Pulsatilla + Entrectinib
Entrectinib brand name: Rozlytrek.
We found no known interaction between Pulsatilla and Entrectinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Pulsatilla and Entrectinib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Entrectinib and Pulsatilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Pulsatilla at all — not against Entrectinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pulsatilla safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Pulsatilla in Pregnancy & Breastfeeding
When used orally. The fresh or dried above ground parts are contraindicated due to abortifacient and teratogenic effects. ...when the fresh above ground parts are used topically. There is insufficient reliable information available about the safety of topical dried pulsatilla during pregnancy.
When the fresh above ground parts are used for oral or topical use. There is insufficient reliable information available about the safety of dried pulsatilla during breast-feeding.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Entrectinib
This page covers Pulsatilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Entrectinib page lists 175 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).
By severity: 11 major · 127 moderate · 37 minor.
From our pharmacist’s overview on the Entrectinib page
“Grapefruit tops my worry list for anyone taking entrectinib (Rozlytrek), a targeted cancer therapy cleared by the liver enzyme CYP3A4. 121 of the 175 supplement ingredients on this page can shift how that enzyme handles the drug.”
Reviewed by 2 · Jul 18, 2026
Taking Pulsatilla as Part of a Dietary Supplement Product? Check It for Interactions
We hold 65 real supplement products containing Pulsatilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pulsatilla. Even though Pulsatilla itself has no known interaction with Entrectinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Pulsatilla and Entrectinib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#848 of 1,452 supplements looked up here in the last 7 days
#1,026 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pulsatilla reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pulsatilla and Entrectinib records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pulsatilla
What is Pulsatilla?
- Menstrual and PMS-related complaints
- Anxiety, moodiness, and weepiness (traditional/homeopathic)
- Earache and cold symptoms (homeopathic)
- Eye irritation and sinus complaints
- Sleep and restlessness
Pulsatilla is a flowering plant in the buttercup family that is most often used today in homeopathic (highly diluted) preparations. The fresh plant is toxic and irritating, so it must never be eaten raw, and high-quality human evidence for its benefits is lacking. Talk with your pharmacist or doctor before using any Pulsatilla product, and avoid it during pregnancy and breastfeeding.
Pulsatilla vulgaris · Ranunculaceae · Aerial parts (dried whole flowering plant); used dried, never fresh · Homeopathic pellets and liquid dilutions, dried herb, tincture
An interaction check asks whether these two react with each other — it does not ask whether Pulsatilla is a good idea for someone in your situation. Here is what our Pulsatilla record says about it on its own.
Pulsatilla: dosing
There is no well-established, standardized dose of Pulsatilla for any health condition. Homeopathic products come in different potencies (such as 6C or 30C) and are dosed according to the label or a practitioner's directions, not by milligrams.Because the raw plant is toxic, you should never make or take a homemade preparation.
From our Pulsatilla monograph — the full record covers uses, side effects and every documented interaction.
About Entrectinib
What Is Entrectinib Used For?
Brand name: Rozlytrek
Rozlytrek (entrectinib) is used to treat adult patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC), as confirmed by an FDA-approved test. It is also approved for adult and pediatric patients older than 1 month of age who have solid tumors — any cancer type — that carry an NTRK gene fusion detected by an FDA-approved test, provided the tumor has no known acquired resistance mutation, is metastatic or cannot be surgically removed without severe harm, and has progressed after prior treatment or has no satisfactory alternative therapy.
The NTRK gene fusion approval in solid tumors was granted under accelerated approval, meaning it is based on tumor response rates. Continued approval may depend on results from confirmatory clinical trials.
Most-Reported Side Effects for Entrectinib
From FAERS, the FDA’s public side-effect reporting system (1,653 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Pulsatilla
Browse every other medication we’ve checked against Pulsatilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Pulsatilla against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pulsatilla list.
Pulsatilla References
The 3 references that drive our Pulsatilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Pulsatilla and Entrectinib Together: Common Questions
Is it safe to take Pulsatilla with Entrectinib?
Do Pulsatilla and Entrectinib have any of the same side effects?
Does Entrectinib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.