Sage + Belladonna, Caffeine, Ergotamine, Pentobarbital
Belladonna, Caffeine, Ergotamine, Pentobarbital brand name: Micomp PB.
Belladonna, Caffeine, Ergotamine, Pentobarbital falls into 4 drug categories that Sage can interact with; the most serious is rated moderate. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full interaction reportSage and Belladonna, Caffeine, Ergotamine, Pentobarbital
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Sage interacts with whole categories of medication. Belladonna, Caffeine, Ergotamine, Pentobarbital falls into 4 of those categories, so it can interact with Sage in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CNS DEPRESSANTS
1 of 4Why this applies to Belladonna, Caffeine, Ergotamine, Pentobarbital
Belladonna, Caffeine, Ergotamine, Pentobarbital falls under CNS DEPRESSANTS — the group Sage interacts with.
Some constituents of sage have CNS depressant activity.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The piece of your Micomp PB combo that matters most here is the pentobarbital, a barbiturate that calms the brain and can make you drowsy. Lab studies suggest some natural compounds in sage may also have a mild calming (CNS depressant) effect. In theory, pairing them could add up and leave you more sleepy, foggy, lightheaded, or unsteady than usual.
I want to be honest that this is a theoretical concern based only on lab and animal data, not real-world cases. A little sage in cooking is very unlikely to cause trouble. Concentrated sage extracts or the essential oil are where I'd be more cautious. Before adding a sage supplement, just run it by your pharmacist or doctor so they can look at your full medication list.
- Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003;75:651-9.. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 4Belladonna, Caffeine, Ergotamine, Pentobarbital also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP3A4. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination pill (Micomp PB) blends a few active ingredients, and one of them, ergotamine, is broken down by a liver enzyme called CYP3A4. Lab studies hint that water-based sage extracts might slow that same enzyme down. If that happened in real life, ergotamine could build up a bit, and that matters because ergotamine is touchy at high levels. Too much can cause nausea, tingling or coldness in the fingers and toes, and cramping from narrowed blood vessels.
Here's the reassuring part: this is only a theoretical, test-tube finding, and it has never actually been reported in people. A pinch of sage in your cooking is very unlikely to matter. Concentrated sage capsules or oil are a different story, so check with your pharmacist or doctor before adding those.
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Hellum, B. H. and Nilsen, O. G. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol. 2008;102(5):466-475.
ANTICHOLINERGIC DRUGS
3 of 4Belladonna, Caffeine, Ergotamine, Pentobarbital also falls under ANTICHOLINERGIC DRUGS.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for your Micomp PB. One of its ingredients, belladonna, works as an anticholinergic, meaning it blocks a body chemical called acetylcholine to help calm cramping and ease stomach or bladder spasms. In lab tests, sage seems to do the opposite, nudging acetylcholine levels back up. So in theory, taking concentrated sage could slightly work against the belladonna part and make it less effective, possibly meaning a bit more cramping or stomach discomfort.
I want to be honest though: this is only seen in test-tube studies, not in real people, so it's more of a theoretical concern than a proven problem. Everyday cooking with sage is very unlikely to matter. If you're using strong sage extracts or oils regularly, just mention it to your pharmacist or doctor so they can keep an eye on things.
- Orhan, I., Kartal, M., Kan, Y., and Sener, B. Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z.Naturforsch.C. 2008;63(7-8):547-553.
- Perry, N. S., Houghton, P. J., Theobald, A., Jenner, P., and Perry, E. K. In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol 2000;52(7):895-902.
- Savelev, S. U., Okello, E. J., and Perry, E. K. Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents. Phytother Res 2004;18(4):315-324.
- Kennedy, D. O., Pace, S., Haskell, C., Okello, E. J., Milne, A., and Scholey, A. B. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery. Neuropsychopharmacology 2006;31(4):84 PubMed
ANTICONVULSANTS
4 of 4Belladonna, Caffeine, Ergotamine, Pentobarbital also falls under ANTICONVULSANTS.
Some species of sage can cause convulsions when consumed in large quantities.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination product contains pentobarbital, a barbiturate that calms the nervous system and can act as a seizure threshold medicine. The concern with sage is mostly theoretical and comes from lab and animal work, not from solid human studies. The idea is that some sage species, especially in large or concentrated amounts, contain a compound called thujone that can actually lower the seizure threshold and may work against drugs meant to keep the nervous system steady.
In plain terms, heavy use of sage extracts or sage essential oil could, in theory, blunt the calming benefit of the pentobarbital here. The seasoning amount you cook with is very unlikely to cause any problem. If you use concentrated sage supplements or oils, check with your pharmacist or doctor first rather than stopping anything on your own.
- Perry NB, Anderson RE, Brennan NJ, et al. Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites. J Agric Food Chem 1999;47:2048-54..
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Sage Also Interacts With Other Medications
Sage has 1,295 moderate known drug interactions in our database — the Belladonna, Caffeine, Ergotamine, Pentobarbital one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Sage
We haven’t checked that one against Sage yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Sage. Pick one to open its full report.
See Every Supplement That Interacts With Belladonna, Caffeine, Ergotamine, Pentobarbital
This page covers Sage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Belladonna, Caffeine, Ergotamine, Pentobarbital page lists 290 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Ephedra (major) and Gamma-hydroxybutyrate (ghb) (major).
By severity: 15 major · 227 moderate · 48 minor.
From our pharmacist’s overview on the Belladonna, Caffeine, Ergotamine, Pentobarbital page
“People who take Micomp PB for migraines are often the same people reaching for an herbal sleep aid or a caffeinated energy product during a rough stretch, and with four drugs in one tablet (belladonna, caffeine, ergotamine, pentobarbital) nearly everything clashes with something. The 290 supplement ingredients on file here earn genuine…”
Reviewed by 2 · Jul 18, 2026
Open the Belladonna, Caffeine, Ergotamine, Pentobarbital interaction page
Taking Sage as Part of a Dietary Supplement Product? Check It for Interactions
We hold 718 real supplement products containing Sage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sage. Your product may carry other ingredients that interact with Belladonna, Caffeine, Ergotamine, Pentobarbital too, on top of Sage — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Sage and Belladonna, Caffeine, Ergotamine, Pentobarbital Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#240 of 1,452 supplements looked up here in the last 7 days
#211 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Sage
What is Sage?
- Sore throat and mouth irritation
- Digestive upset
- Excessive sweating
- Memory and thinking
- Menopause symptoms (hot flashes)
- General antioxidant support
Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some early research is encouraging for sore throat and menopausal hot flashes, but most uses are not well proven. Concentrated extracts and the essential oil should be used carefully because high doses contain a compound called thujone, which can be harmful.
Other Drugs & Sage
Browse every other medication we’ve checked against Sage — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,295 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Glycopyrrolate ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Ipratropium ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Procainamide ›
- Trimipramine ›
- Acetaminophen ›
Showing 60 of 1,295 moderate interactions — see all 1,295 on the Sage page.
No interaction 1,534 drugs checked — show the list
We also checked Sage against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Isotretinoin ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Methotrexate ›
- Amoxicillin ›
- Bupropion ›
- Levothyroxine, Liothyronine ›
- Bendamustine ›
- Azithromycin ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Amoxicillin, Clavulanate Potassium ›
- Acetylsalicylic Acid ›
- Cyclopentolate ›
- Cephalexin ›
- Ezetimibe ›
- Roxithromycin ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Levodopa ›
- Mitomycin ›
- Alginic Acid, Aluminum Hydroxide ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Magnesium Hydroxide (otc Drug) ›
- Dexmethylphenidate ›
- Levothyroxine Sodium ›
- Cefaclor ›
- Daptomycin ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Flutemetamol F-18 ›
- Acenocoumarol ›
- Articaine, Epinephrine ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Hydroxychloroquine ›
- Peginterferon Alfa-2a, Ribavirin ›
- Pegunigalsidase Alfa-iwxj ›
- Aminolevulinic Acid Hydrochloride ›
- Charcoal (otc Drug) ›
- Factor 7a ›
- Hexobarbitone ›
- Alendronate Sodium, Cholecalciferol ›
- Bentoquatam ›
- Aspirin, Butalbital ›
- Alpha-1 Proteinase Inhibitor ›
- Colistin, Neomycin, Hydrocortisone ›
- Rosuvastatin Calcium, Ezetimibe ›
- Birth Control Pills ›
- Alglucosidase Alpha ›
- Phenylephrine ›
- Abciximab ›
- Droxidopa ›
Showing the 60 most looked-up of 1,534 medications checked with no known interaction — see the full Sage list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Belladonna, Caffeine, Ergotamine, Pentobarbital Is Linked to Lower Levels of 2 Nutrients
Natural Medicines records Belladonna, Caffeine, Ergotamine, Pentobarbital as a medicine that can lower these. This is not an interaction with Sage — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Belladonna, Caffeine, Ergotamine, Pentobarbital nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Sage and Belladonna, Caffeine, Ergotamine, Pentobarbital Together: Common Questions
Can you take Sage with Belladonna, Caffeine, Ergotamine, Pentobarbital?
Why are there 4 interactions listed for Sage and Belladonna, Caffeine, Ergotamine, Pentobarbital?
How serious is the Sage and Belladonna, Caffeine, Ergotamine, Pentobarbital interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Belladonna, Caffeine, Ergotamine, Pentobarbital and Sage?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.