Drug & supplement interaction

Pear + Aripiprazole

Aripiprazole brand names: Abilify, Abilify Mycite, Abilify Maintena.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pear and Aripiprazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pear and Aripiprazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Aripiprazole and Pear in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pear at all — not against Aripiprazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pear safety at a glance

Pear overall Generally safe Pear is widely eaten as a food and is safe for most people in normal dietary amounts.
Pregnancy Likely Safe When consumed in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When consumed in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Aripiprazole and Pear? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Aripiprazole’s Own FDA Label Lists

This is not an interaction — none of it involves Pear. These are the most notable effects listed in the ADVERSE REACTIONS section of Aripiprazole’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on mentioned in 3.3% of FDA reports for Aripiprazole
  • Mania or an unusually elevated mood Worth acting on
  • Trouble swallowing Worth acting on
  • Hallucinations Worth acting on
  • Seizures Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Weight gain mentioned in 6.4% of FDA reports for Aripiprazole

Showing the 10 most notable of 37 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Aripiprazole. Read the label on DailyMed › Where a percentage is shown, it is the share of 125,626 voluntary FDA FAERS reports for Aripiprazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pear’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pear side to compare — that is a limit of the record, not a statement that Pear has no side effects.

Special populations

Pear in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When consumed in amounts commonly found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Pear or Aripiprazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pear or Aripiprazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Aripiprazole

This page covers Pear only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aripiprazole page lists 250 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 17 major · 194 moderate · 39 minor.

From our pharmacist’s overview on the Aripiprazole page

“Aripiprazole (Abilify) is an antipsychotic prescribed for schizophrenia, bipolar disorder, and as an add-on for depression, and this is one of the lists I want readers to treat with real care. The biggest cluster changes how the body handles the drug itself: grapefruit can raise aripiprazole levels, while St.”

Reviewed by 2 · Jul 18, 2026

Open the Aripiprazole interaction page

One more smart check

Taking Pear as Part of a Dietary Supplement Product? Check It for Interactions

We hold 793 real supplement products containing Pear, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pear. Even though Pear itself has no known interaction with Aripiprazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pear and Aripiprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pear
Top half

#391 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aripiprazole
Top 25%

#538 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pear reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pear and Aripiprazole records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pear

What is Pear?

  • Digestive health and constipation
  • Hydration and general nutrition
  • Cough and sore throat (traditional)
  • Hangover relief (traditional)
  • Antioxidant and heart health support

Pear is a common, nutritious fruit that provides fiber, water, vitamin C, and antioxidants, and it is a healthy part of most diets. Beyond its value as a food, evidence for pears as a medicinal supplement for specific conditions is limited, so enjoy it as part of a balanced diet rather than a treatment. If you have allergies or specific health concerns, check with your pharmacist or doctor.

Pyrus communis · Rosaceae · Fruit (commonly); leaves and fruit peel are sometimes used in traditional preparations · Fresh fruit, juice, dried fruit, fruit extracts, and powders

An interaction check asks whether these two react with each other — it does not ask whether Pear is a good idea for someone in your situation. Here is what our Pear record says about it on its own.

Pear: dosing

There is no established "medicinal dose" for pear, because it is mainly a food. Most people simply eat pears as part of a normal diet, such as one or more pieces of fruit per day.For pear juice, dried pear, or pear supplements and extracts, there is no standardized dose backed by strong evidence. Keep in mind that whole pears also provide fiber that juices and extracts may lack.

From our Pear monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pear monograph & all interactions
Medication

About Aripiprazole

What Is Aripiprazole Used For?

Brand names: Abilify, Abilify Mycite, Abilify Maintena

Aripiprazole treats several mental health conditions. It is approved for schizophrenia, acute manic and mixed episodes of Bipolar I Disorder, and as an add-on to antidepressants for Major Depressive Disorder.

It is also used for irritability linked to autistic disorder and for Tourette's disorder — in both children and adults depending on the condition.

Most-Reported Side Effects for Aripiprazole

From FAERS, the FDA’s public side-effect reporting system (125,626 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Weight increased 8,027 reports
Anxiety 5,268 reports
Fatigue 4,437 reports
Suicidal ideation 4,154 reports
Depression 4,147 reports
See full Aripiprazole drug information
Keep checking

Other Drugs & Pear

Browse every other medication we’ve checked against Pear — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pear against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pear list.

See the full Pear interactions page
See every supplement checked against Aripiprazole, ranked by severity
Evidence & sources

Pear References

The 4 references that drive our Pear monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Conceição de Oliveira M, Sichieri R, Sanchez Moura A. Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutrition 2003;19:253-6. PubMed
  3. Nieman DC, Gillitt ND, Sha W, et al. Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery. J Proteome Res 2015;14(12):5367-77. doi: 10.1021/acs.jproteome.5b00909. PubMed
  4. Lee HS, Isse T, Kawamoto T, Baik HW, Park JY, Yang M. Effect of Korean pear (Pyrus pyrifolia cv. Shingo) juice on hangover severity following alcohol consumption. Food Chem Toxicol 2013;58:101-6. doi: 10.1016/j.fct.2013.04.007.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pear and Aripiprazole Together: Common Questions

Is it safe to take Pear with Aripiprazole?
We do not list a known interaction between Pear and Aripiprazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Aripiprazole interact with any supplements?
Yes. Aripiprazole has documented interactions with 250 supplements in our database — Pear is not one of them. The Aripiprazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pear monograph Uses, safety profile, and every drug interaction in one place Aripiprazole drug information The full plain-English guide to this medication Aripiprazole supplement interactions Every supplement checked against Aripiprazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Aripiprazole and Pear?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.