Drug & supplement interaction

Resveratrol + Levobupivacaine

Levobupivacaine brand name: Chirocaine.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Levobupivacaine falls into 2 drug categories that Resveratrol can interact with; the most serious is rated moderate. Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Resveratrol and Levobupivacaine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Resveratrol interacts with whole categories of medication. Levobupivacaine falls into 2 of those categories, so it can interact with Resveratrol in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

1 of 2

Why this applies to Levobupivacaine

Levobupivacaine falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Resveratrol interacts with.

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Levobupivacaine (Chirocaine) is a local anesthetic, usually given by a doctor for nerve blocks or epidurals. Part of how your body clears it relies on a liver enzyme called CYP1A2. In test-tube studies, resveratrol can slow that enzyme down. In theory, that could let levobupivacaine linger a bit longer and raise its levels, which might mean a stronger or longer-lasting numbing effect or, in higher amounts, more risk of side effects like dizziness, a metallic taste, ringing in the ears, or heart rhythm changes.

Here's the reassuring part: this is only seen in lab research, never reported in real people, so it stays theoretical. Since this drug is given in a controlled medical setting, just tell your anesthesia team or pharmacist you take resveratrol so they're aware.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

2 of 2

Levobupivacaine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Levobupivacaine (Chirocaine) is a local anesthetic, the kind of numbing medication your doctor or surgeon injects during procedures or for pain control. Your liver clears it partly through an enzyme called CYP3A4. In lab dish studies, resveratrol can slow that same enzyme down, which in theory could let levobupivacaine linger a bit longer and raise the odds of side effects like dizziness, numbness around the mouth, or, rarely, heart rhythm or blood pressure changes.

Here's the reassuring part: this concern comes only from test-tube research, and actual human studies with resveratrol up to 3000 mg daily did not require dose changes for CYP3A4 medications. On top of that, levobupivacaine is usually given as a one-time dose by a professional who monitors you. Still, it's smart to mention any supplements you take to your anesthesiologist or pharmacist before a procedure.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  2. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  3. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Resveratrol Also Interacts With Other Medications

Resveratrol has 821 moderate known drug interactions in our database — the Levobupivacaine one above is among them. If you take anything else, check it against the full list below.

Moderate 821 No known interaction 2,009 (incl. Levobupivacaine)
Taking anything else?

Check Another of Your Medications Against Resveratrol

Covers the 2,830 medications we’ve checked against Resveratrol. Pick one to open its full report.

From our Q&A

Questions About Resveratrol or Levobupivacaine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Resveratrol or Levobupivacaine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Levobupivacaine

This page covers Resveratrol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levobupivacaine page lists 172 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Fever Bark (major), Grapefruit (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 124 moderate · 44 minor.

From our pharmacist’s overview on the Levobupivacaine page

“Levobupivacaine (Chirocaine) is a local anesthetic, injected for surgery, nerve blocks, and epidurals, and the 172 supplement interactions on file deserve genuine attention ahead of a procedure. Most of the list involves ingredients that change how the liver clears the drug, either raising its blood level toward toxicity or lowering it…”

Reviewed by 2 · Jul 18, 2026

Open the Levobupivacaine interaction page

One more smart check

Taking Resveratrol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,939 real supplement products containing Resveratrol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Resveratrol. Your product may carry other ingredients that interact with Levobupivacaine too, on top of Resveratrol — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Resveratrol and Levobupivacaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Resveratrol
Top 10%

#88 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levobupivacaine
Steady interest

#1,801 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Resveratrol

What is Resveratrol?

Resveratrol
  • Heart and blood vessel health
  • Antioxidant support
  • Anti-aging
  • Blood sugar and metabolic support
  • General anti-inflammatory support

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, strong human evidence for most uses is still limited. It appears generally well tolerated in supplement doses, but talk with your pharmacist or doctor before starting it.

Read the full Resveratrol monograph & all interactions
Keep checking

Other Drugs & Resveratrol

Browse every other medication we’ve checked against Resveratrol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
821Moderate
0Minor
2,008No known interaction
821 Moderate 2,008 No interaction
Moderate

821 interactions

Showing 60 of 821 moderate interactions — see all 821 on the Resveratrol page.

No interaction 2,008 drugs checked — show the list

We also checked Resveratrol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,008 medications checked with no known interaction — see the full Resveratrol list.

See the full Resveratrol interactions page
See every supplement checked against Levobupivacaine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Resveratrol monograph › Uses, safety, and every drug interaction in one place Levobupivacaine supplement interactions › Every supplement checked against Levobupivacaine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Resveratrol and Levobupivacaine Together: Common Questions

Can you take Resveratrol with Levobupivacaine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Resveratrol and Levobupivacaine?
Levobupivacaine belongs to more than one drug category, and Resveratrol interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Resveratrol and Levobupivacaine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Levobupivacaine and Resveratrol?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.