Drug & supplement interaction

Resveratrol + Tipiracil Hydrochloride, Trifluridine

Tipiracil Hydrochloride, Trifluridine brand name: Lonsurf.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Resveratrol and Tipiracil Hydrochloride, Trifluridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tipiracil Hydrochloride, Trifluridine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Resveratrol and Tipiracil Hydrochloride, Trifluridine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tipiracil Hydrochloride, Trifluridine and Resveratrol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Resveratrol safety at a glance

Resveratrol overall Use caution Generally well tolerated in typical supplement doses, but high doses may cause digestive upset and long-term safety is not fully known.
Pregnancy Likely Safe When used in amounts found in foods. Resveratrol is found in grape skins, grape juice, wine, and other food sources. However, wine should not be used as a sourc... Read the full pregnancy detail
Breastfeeding Likely Safe When used in amounts found in foods. Resveratrol is found in grape skins, grape juice, wine, and other food sources. However, wine should not be used as a sourc... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tipiracil Hydrochloride, Trifluridine and Resveratrol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tipiracil Hydrochloride, Trifluridine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tipiracil Hydrochloride, Trifluridine is filed under a single classification — oral drugs. Resveratrol has documented interactions with 5 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 2c19 (cyp2c19) substrates (moderate) — and none of Tipiracil Hydrochloride, Trifluridine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Resveratrol Does Interact With Other Medications

Resveratrol has 824 moderate known drug interactions in our database — Tipiracil Hydrochloride, Trifluridine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 824 No known interaction 2,006 (incl. Tipiracil Hydrochloride, Trifluridine)
Taking anything else?

Check Another of Your Medications Against Resveratrol

Covers the 2,830 medications we’ve checked against Resveratrol. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Resveratrol and Tipiracil Hydrochloride, Trifluridine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • A low platelet count / A low white blood cell count Worth acting on Additional detail

    Resveratrol

    “In one clinical study, a patient developed severe febrile leukopenia and thrombocytopenia after taking oral resveratrol 500 mg three times daily for 10 days. Upon re-exposure to resveratrol, febrile leukopenia recurred.”

    Resveratrol · Natural Medicines adverse-effect record, reported in leukopenia.

    1 source cited
    1. 109163. Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed

    Tipiracil Hydrochloride, Trifluridine

    Listed in the ADVERSE REACTIONS section of the FDA label for Tipiracil Hydrochloride, Trifluridine. Read the label on DailyMed ›

  • Fever Additional detail

    Resveratrol

    Recorded for Resveratrol in the same Natural Medicines adverse-effect record shown under A low platelet count / A low white blood cell count above.

    Tipiracil Hydrochloride, Trifluridine

    Listed in the ADVERSE REACTIONS section of the FDA label for Tipiracil Hydrochloride, Trifluridine. Read the label on DailyMed ›

  • Tiredness Additional detail

    Resveratrol

    “Orally, resveratrol has been associated with headache, fatigue, and memory loss in patients on peritoneal dialysis. The causality of these adverse effects has not been established.”

    Resveratrol · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 95830. Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed

    Tipiracil Hydrochloride, Trifluridine

    Listed in the ADVERSE REACTIONS section of the FDA label for Tipiracil Hydrochloride, Trifluridine. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Resveratrol

    “Orally, mild gastrointestinal discomfort with increased diarrhea or loose stools has been reported, especially when resveratrol is taken in doses of 2.5-5 grams daily.”

    Resveratrol · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 71042. la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
    2. 71052. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
    3. 91327. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
    4. 95830. Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed
    5. 109163. Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed
    6. 109164. McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep 2022;12(1):10978. PubMed

    Tipiracil Hydrochloride, Trifluridine

    Listed in the ADVERSE REACTIONS section of the FDA label for Tipiracil Hydrochloride, Trifluridine. Read the label on DailyMed ›

Reported for Resveratrol but not commonly for Tipiracil Hydrochloride, Trifluridine: stomach upset, muscle pain, memory problems and a skin rash.

Effects for Tipiracil Hydrochloride, Trifluridine come from the ADVERSE REACTIONS section of its FDA label; effects for Resveratrol come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Resveratrol in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used in amounts found in foods. Resveratrol is found in grape skins, grape juice, wine, and other food sources. However, wine should not be used as a source of resveratrol during pregnancy and lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Tipiracil Hydrochloride, Trifluridine Products Have a Food Rule — Resveratrol Should Not Break It

At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Resveratrol on an empty stomach out of habit, keep them separate — and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tipiracil Hydrochloride, Trifluridine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended Dosage : 35 mg/m 2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.

From the Dosage and Administration section of the FDA label we read for Tipiracil Hydrochloride, Trifluridine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Tipiracil Hydrochloride, Trifluridine Is Prescribed For, and What Resveratrol Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Tipiracil Hydrochloride, Trifluridine is a prescription medicine with approved uses on its FDA label. Resveratrol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Tipiracil Hydrochloride, Trifluridine is prescribed for: Trifluridine and tipiracil (sold as Lonsurf) treats two types of advanced cancer in adults. Both are used after other treatments have already been tried. Lonsurf is used for metastatic colorectal cancer, either alone or together with bevacizumab. It is also used for metastatic gastric or gastroesophageal junction adenocarcinoma (cancer where the stomach meets the esophagus).

Resveratrol has been studied for:

  • Cancer studied, not established Resveratrol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Resveratrol for cancer

    It is unclear if dietary resveratrol is beneficial for cancer prevention.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tipiracil Hydrochloride, Trifluridine on your own; if you are taking Resveratrol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Resveratrol or Tipiracil Hydrochloride, Trifluridine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Resveratrol or Tipiracil Hydrochloride, Trifluridine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tipiracil Hydrochloride, Trifluridine

This page covers Resveratrol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tipiracil Hydrochloride, Trifluridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Tipiracil Hydrochloride, Trifluridine interaction page

One more smart check

Taking Resveratrol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,939 real supplement products containing Resveratrol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Resveratrol. Even though Resveratrol itself has no known interaction with Tipiracil Hydrochloride, Trifluridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Resveratrol and Tipiracil Hydrochloride, Trifluridine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Resveratrol
Top 10%

#82 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tipiracil Hydrochloride, Trifluridine
Top 25%

#568 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Resveratrol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Resveratrol and Tipiracil Hydrochloride, Trifluridine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Resveratrol

What is Resveratrol?

Resveratrol
  • Heart and blood vessel health
  • Antioxidant support
  • Anti-aging
  • Blood sugar and metabolic support
  • General anti-inflammatory support

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, strong human evidence for most uses is still limited. It appears generally well tolerated in supplement doses, but talk with your pharmacist or doctor before starting it.

A plant compound found in grape skins, berries, peanuts, and Japanese knotweed · Capsules, tablets, softgels, powders

An interaction check asks whether these two react with each other — it does not ask whether Resveratrol is a good idea for someone in your situation. Here is what our Resveratrol record says about it on its own.

Resveratrol: dosing

There is no official standardized dose of resveratrol. Studies have used a wide range of amounts, and products on the market vary a lot in strength and quality.The best approach is to follow the directions on the product label and not exceed the recommended amount. Because supplements are not tightly regulated, choose products from reputable companies, ideally those that use third-party testing.

From our Resveratrol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Resveratrol monograph & all interactions
Medication

About Trifluridine and Tipiracil

What Is Trifluridine and Tipiracil Used For?

Brand name: Lonsurf

Trifluridine and tipiracil (sold as Lonsurf) treats two types of advanced cancer in adults. Both are used after other treatments have already been tried.

Lonsurf is used for metastatic colorectal cancer, either alone or together with bevacizumab. It is also used for metastatic gastric or gastroesophageal junction adenocarcinoma (cancer where the stomach meets the esophagus).

See full Trifluridine and Tipiracil drug information
Keep checking

Other Drugs & Resveratrol

Browse every other medication we’ve checked against Resveratrol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
824Moderate
0Minor
2,005No known interaction
824 Moderate 2,005 No interaction
Moderate

824 interactions

Showing 60 of 824 moderate interactions — see all 824 on the Resveratrol page.

No interaction 2,005 drugs checked — show the list

We also checked Resveratrol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,005 medications checked with no known interaction — see the full Resveratrol list.

See the full Resveratrol interactions page
See every supplement checked against Tipiracil Hydrochloride, Trifluridine, ranked by severity
Evidence & sources

Resveratrol References

The 24 references that drive our Resveratrol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
  2. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  3. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  4. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  5. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  6. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  7. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  8. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  9. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  10. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  11. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  12. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  13. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  14. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  15. la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Resveratrol and Tipiracil Hydrochloride, Trifluridine Together: Common Questions

Is it safe to take Resveratrol with Tipiracil Hydrochloride, Trifluridine?
We do not list a known interaction between Resveratrol and Tipiracil Hydrochloride, Trifluridine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Resveratrol and Tipiracil Hydrochloride, Trifluridine have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Resveratrol and Tipiracil Hydrochloride, Trifluridine at the same time of day?
At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Resveratrol on an empty stomach out of habit, keep them separate and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Tipiracil Hydrochloride, Trifluridine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Resveratrol and Tipiracil Hydrochloride, Trifluridine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Resveratrol in each. That is a conversation for your prescriber, especially if Tipiracil Hydrochloride, Trifluridine is being adjusted to a target.
How was the Resveratrol and Tipiracil Hydrochloride, Trifluridine combination checked?
Interactions in our licensed database are recorded against drug classes. Tipiracil Hydrochloride, Trifluridine is filed under 1 classification, and Resveratrol has documented interactions with 5 drug classes — none of Tipiracil Hydrochloride, Trifluridine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Resveratrol interact with any other medications?
Yes. Resveratrol has 824 documented drug interactions in our database — Tipiracil Hydrochloride, Trifluridine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tipiracil Hydrochloride, Trifluridine interact with any supplements?
Yes. Tipiracil Hydrochloride, Trifluridine has documented interactions with 17 supplements in our database — Resveratrol is not one of them. The Tipiracil Hydrochloride, Trifluridine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Resveratrol monograph Uses, safety profile, and every drug interaction in one place Trifluridine and Tipiracil drug information The full plain-English guide to this medication Tipiracil Hydrochloride, Trifluridine supplement interactions Every supplement checked against Tipiracil Hydrochloride, Trifluridine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 24 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tipiracil Hydrochloride, Trifluridine and Resveratrol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.