumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pau D'arco and Alemtuzumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alemtuzumab and Pau D'arco in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pau D'arco safety at a glance

Pau D'arco overall Use caution May cause side effects at higher doses and human safety data is limited.

Pregnancy Possibly Unsafe When used orally in typical doses. Animal studies have found that lapachol, a constituent of pau d'arco, has teratogenic and abortifacient effects; avoid using.... Read the full pregnancy detail

Breastfeeding Avoid Not enough safety information is available, so avoid while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alemtuzumab and Pau D'arco? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Alemtuzumab

Interactions in our licensed database are recorded against drug classes, not just single drug names. Alemtuzumab is filed under 2 classifications — immunosuppressants, oral drugs. Pau D'arco has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Alemtuzumab’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pau D'arco Does Interact With Other Medications

Pau D'arco has 122 moderate known drug interactions in our database — Alemtuzumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Alemtuzumab)

Taking anything else?

Check Another of Your Medications Against Pau D'arco

Covers the 2,830 medications we’ve checked against Pau D'arco. Pick one to open its full report.

What to actually watch for

What Pau D'arco Itself Has Been Linked To

This is not an interaction — nothing below involves Alemtuzumab. It is the side-effect record for Pau D'arco on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Pau D'arco, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

Wheezing Worth acting on Additional detail
“Occupational exposure to sawdust from the pau d'arco tree and related species may cause asthma and dermatitis. The fresh sawdust can produce erythema and papules which progress to a severe weeping and crusting dermatitis.”

Pau D'arco · Natural Medicines adverse-effect record, reported in asthma.
1 source cited

92184. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.
Anemia / Bleeding or bruising Worth acting on Additional detail
“Orally, the lapachol constituent of pau d'arco, taken in doses above 1.5 grams daily, may cause anemia and increased risk of bleeding.”

Pau D'arco · Natural Medicines adverse-effect record, reported in anemia.
1 source cited

91939. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
Dizziness Additional detail
“Orally, the lapachol constituent of pau d'arco, taken in doses above 1.5 grams daily, may cause dizziness.”

Pau D'arco · Natural Medicines adverse-effect record, reported in vertigo.
1 source cited

91939. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
Diarrhea / Vomiting / Nausea Additional detail
“Orally, the lapachol constituent of pau d'arco, taken in doses above 1.5 grams daily, may cause severe nausea, vomiting, and diarrhea.”

Pau D'arco · Natural Medicines adverse-effect record, reported in diarrhea.
1 source cited

91939. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
A skin rash Additional detail

Recorded for Pau D'arco in the same Natural Medicines adverse-effect record shown under Wheezing above.

Everything above comes from the Natural Medicines adverse-effect record for Pau D'arco — expand a row for the licensed statement it rests on. We haven’t matched Alemtuzumab to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Alemtuzumab.

Special populations

Pau D'arco in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally in typical doses. Animal studies have found that lapachol, a constituent of pau d'arco, has teratogenic and abortifacient effects; avoid using. There is insufficient reliable information available about the safety of pau d'arco when used topically in pregnancy; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Alemtuzumab Is Prescribed For, and What Pau D'arco Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Alemtuzumab is a prescription medicine with approved uses on its FDA label. Pau D'arco is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Alemtuzumab is prescribed for: Alemtuzumab (brand name Lemtrada) is approved for adults with relapsing forms of multiple sclerosis (MS) — including relapsing-remitting MS and active secondary progressive MS. Because it carries serious risks, it is generally reserved for people who have already tried at least two other MS medications without adequate results. It is not recommended for people with clinically isolated syndrome (CIS), a first episode of MS-like symptoms, due to its risk profile.

Pau D'arco has been studied for:

Cancer studied, not established Pau D'arco has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Pau D'arco for cancer

Although there has been interest in using oral pau d'arco for cancer, there is insufficient reliable information about the clinical effects of pau d'arco for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Alemtuzumab on your own; if you are taking Pau D'arco for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Alemtuzumab

This page covers Pau D'arco only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alemtuzumab page lists 70 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate) and Andrographis (moderate).

By severity: 1 major · 59 moderate · 10 minor.

From our pharmacist’s overview on the Alemtuzumab page

“Alemtuzumab (Campath) works by knocking down part of the immune system, which is how it treats multiple sclerosis and certain leukemias. That mechanism makes this a list to approach with real seriousness, because most of it, 53 ingredients including ashwagandha and astragalus, may stimulate immune activity, and anything that revs the i…”

Reviewed by 2 · Jul 18, 2026

Open the Alemtuzumab interaction page

One more smart check

Taking Pau D'arco as Part of a Dietary Supplement Product? Check It for Interactions

We hold 707 real supplement products containing Pau D'arco, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pau D'arco. Even though Pau D'arco itself has no known interaction with Alemtuzumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pau D'arco and Alemtuzumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pau D'arco

Top 25%

#291 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Alemtuzumab

Steady interest

#1,514 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pau D'arco reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pau D'arco and Alemtuzumab records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Pau D'arco

What is Pau D'arco?

Infections (bacterial, fungal, yeast)
Inflammation
Immune support
Digestive complaints
Skin conditions

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human evidence is lacking, and safety concerns exist at higher doses, so it should be used cautiously and discussed with a pharmacist or doctor first.

Handroanthus impetiginosus · Bignoniaceae · Inner bark · Tea (decoction), capsules, tablets, liquid extracts, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Pau D'arco is a good idea for someone in your situation. Here is what our Pau D'arco record says about it on its own.

Pau D'arco: dosing

There is no well-established, standardized dose for pau d'arco. Products vary widely in strength and form, and the amount of active compounds can differ from one product to another.Because larger doses raise the risk of toxic effects, it is best to use the smallest reasonable amount, follow the directions on the product label, and not exceed them.

From our Pau D'arco monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pau D'arco monograph & all interactions

Medication

About Alemtuzumab Injection (Chronic Lymphocytic Leukemia)

What Is Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Used For?

Brand name: Campath

Alemtuzumab (brand name Lemtrada) is approved for adults with relapsing forms of multiple sclerosis (MS) — including relapsing-remitting MS and active secondary progressive MS. Because it carries serious risks, it is generally reserved for people who have already tried at least two other MS medications without adequate results.

It is not recommended for people with clinically isolated syndrome (CIS), a first episode of MS-like symptoms, due to its risk profile.

See full Alemtuzumab Injection (Chronic Lymphocytic Leukemia) drug information

Keep checking

Other Drugs & Pau D'arco

Browse every other medication we’ve checked against Pau D'arco — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

122Moderate

0Minor

2,707No known interaction

122 Moderate 2,707 No interaction

Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Pau D'arco page.

No interaction 2,707 drugs checked — show the list

We also checked Pau D'arco against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Pau D'arco list.

See the full Pau D'arco interactions page

See every supplement checked against Alemtuzumab, ranked by severity

Evidence & sources

Pau D'arco References

The 6 references that drive our Pau D'arco monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pau D'arco and Alemtuzumab Together: Common Questions

Is it safe to take Pau D'arco with Alemtuzumab?

We do not list a known interaction between Pau D'arco and Alemtuzumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Pau D'arco and Alemtuzumab used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Pau D'arco in each. That is a conversation for your prescriber, especially if Alemtuzumab is being adjusted to a target.

How was the Pau D'arco and Alemtuzumab combination checked?

Interactions in our licensed database are recorded against drug classes. Alemtuzumab is filed under 2 classifications, and Pau D'arco has documented interactions with 1 drug class — none of Alemtuzumab's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Pau D'arco interact with any other medications?

Yes. Pau D'arco has 122 documented drug interactions in our database — Alemtuzumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Alemtuzumab interact with any supplements?

Yes. Alemtuzumab has documented interactions with 70 supplements in our database — Pau D'arco is not one of them. The Alemtuzumab interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pau D'arco monograph Uses, safety profile, and every drug interaction in one place Alemtuzumab Injection (Chronic Lymphocytic Leukemia) drug information The full plain-English guide to this medication Alemtuzumab supplement interactions Every supplement checked against Alemtuzumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alemtuzumab and Pau D'arco?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.