Medication interaction hub

What Supplements Interact with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Belladonna, Caffeine, Ergotamine, Pentobarbital brand name: Micomp PB. Every interaction below applies to the brands too.

290 Interactions 15 Major 227 Moderate 48 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Belladonna, Caffeine, Ergotamine, Pentobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Belladonna, Caffeine, Ergotamine, Pentobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People who take Micomp PB for migraines are often the same people reaching for an herbal sleep aid or a caffeinated energy product during a rough stretch, and with four drugs in one tablet (belladonna, caffeine, ergotamine, pentobarbital) nearly everything clashes with something. The 290 supplement ingredients on file here earn genuine wariness, 15 of them rated major. Sedating supplements and alcohol deepen the pentobarbital's drowsiness, stimulant herbs pile onto the caffeine and can raise blood pressure, and grapefruit boosts ergotamine levels by blocking the enzyme that clears it.

St. John's wort works the opposite way, speeding that same enzyme so the ergotamine may fall short when you need it, and drying anticholinergic herbs add to belladonna's dry mouth and blurred vision. Most of the 227 moderate entries repeat these patterns at lower intensity. Read the major-rated names first; nearly all of the real danger on this page sits with them.

— , Clinical Pharmacist · July 18, 2026

Major 15 Moderate 227 Minor 48 No known interaction 1,162

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Belladonna, Caffeine, Ergotamine, Pentobarbital: Top Interactions at a Glance

The Belladonna, Caffeine, Ergotamine, Pentobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 290 interacting ingredients — plus 1,162 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Belladonna, Caffeine, Ergotamine, Pentobarbital Combinations Today

The Belladonna, Caffeine, Ergotamine, Pentobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Adenosine + Belladonna, Caffeine, Ergotamine, Pentobarbitali

Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.

Read the full interaction Moderate Likelihood Probable Caffeine + Belladonna, Caffeine, Ergotamine, Pentobarbitali

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Glutamine + Belladonna, Caffeine, Ergotamine, Pentobarbitali

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.

Read the full interaction Minor Likelihood Unlikely Jequirity + Belladonna, Caffeine, Ergotamine, Pentobarbitali

In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Read the full interaction Minor Likelihood Possible Fucus Vesiculosus + Belladonna, Caffeine, Ergotamine, Pentobarbitali

Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Read the full interaction Moderate Likelihood Possible Shepherd's Purse + Belladonna, Caffeine, Ergotamine, Pentobarbitali

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Read the full interaction
The complete list

Every Supplement Checked Against Belladonna, Caffeine, Ergotamine, Pentobarbital

All 1,452 ingredients in our database, ranked by severity — 290 with a Belladonna, Caffeine, Ergotamine, Pentobarbital interaction on file and 1,162 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Belladonna, Caffeine, Ergotamine, Pentobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Adenosine with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.

Full Adenosine + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Caffeine with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Glutamine with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glutamine might antagonize the effects of anticonvulsant medications.

Full Glutamine + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Jequirity with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Fucus Vesiculosus with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Raspberry Ketone with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Rauwolscine with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.

Full Rauwolscine + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Resveratrol with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.

Full Resveratrol + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Rooibos with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Full Rooibos + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Saffron with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Sage with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Sassafras with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Sceletium with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Schizonepeta with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2.

Full Schizonepeta + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Securinega Suffruticosa with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Selenium with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, selenium might prolong the sedating effects of barbiturates.

Full Selenium + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Shepherd's Purse with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Skullcap with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Slippery Elm with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Belladonna, Caffeine, Ergotamine, Pentobarbital answer

Can you take Sodium Bicarbonate with Belladonna, Caffeine, Ergotamine, Pentobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking methylxanthines.

Full Sodium Bicarbonate + Belladonna, Caffeine, Ergotamine, Pentobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Belladonna, Caffeine, Ergotamine, Pentobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Belladonna, Caffeine, Ergotamine, Pentobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Belladonna, Caffeine, Ergotamine, Pentobarbital sits in 13 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Pentobarbital (Nembutal) 26 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

26 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Ergot Derivatives 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Belladonna, Caffeine, Ergotamine, Pentobarbital through this category.

Related: does Belladonna, Caffeine, Ergotamine, Pentobarbital deplete any nutrients?

Belladonna, Caffeine, Ergotamine, Pentobarbital has 2 reported nutrient associations in the research literature — see the Belladonna, Caffeine, Ergotamine, Pentobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Belladonna, Caffeine, Ergotamine, Pentobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Belladonna, Caffeine, Ergotamine, Pentobarbital.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Belladonna, Caffeine, Ergotamine, Pentobarbital-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Belladonna, Caffeine, Ergotamine, Pentobarbital.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Belladonna, Caffeine, Ergotamine, Pentobarbital & Supplements: Common Questions

What supplements interact with Belladonna, Caffeine, Ergotamine, Pentobarbital?
Our database currently documents 290 ingredients with a known Belladonna, Caffeine, Ergotamine, Pentobarbital interaction (15 major, 227 moderate, 48 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 290. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Belladonna, Caffeine, Ergotamine, Pentobarbital supplement interactions are the most serious?
The 15 major-rated combinations — led by Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Belladonna, Caffeine, Ergotamine, Pentobarbital?
Plenty of supplements coexist fine with Belladonna, Caffeine, Ergotamine, Pentobarbital; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Micomp PB have the same supplement interactions as Belladonna, Caffeine, Ergotamine, Pentobarbital?
Yes — Micomp PB all contain Belladonna, Caffeine, Ergotamine, Pentobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Belladonna, Caffeine, Ergotamine, Pentobarbital deplete any vitamins or nutrients?
It might — Belladonna, Caffeine, Ergotamine, Pentobarbital has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Belladonna, Caffeine, Ergotamine, Pentobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Belladonna, Caffeine, Ergotamine, Pentobarbital and my other medications?
This page covers Belladonna, Caffeine, Ergotamine, Pentobarbital against supplements and herbal ingredients. Checking Belladonna, Caffeine, Ergotamine, Pentobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.