Drug & supplement interaction

Pheasant's Eye + Bumetanide (Oral)

Bumetanide (Oral) brand name: Bumex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Pheasant's Eye and Bumetanide (Oral) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pheasant's Eye and Bumetanide (Oral)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bumetanide (Oral) and Pheasant's Eye in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pheasant's Eye safety at a glance

Pheasant's Eye overall Avoid The plant is poisonous and contains potent heart-affecting compounds with a very narrow safety margin.
Pregnancy Likely Unsafe When used orally for self-medication. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally for self-medication. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bumetanide (Oral) and Pheasant's Eye? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Bumetanide (Oral)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Bumetanide (Oral) is filed under 3 classifications — antihypertensive drugs, nephrotoxic drugs, oral drugs. Pheasant's Eye has documented interactions with 7 drug classes — the most serious being digoxin (lanoxin) (major), corticosteroids (moderate) and diuretic drugs (moderate) — and none of Bumetanide (Oral)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pheasant's Eye Does Interact With Other Medications

Pheasant's Eye has 1 major, 155 moderate known drug interactions in our database — Bumetanide (Oral) isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 155 No known interaction 2,674 (incl. Bumetanide (Oral))
Taking anything else?

Check Another of Your Medications Against Pheasant's Eye

Covers the 2,830 medications we’ve checked against Pheasant's Eye. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Pheasant's Eye and Bumetanide (Oral) May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Vomiting / Nausea Additional detail

    Pheasant's Eye

    “Orally, pheasant's eye might be unsafe due to its cardiac glycoside constituents.

    Serious Adverse Effects (Rare):

    Orally: Theoretically, digitalis-like effects including cardiac arrhythmia, diarrhea, nausea, and vomiting.”

    Pheasant's Eye · Natural Medicines adverse-effect record, reported in arrhythmia.

    “Orally, adverse effects may include diarrhea, nausea, and vomiting (2). Pheasant's eye contains cardiac glycosides and can cause serious adverse effects when used orally without appropriate medical supervision (18,512,104545).”

    Pheasant's Eye · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 512. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
    4. 104545. Shang X, Miao X, Yang F, et al. The genus Adonis as an important cardiac folk medicine: A review of the ethnobotany, phytochemistry and pharmacology. Front Pharmacol. 2019;10:25. PubMed

    Bumetanide (Oral)

    Listed in the ADVERSE REACTIONS section of the FDA label for Bumetanide (Oral). Read the label on DailyMed ›

Reported for Pheasant's Eye but not commonly for Bumetanide (Oral): an irregular heartbeat.

Effects for Bumetanide (Oral) come from the ADVERSE REACTIONS section of its FDA label; effects for Pheasant's Eye come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Pheasant's Eye in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally for self-medication.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Bumetanide (Oral) Is Prescribed For, and What Pheasant's Eye Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Bumetanide (Oral) is a prescription medicine with approved uses on its FDA label. Pheasant's Eye is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Bumetanide (Oral) is prescribed for: Bumetanide treats edema — excess fluid that builds up in the body — caused by congestive heart failure, hepatic (liver) disease, and renal (kidney) disease, including a condition called nephrotic syndrome. This applies to the oral tablets (bumetanide and Bumex), the injection (Bumetanide Injection), and the nasal spray. Enbumyst (bumetanide nasal spray) is specifically approved for these same uses in adults. Enbumyst is not intended for long-term use and should be switched to an oral diuretic as soon as practical.

Pheasant's Eye has been studied for:

  • Heart failure studied, not established Pheasant's Eye has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Pheasant's Eye for heart failure

    Although there has been interest in using oral pheasant's eye for heart failure, there is insufficient reliable information about the clinical effects of pheasant's eye for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Bumetanide (Oral) on your own; if you are taking Pheasant's Eye for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Pheasant's Eye or Bumetanide (Oral)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pheasant's Eye or Bumetanide (Oral), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bumetanide (Oral)

This page covers Pheasant's Eye only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bumetanide (Oral) page lists 142 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Siberian Cocklebur (major).

By severity: 6 major · 114 moderate · 22 minor.

From our pharmacist’s overview on the Bumetanide (Oral) page

“If you take bumetanide (Bumex), a strong water pill for fluid buildup from heart failure, kidney, or liver disease, treat this page with real care, especially the six interactions rated major. Nearly all of the 142 ingredients here, 119 of them, act on blood pressure, either dropping it further alongside the drug or pushing it back up…”

Reviewed by 2 · Jul 18, 2026

Open the Bumetanide (Oral) interaction page

How much people look this up

Where Pheasant's Eye and Bumetanide (Oral) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pheasant's Eye
Steady interest

#1,431 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bumetanide (Oral)
Top 25%

#390 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pheasant's Eye reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pheasant's Eye and Bumetanide (Oral) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pheasant's Eye

What is Pheasant's Eye?

  • Heart failure symptoms
  • Irregular or weak heartbeat
  • Fluid retention (as a diuretic)
  • Nervous heart complaints
  • Mild anxiety with heart palpitations

Pheasant's Eye (Adonis vernalis) is a toxic plant that contains heart-acting compounds similar to those in foxglove. It has been used in traditional and old European medicine for heart problems, but it is poisonous and has a very narrow margin of safety. You should not use it on your own — it should only ever be considered under direct medical supervision, if at all.

Adonis vernalis · Ranunculaceae · Dried above-ground parts (herb), including flowers, stems, and leaves · Tincture, dried herb extract, and standardized preparations (historically); rarely available as a non-prescription supplement

An interaction check asks whether these two react with each other — it does not ask whether Pheasant's Eye is a good idea for someone in your situation. Here is what our Pheasant's Eye record says about it on its own.

Pheasant's Eye: dosing

There is no safe, established over-the-counter dose for Pheasant's Eye, and we will not suggest one. Because the plant is toxic and the gap between an active dose and a poisonous dose is very small, dosing was historically left to trained practitioners using standardized, carefully measured preparations.We do not recommend using this plant on your own. If a product containing it is ever offered to you, do not take it without first speaking to a doctor or pharmacist. Always follow professional medical guidance rather than a product label alone.

From our Pheasant's Eye monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pheasant's Eye monograph & all interactions
Medication

About Bumetanide

What Is Bumetanide Used For?

Brand name: Bumex

Bumetanide treats edema — excess fluid that builds up in the body — caused by congestive heart failure, hepatic (liver) disease, and renal (kidney) disease, including a condition called nephrotic syndrome. This applies to the oral tablets (bumetanide and Bumex), the injection (Bumetanide Injection), and the nasal spray.

Enbumyst (bumetanide nasal spray) is specifically approved for these same uses in adults. Enbumyst is not intended for long-term use and should be switched to an oral diuretic as soon as practical.

See full Bumetanide drug information
Keep checking

Other Drugs & Pheasant's Eye

Browse every other medication we’ve checked against Pheasant's Eye — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
155Moderate
0Minor
2,673No known interaction
1 Major 155 Moderate 2,673 No interaction
Major

1 interaction

Moderate

155 interactions

Showing 60 of 155 moderate interactions — see all 155 on the Pheasant's Eye page.

No interaction 2,673 drugs checked — show the list

We also checked Pheasant's Eye against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,673 medications checked with no known interaction — see the full Pheasant's Eye list.

See the full Pheasant's Eye interactions page
See every supplement checked against Bumetanide (Oral), ranked by severity
Evidence & sources

Pheasant's Eye References

The 7 references that drive our Pheasant's Eye monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Shang X, Miao X, Yang F, et al. The genus Adonis as an important cardiac folk medicine: A review of the ethnobotany, phytochemistry and pharmacology. Front Pharmacol. 2019;10:25. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pheasant's Eye and Bumetanide (Oral) Together: Common Questions

Is it safe to take Pheasant's Eye with Bumetanide (Oral)?
We do not list a known interaction between Pheasant's Eye and Bumetanide (Oral). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pheasant's Eye and Bumetanide (Oral) have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Pheasant's Eye and Bumetanide (Oral) used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Pheasant's Eye in each. That is a conversation for your prescriber, especially if Bumetanide (Oral) is being adjusted to a target.
How was the Pheasant's Eye and Bumetanide (Oral) combination checked?
Interactions in our licensed database are recorded against drug classes. Bumetanide (Oral) is filed under 3 classifications, and Pheasant's Eye has documented interactions with 7 drug classes — none of Bumetanide (Oral)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pheasant's Eye interact with any other medications?
Yes. Pheasant's Eye has 156 documented drug interactions in our database — Bumetanide (Oral) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Bumetanide (Oral) interact with any supplements?
Yes. Bumetanide (Oral) has documented interactions with 142 supplements in our database — Pheasant's Eye is not one of them. The Bumetanide (Oral) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pheasant's Eye monograph Uses, safety profile, and every drug interaction in one place Bumetanide drug information The full plain-English guide to this medication Bumetanide (Oral) supplement interactions Every supplement checked against Bumetanide (Oral), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bumetanide (Oral) and Pheasant's Eye?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.