Drug & supplement interaction

Phenethylamine (pea) + Liraglutide Recombinant

Liraglutide Recombinant brand name: Saxenda.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Phenethylamine (pea) and Liraglutide Recombinant in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Phenethylamine (pea) and Liraglutide Recombinant

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Liraglutide Recombinant and Phenethylamine (pea) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phenethylamine (pea) safety at a glance

Phenethylamine (pe... overall Use caution May affect heart rate and blood pressure, and human safety data for supplements is limited.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Liraglutide Recombinant and Phenethylamine (pea)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Liraglutide Recombinant

Interactions in our licensed database are recorded against drug classes, not just single drug names. Liraglutide Recombinant is filed under a single classification — antidiabetes drugs. Phenethylamine (pea) has documented interactions with 2 drug classes — the most serious being monoamine oxidase inhibitors (maois) (moderate) and serotonergic drugs (moderate) — and none of Liraglutide Recombinant’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phenethylamine (pea) Does Interact With Other Medications

Phenethylamine (pea) has 187 moderate known drug interactions in our database — Liraglutide Recombinant isn’t one of them. If you take anything else, check it against the full list below.

Moderate 187 No known interaction 2,643 (incl. Liraglutide Recombinant)
Taking anything else?

Check Another of Your Medications Against Phenethylamine (pea)

Covers the 2,830 medications we’ve checked against Phenethylamine (pea). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Phenethylamine (pea) and Liraglutide Recombinant May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Anxiety or restlessness Additional detail

    Phenethylamine (pea)

    “A case of anxiety and agitation has been reported for an individual who consumed a weight loss product containing phenethylamine 200-300 mg, caffeine 500-750 mg, bitter orange 400-600 mg, willow bark 150-225 mg, cayenne pepper 80-120 mg, 1,3-dimethyloamyloamine 70-105 mg, gooseberry extract 40-60 mg, bergamot orange 40-60 mg, and black pepper 10-15 mg, daily for 2 months.”

    Phenethylamine (pea) · Natural Medicines adverse-effect record, reported in anxiety.

    1 source cited
    1. 24343. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.

    Liraglutide Recombinant

    Listed in the ADVERSE REACTIONS section of the FDA label for Liraglutide Recombinant. Read the label on DailyMed ›

Reported for Phenethylamine (pea) but not commonly for Liraglutide Recombinant: a fast or pounding heartbeat and weight loss.

Effects for Liraglutide Recombinant come from the ADVERSE REACTIONS section of its FDA label; effects for Phenethylamine (pea) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Liraglutide Recombinant Is Prescribed For, and What Phenethylamine (pea) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Liraglutide Recombinant is a prescription medicine with approved uses on its FDA label. Phenethylamine (pea) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Liraglutide Recombinant is prescribed for: Saxenda is used alongside a reduced-calorie diet and increased physical activity for chronic weight management. It is approved for adults with a BMI of 30 or higher, or a BMI of 27 or higher if they also have at least one weight-related condition such as high blood pressure, type 2 diabetes, or dyslipidemia (abnormal cholesterol or fat levels). It is also approved for adolescents aged 12 and older who weigh more than 60 kg and meet certain BMI thresholds for obesity. Saxenda should not be used together with other liraglutide-containing products or any other GLP-1 receptor agonist.

Read the rest of what Liraglutide Recombinant is prescribed for

Its safety and effectiveness in combination with other prescription or over-the-counter weight-loss products have not been established.

Phenethylamine (pea) has been studied for:

  • Obesity studied, not established Phenethylamine (pea) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Phenethylamine (pea) for obesity

    Although there has been interest in using oral phenethylamine for obesity, there is insufficient reliable information about the clinical effects of phenethylamine for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Liraglutide Recombinant on your own; if you are taking Phenethylamine (pea) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Liraglutide Recombinant

This page covers Phenethylamine (pea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liraglutide Recombinant page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Liraglutide Recombinant page

“If you take liraglutide (Saxenda), handle this page with real care, because all 239 ingredients on it act on the same thing the drug does, your blood sugar. The one major entry, Siberian cocklebur, has caused severe hypoglycemia, dangerously low blood sugar, in people and should never be combined with a glucose-lowering medicine.”

Reviewed by 2 · Jul 18, 2026

Open the Liraglutide Recombinant interaction page

One more smart check

Taking Phenethylamine (pea) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 208 real supplement products containing Phenethylamine (pea), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phenethylamine (pea). Even though Phenethylamine (pea) itself has no known interaction with Liraglutide Recombinant, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phenethylamine (pea) and Liraglutide Recombinant Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phenethylamine (pea)
Top half

#423 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Liraglutide Recombinant
Top 10%

#259 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenethylamine (pea) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Phenethylamine (pea) and Liraglutide Recombinant records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phenethylamine (pea)

What is Phenethylamine (pea)?

Phenethylamine (pea)
  • Mood support
  • Focus and concentration
  • Energy and pre-workout boost
  • Feeling of well-being
  • Athletic performance

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement is very limited, and it may raise blood pressure or heart rate, so people with heart or blood pressure problems should be cautious and check with a pharmacist or doctor first.

Not a plant part; a naturally occurring monoamine compound (made in the body and found in some foods) · Capsules, tablets, powders (often combined with other ingredients in pre-workout or 'mood' and 'focus' supplements)

An interaction check asks whether these two react with each other — it does not ask whether Phenethylamine (pea) is a good idea for someone in your situation. Here is what our Phenethylamine (pea) record says about it on its own.

Phenethylamine (pea): dosing

There is no well-established or standardized dose for PEA supplements, and reliable studies on safe and effective amounts are lacking. Products vary widely in how much they contain and what else they are combined with.If you choose to try it, follow the directions on the product label and do not exceed the recommended amount.

From our Phenethylamine (pea) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phenethylamine (pea) monograph & all interactions
Medication

About Liraglutide Injection

What Is Liraglutide Injection Used For?

Brand name: Saxenda

Saxenda is used alongside a reduced-calorie diet and increased physical activity for chronic weight management. It is approved for adults with a BMI of 30 or higher, or a BMI of 27 or higher if they also have at least one weight-related condition such as high blood pressure, type 2 diabetes, or dyslipidemia (abnormal cholesterol or fat levels). It is also approved for adolescents aged 12 and older who weigh more than 60 kg and meet certain BMI thresholds for obesity.

Saxenda should not be used together with other liraglutide-containing products or any other GLP-1 receptor agonist. Its safety and effectiveness in combination with other prescription or over-the-counter weight-loss products have not been established.

See full Liraglutide Injection drug information
Keep checking

Other Drugs & Phenethylamine (pea)

Browse every other medication we’ve checked against Phenethylamine (pea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
187Moderate
0Minor
2,642No known interaction
187 Moderate 2,642 No interaction
Moderate

187 interactions

Showing 60 of 187 moderate interactions — see all 187 on the Phenethylamine (pea) page.

No interaction 2,642 drugs checked — show the list

We also checked Phenethylamine (pea) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,642 medications checked with no known interaction — see the full Phenethylamine (pea) list.

See the full Phenethylamine (pea) interactions page
See every supplement checked against Liraglutide Recombinant, ranked by severity
Evidence & sources

Phenethylamine (pea) References

The 9 references that drive our Phenethylamine (pea) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
  3. Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
  4. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
  5. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
  6. Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
  7. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
  8. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
  9. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phenethylamine (pea) and Liraglutide Recombinant Together: Common Questions

Is it safe to take Phenethylamine (pea) with Liraglutide Recombinant?
We do not list a known interaction between Phenethylamine (pea) and Liraglutide Recombinant. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Phenethylamine (pea) and Liraglutide Recombinant have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Phenethylamine (pea) and Liraglutide Recombinant used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Phenethylamine (pea) in each. That is a conversation for your prescriber, especially if Liraglutide Recombinant is being adjusted to a target.
How was the Phenethylamine (pea) and Liraglutide Recombinant combination checked?
Interactions in our licensed database are recorded against drug classes. Liraglutide Recombinant is filed under 1 classification, and Phenethylamine (pea) has documented interactions with 2 drug classes — none of Liraglutide Recombinant's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phenethylamine (pea) interact with any other medications?
Yes. Phenethylamine (pea) has 187 documented drug interactions in our database — Liraglutide Recombinant is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Liraglutide Recombinant interact with any supplements?
Yes. Liraglutide Recombinant has documented interactions with 239 supplements in our database — Phenethylamine (pea) is not one of them. The Liraglutide Recombinant interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phenethylamine (pea) monograph Uses, safety profile, and every drug interaction in one place Liraglutide Injection drug information The full plain-English guide to this medication Liraglutide Recombinant supplement interactions Every supplement checked against Liraglutide Recombinant, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Liraglutide Recombinant and Phenethylamine (pea)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.