Drug & supplement interaction

Phlorizin + Sonidegib Phosphate

Sonidegib Phosphate brand name: Odomzo.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Phlorizin and Sonidegib Phosphate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sonidegib Phosphate states a food rule worth keeping to.

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Interaction report

Phlorizin and Sonidegib Phosphate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sonidegib Phosphate and Phlorizin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phlorizin safety at a glance

Phlorizin overall Not established Human safety data for phlorizin supplements are very limited.
Pregnancy Avoid There is no reliable safety data, so it is best avoided in pregnancy.
Breastfeeding Avoid No safety information exists for nursing, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sonidegib Phosphate and Phlorizin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sonidegib Phosphate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sonidegib Phosphate is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Phlorizin has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Sonidegib Phosphate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phlorizin Does Interact With Other Medications

Phlorizin has 86 moderate known drug interactions in our database — Sonidegib Phosphate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Sonidegib Phosphate)
Taking anything else?

Check Another of Your Medications Against Phlorizin

Covers the 2,830 medications we’ve checked against Phlorizin. Pick one to open its full report.

What to actually watch for

What Sonidegib Phosphate’s Own FDA Label Lists

This is not an interaction — none of it involves Phlorizin. These are the most notable effects listed in the ADVERSE REACTIONS section of Sonidegib Phosphate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • High blood sugar Worth acting on
  • Anemia Worth acting on
  • A low white blood cell count Worth acting on
  • Changes to your period
  • A change in taste
  • Weight loss
  • Hair loss
  • Reduced appetite
  • Muscle pain
  • Itching

Showing the 10 most notable of 16 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Sonidegib Phosphate. Read the label on DailyMed › Phlorizin’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Phlorizin side to compare — that is a limit of the record, not a statement that Phlorizin has no side effects.

How to take them

Some Sonidegib Phosphate Products Have a Food Rule — Phlorizin Should Not Break It

At least one FDA label for a product containing Sonidegib Phosphate says to take it on an empty stomach. Most supplements — Phlorizin included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Sonidegib Phosphate on its own and move Phlorizin to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sonidegib Phosphate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended dosage: 200 mg orally once daily taken on an empty stomach, at least 1 hour before or 2 hours after a meal.

From the Dosage and Administration section of the FDA label we read for Sonidegib Phosphate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sonidegib Phosphate

This page covers Phlorizin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sonidegib Phosphate page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Sonidegib Phosphate page

“Grapefruit is the first thing to drop if you take sonidegib (Odomzo) for advanced basal cell skin cancer. It blocks the CYP3A4 enzyme your body uses to clear sonidegib, so the drug can build up along with its side effects.”

Reviewed by 2 · Jul 18, 2026

Open the Sonidegib Phosphate interaction page

One more smart check

Taking Phlorizin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Phlorizin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phlorizin. Even though Phlorizin itself has no known interaction with Sonidegib Phosphate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phlorizin and Sonidegib Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phlorizin
Steady interest

#751 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sonidegib Phosphate
Steady interest

#2,611 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phlorizin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Phlorizin and Sonidegib Phosphate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phlorizin

What is Phlorizin?

  • Blood sugar support
  • Diabetes research
  • Antioxidant
  • Weight management interest

Phlorizin is a natural plant compound (a dihydrochalcone) found in apple tree bark and other plants that has been studied mostly in the laboratory for its effects on blood sugar handling. There is no good human evidence that taking it as a supplement is safe or effective, and it is poorly absorbed when swallowed. Talk with your pharmacist or doctor before using any product containing it.

Root bark, bark, and leaves of apple trees and related Rosaceae plants · Purified compound (research chemical), capsules, powders

An interaction check asks whether these two react with each other — it does not ask whether Phlorizin is a good idea for someone in your situation. Here is what our Phlorizin record says about it on its own.

Phlorizin: dosing

There is no established or standardized dose of phlorizin for supplement use in humans. It has mainly been used in research settings at carefully controlled amounts, not as a routine oral supplement.If you choose to use a product that contains phlorizin or apple bark extract, follow the directions on the product label and do not exceed the recommended amount.

From our Phlorizin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phlorizin monograph & all interactions
Medication

About Sonidegib

What Is Sonidegib Used For?

Brand name: Odomzo

Odomzo (sonidegib) is used to treat adults with locally advanced basal cell carcinoma (BCC) — a type of skin cancer that has grown beyond what surgery or radiation can easily handle. Specifically, it is for BCC that has come back after surgery or radiation therapy, or for patients who are not candidates for those treatments.

See full Sonidegib drug information
Keep checking

Other Drugs & Phlorizin

Browse every other medication we’ve checked against Phlorizin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Phlorizin page.

No interaction 2,743 drugs checked — show the list

We also checked Phlorizin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Phlorizin list.

See the full Phlorizin interactions page
See every supplement checked against Sonidegib Phosphate, ranked by severity
Evidence & sources

Phlorizin References

The 1 references that drive our Phlorizin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chao EC, Henry RR. SGLT2 inhibition--a novel strategy for diabetes treatment. Nat Rev Drug Discov. 2010;9(7):551-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phlorizin and Sonidegib Phosphate Together: Common Questions

Is it safe to take Phlorizin with Sonidegib Phosphate?
We do not list a known interaction between Phlorizin and Sonidegib Phosphate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Phlorizin and Sonidegib Phosphate at the same time of day?
At least one FDA label for a product containing Sonidegib Phosphate says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Sonidegib Phosphate on its own and move Phlorizin to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Phlorizin and Sonidegib Phosphate combination checked?
Interactions in our licensed database are recorded against drug classes. Sonidegib Phosphate is filed under 2 classifications, and Phlorizin has documented interactions with 1 drug class — none of Sonidegib Phosphate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phlorizin interact with any other medications?
Yes. Phlorizin has 86 documented drug interactions in our database — Sonidegib Phosphate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sonidegib Phosphate interact with any supplements?
Yes. Sonidegib Phosphate has documented interactions with 138 supplements in our database — Phlorizin is not one of them. The Sonidegib Phosphate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phlorizin monograph Uses, safety profile, and every drug interaction in one place Sonidegib drug information The full plain-English guide to this medication Sonidegib Phosphate supplement interactions Every supplement checked against Sonidegib Phosphate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sonidegib Phosphate and Phlorizin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.