Sage + Nebivolol Hydrochloride, Valsartan
Nebivolol Hydrochloride, Valsartan brand name: Byvalson.
Nebivolol Hydrochloride, Valsartan falls into 3 drug categories that Sage can interact with; the most serious is rated moderate. Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Read the full interaction reportSage and Nebivolol Hydrochloride, Valsartan
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Sage interacts with whole categories of medication. Nebivolol Hydrochloride, Valsartan falls into 3 of those categories, so it can interact with Sage in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ANTIHYPERTENSIVE DRUGS
1 of 3Why this applies to Nebivolol Hydrochloride, Valsartan
Nebivolol Hydrochloride, Valsartan falls under ANTIHYPERTENSIVE DRUGS — the group Sage interacts with.
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction. However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension. Until more is known, use with caution.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Byvalson combines two blood pressure medicines: nebivolol (a beta-blocker) and valsartan (an ARB). The concern here isn't about how your body breaks these drugs down. Instead, sage itself may nudge blood pressure on its own, and the lab and animal evidence points in both directions. Common sage seemed to lower blood pressure for a longer stretch, while Spanish sage actually raised it in some people. So sage could either add to your medication's effect or work against it.
If you take concentrated sage supplements or the essential oil regularly, you might notice dizziness, lightheadedness, or unusually high readings. This is theoretical and based on weak evidence, and normal cooking amounts are very unlikely to matter. Just check with your pharmacist or doctor before starting a sage supplement.
- Todorov S, Philianos S, Petkov V, et al. Experimental pharmacological study of three species from genus Salvia. Acta Physiol Pharmacol (Bulg) 1984;10:13-20.
- Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003;75:651-9.. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 3Nebivolol Hydrochloride, Valsartan also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Byvalson combines two medicines, and one of them, nebivolol, is partly cleared by a liver enzyme called CYP2D6. Lab studies hint that sage extracts may slow this enzyme down. If that happened in your body, nebivolol could build up a bit, which might make its blood-pressure-lowering effect stronger. In real life that could mean feeling dizzy, lightheaded, unusually tired, or noticing a slower heartbeat. The valsartan half isn't affected by this enzyme.
Here's the reassuring part: this is only seen in test-tube research and has never actually been reported in people. Cooking with sage is very unlikely to matter. Concentrated sage capsules or oils are the bigger question, so just mention them to your pharmacist or doctor before starting them.
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Hellum BH, Nilsen OG. The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Basic Clin Pharmacol Toxicol. 2007 Nov;101:350-8.
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
3 of 3Nebivolol Hydrochloride, Valsartan also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Byvalson combines two blood pressure medicines: nebivolol (a beta-blocker) and valsartan. Lab studies hint that concentrated sage may slow down a liver enzyme called CYP2C9. Since the valsartan part has some handling through this pathway, the theory is that sage could nudge its levels a bit higher. If that happened, you might notice a little extra blood pressure lowering, possibly dizziness, lightheadedness, or feeling unusually tired.
Here's the honest part: this is only a test-tube finding, and it has never actually been reported in people. A pinch of sage in your cooking is very unlikely to matter. Concentrated sage extracts or the essential oil are a different story. If you're considering a sage supplement, just check with your pharmacist or doctor first.
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Sage Also Interacts With Other Medications
Sage has 1,295 moderate known drug interactions in our database — the Nebivolol Hydrochloride, Valsartan one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Sage
We haven’t checked that one against Sage yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Sage. Pick one to open its full report.
See Every Supplement That Interacts With Nebivolol Hydrochloride, Valsartan
This page covers Sage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nebivolol Hydrochloride, Valsartan page lists 213 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).
By severity: 5 major · 173 moderate · 35 minor.
From our pharmacist’s overview on the Nebivolol Hydrochloride, Valsartan page
“Nebivolol with valsartan (Byvalson) packs two blood pressure medicines into one pill, and I would treat this list with genuine care, especially its handful of serious entries. Most of the interactions tug on blood pressure itself, some deepening the drop until dizziness or fainting becomes a risk, others, tyramine among them, pushing p…”
Reviewed by 2 · Jul 18, 2026
Open the Nebivolol Hydrochloride, Valsartan interaction page
Taking Sage as Part of a Dietary Supplement Product? Check It for Interactions
We hold 718 real supplement products containing Sage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sage. Your product may carry other ingredients that interact with Nebivolol Hydrochloride, Valsartan too, on top of Sage — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Sage and Nebivolol Hydrochloride, Valsartan Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#239 of 1,452 supplements looked up here in the last 7 days
#415 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Sage
What is Sage?
- Sore throat and mouth irritation
- Digestive upset
- Excessive sweating
- Memory and thinking
- Menopause symptoms (hot flashes)
- General antioxidant support
Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some early research is encouraging for sore throat and menopausal hot flashes, but most uses are not well proven. Concentrated extracts and the essential oil should be used carefully because high doses contain a compound called thujone, which can be harmful.
Other Drugs & Sage
Browse every other medication we’ve checked against Sage — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,295 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Glycopyrrolate ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Ipratropium ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Procainamide ›
- Trimipramine ›
- Acetaminophen ›
Showing 60 of 1,295 moderate interactions — see all 1,295 on the Sage page.
No interaction 1,534 drugs checked — show the list
We also checked Sage against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Isotretinoin ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Methotrexate ›
- Amoxicillin ›
- Bupropion ›
- Levothyroxine, Liothyronine ›
- Bendamustine ›
- Azithromycin ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Amoxicillin, Clavulanate Potassium ›
- Acetylsalicylic Acid ›
- Cyclopentolate ›
- Cephalexin ›
- Ezetimibe ›
- Roxithromycin ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Levodopa ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Alginic Acid, Aluminum Hydroxide ›
- Mitomycin ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Magnesium Hydroxide (otc Drug) ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Flutemetamol F-18 ›
- Cefaclor ›
- Daptomycin ›
- Acenocoumarol ›
- Articaine, Epinephrine ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Hydroxychloroquine ›
- Peginterferon Alfa-2a, Ribavirin ›
- Aminolevulinic Acid Hydrochloride ›
- Charcoal (otc Drug) ›
- Pegunigalsidase Alfa-iwxj ›
- Aspirin, Butalbital ›
- Factor 7a ›
- Hexobarbitone ›
- Alendronate Sodium, Cholecalciferol ›
- Alpha-1 Proteinase Inhibitor ›
- Bentoquatam ›
- Colistin, Neomycin, Hydrocortisone ›
- Rosuvastatin Calcium, Ezetimibe ›
- Birth Control Pills ›
- Alglucosidase Alpha ›
- Abciximab ›
- Phenylephrine ›
- Droxidopa ›
Showing the 60 most looked-up of 1,534 medications checked with no known interaction — see the full Sage list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Nebivolol Hydrochloride, Valsartan Is Linked to Lower Levels of One Nutrient
Natural Medicines records Nebivolol Hydrochloride, Valsartan as a medicine that can lower these. This is not an interaction with Sage — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Nebivolol Hydrochloride, Valsartan nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Sage and Nebivolol Hydrochloride, Valsartan Together: Common Questions
Can you take Sage with Nebivolol Hydrochloride, Valsartan?
Why are there 3 interactions listed for Sage and Nebivolol Hydrochloride, Valsartan?
How serious is the Sage and Nebivolol Hydrochloride, Valsartan interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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