Drug & supplement interaction

Queen's Delight + Prednisone

Prednisone brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Queen's Delight and Prednisone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Prednisone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Queen's Delight and Prednisone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Prednisone and Queen's Delight in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Queen's Delight at all — not against Prednisone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Queen's Delight safety at a glance

Queen's Delight overall Use caution It contains irritant compounds and has little modern safety data, so use cautiously and under professional guidance.
Pregnancy Possibly Unsafe When the dried root preparations are used orally. ...when the dried or fresh root is used topically; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When the dried or fresh root are used topically. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Prednisone and Queen's Delight? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Queen's Delight and Prednisone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on Additional detail

    Queen's Delight

    “Orally, queen's delight can cause vomiting, diarrhea, and nausea (18,19). In large amounts, it may cause a burning sensation of the mouth, throat, diarrhea, nausea, vomiting, dysuria, aches and pains, pruritus, skin eruptions, cough, depression, fatigue, and perspiration (4).

    Topically, it may cause inflammation, swelling, and contact dermatitis (18,19).”

    Queen's Delight · Natural Medicines adverse-effect record, reported in cough.

    3 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
    3. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • Sweating / Tiredness / Swelling / Diarrhea / Nausea / A skin rash / Vomiting reported in 8.2% of FDA reports for Prednisone Additional detail

    Queen's Delight

    Recorded for Queen's Delight in the same Natural Medicines adverse-effect record shown under Low mood above.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Queen's Delight but not commonly for Prednisone: itching, pain or burning when passing urine and cough.

Effects for Prednisone come from the ADVERSE REACTIONS section of its FDA label; effects for Queen's Delight come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 491,135 voluntary FDA FAERS reports for Prednisone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Queen's Delight in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When the dried root preparations are used orally. ...when the dried or fresh root is used topically; avoid using.

Pregnancy Likely Unsafe

When the fresh root preparations are used orally.

Lactation Possibly Unsafe

When the dried or fresh root are used topically.

Lactation Likely Unsafe

When used orally; contraindicated.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Prednisone Products Have a Food Rule — Queen's Delight Should Not Break It

At least one FDA label for a product containing Prednisone says to take it with food. If you take Queen's Delight on an empty stomach out of habit, keep them separate — and take Prednisone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Prednisone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION Gastric irritation may be reduced if taken before, during, or immediately after meals or with food or milk.

From the Dosage and Administration section of the FDA label we read for Prednisone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Queen's Delight or Prednisone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Queen's Delight or Prednisone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Prednisone

This page covers Queen's Delight only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prednisone page lists 208 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 168 moderate · 36 minor.

From our pharmacist’s overview on the Prednisone page

“Prednisone (Deltasone) suppresses the immune system to control inflammation, and that mechanism shapes most of what can go wrong on this 208-ingredient list, which I read as one to approach carefully rather than casually. Four entries rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Prednisone interaction page

One more smart check

Taking Queen's Delight as Part of a Dietary Supplement Product? Check It for Interactions

We hold 14 real supplement products containing Queen's Delight, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Queen's Delight. Even though Queen's Delight itself has no known interaction with Prednisone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Queen's Delight and Prednisone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Queen's Delight
Top half

#615 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Prednisone
Top 1%

#22 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Queen's Delight reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Queen's Delight and Prednisone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Queen's Delight

What is Queen's Delight?

  • Skin conditions and 'blood purifying'
  • Chronic skin eruptions (eczema, psoriasis)
  • Syphilis and other infections (historical use)
  • Sore throat and respiratory complaints
  • Constipation (as a laxative)

Queen's Delight (Stillingia sylvatica) is a traditional North American herb once used as a 'blood purifier' and for skin and throat problems. There is very little modern scientific evidence to support these uses, and the plant contains irritating compounds that can cause significant side effects. Talk with a pharmacist or doctor before trying it.

Stillingia sylvatica · Euphorbiaceae · Root and dried root (sometimes the root resin/oil) · Dried root, tincture, fluid extract, capsules, and as part of traditional herbal blends

An interaction check asks whether these two react with each other — it does not ask whether Queen's Delight is a good idea for someone in your situation. Here is what our Queen's Delight record says about it on its own.

Queen's Delight: dosing

There is no well-established, standardized dose for Queen's Delight. Traditional herbalists used small amounts of the dried root, tincture, or fluid extract, but these doses were not tested in modern clinical studies.If you choose to use a product, follow the directions on the label and do not exceed them. Because the herb can be irritating, starting low and using it only briefly is wise.

From our Queen's Delight monograph — the full record covers uses, side effects and every documented interaction.

Read the full Queen's Delight monograph & all interactions
Medication

About Prednisone

What Is Prednisone Used For?

Brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, Meticorten, Sterapred, Rayos

Prednisone treats a broad range of conditions where the body's immune system is overactive or inflammation needs to be controlled. It works across many organ systems, from the lungs and skin to the joints and blood.

Doctors prescribe it for conditions like asthma, severe allergies, Crohn's disease, multiple sclerosis flares, certain cancers, and to prevent organ rejection after transplant, among many others.

Most-Reported Side Effects for Prednisone

From FAERS, the FDA’s public side-effect reporting system (499,938 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 40,822 reports
Dyspnea 34,944 reports
Arthralgia 33,224 reports
Nausea 28,568 reports
Diarrhea 28,439 reports
See full Prednisone drug information
Keep checking

Other Drugs & Queen's Delight

Browse every other medication we’ve checked against Queen's Delight — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Queen's Delight against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Queen's Delight list.

See the full Queen's Delight interactions page
See every supplement checked against Prednisone, ranked by severity
Evidence & sources

Queen's Delight References

The 4 references that drive our Queen's Delight monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Queen's Delight and Prednisone Together: Common Questions

Is it safe to take Queen's Delight with Prednisone?
We do not list a known interaction between Queen's Delight and Prednisone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Queen's Delight and Prednisone have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Queen's Delight and Prednisone at the same time of day?
At least one FDA label for a product containing Prednisone says to take it with food. If you take Queen's Delight on an empty stomach out of habit, keep them separate and take Prednisone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Prednisone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Prednisone interact with any supplements?
Yes. Prednisone has documented interactions with 208 supplements in our database — Queen's Delight is not one of them. The Prednisone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Queen's Delight monograph Uses, safety profile, and every drug interaction in one place Prednisone drug information The full plain-English guide to this medication Prednisone supplement interactions Every supplement checked against Prednisone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Prednisone and Queen's Delight?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.