Drug & supplement interaction

Sea Buckthorn + Selexipag

Selexipag brand name: Uptravi.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Selexipag falls into 2 drug categories that Sea Buckthorn can interact with; the most serious is rated moderate. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Sea Buckthorn and Selexipag

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Sea Buckthorn interacts with whole categories of medication. Selexipag falls into 2 of those categories, so it can interact with Sea Buckthorn in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 2

Why this applies to Selexipag

Selexipag falls under ANTIHYPERTENSIVE DRUGS — the group Sea Buckthorn interacts with.

Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Taking sea buckthorn appears to reduce blood pressure in some patients.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Selexipag (Uptravi): this medicine already works by relaxing the blood vessels in your lungs, and one common result is a drop in blood pressure. Sea buckthorn, when taken as a concentrated supplement, may gently lower blood pressure too. So the worry is simply additive, the two together could pull your pressure down a bit more than either alone.

In real life that might show up as lightheadedness, dizziness when you stand, headache, or feeling washed out. I'll be honest though, this concern is theoretical and based on how things work on paper, not strong studies. Eating the berries as food is unlikely to matter. Before starting a supplement, just check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chang BB, Wang F Xu TY Zhang QQ He J Zhang XJ Li J. Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine. 2009;9(11):1207-1213. DOI
Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

2 of 2

Selexipag also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that sea buckthorn fruit extracts can inhibit platelet aggregation and adhesion to collagen and fibrinogen.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind with Selexipag (Uptravi) and sea buckthorn. Selexipag itself works on blood vessels in your lungs, but it also has a mild effect on platelets (the cells that help your blood clot), much like other medicines in this anticoagulant and antiplatelet group. Sea buckthorn, in concentrated supplement form, may also make platelets a little less sticky.

Stacked together, the worry is a slightly higher chance of bruising more easily, nosebleeds, or bleeding that takes longer to stop. I'll be honest, this is mostly theoretical and based on limited research. Eating sea buckthorn berries or a little juice is unlikely to matter, but concentrated supplements are a different story. Please check with your pharmacist or doctor before adding it.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
  2. Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Sea Buckthorn Also Interacts With Other Medications

Sea Buckthorn has 288 moderate known drug interactions in our database — the Selexipag one above is among them. If you take anything else, check it against the full list below.

Moderate 288 No known interaction 2,542 (incl. Selexipag)
Taking anything else?

Check Another of Your Medications Against Sea Buckthorn

Covers the 2,830 medications we’ve checked against Sea Buckthorn. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Selexipag

This page covers Sea Buckthorn only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Selexipag page lists 291 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Danshen (major) and Piracetam (major).

By severity: 6 major · 258 moderate · 27 minor.

From our pharmacist’s overview on the Selexipag page

“People take selexipag (Uptravi) for pulmonary arterial hypertension, dangerously high pressure in the arteries of the lungs, and that diagnosis raises the stakes on this list of 291 interacting supplements. I would treat it with real vigilance.”

Reviewed by 2 · Jul 18, 2026

Open the Selexipag interaction page

One more smart check

Taking Sea Buckthorn as Part of a Dietary Supplement Product? Check It for Interactions

We hold 253 real supplement products containing Sea Buckthorn, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sea Buckthorn. Your product may carry other ingredients that interact with Selexipag too, on top of Sea Buckthorn — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sea Buckthorn and Selexipag Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sea Buckthorn
Top half

#423 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Selexipag
Top 25%

#318 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Sea Buckthorn

What is Sea Buckthorn?

Sea Buckthorn
  • Skin health and dryness
  • Dry eye symptoms
  • Digestive complaints
  • Heart and cholesterol support
  • General antioxidant and immune support

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses like dry skin and dry eye, but most claims are not yet proven. It is generally well tolerated as a food, but talk to your pharmacist before using concentrated supplements.

Read the full Sea Buckthorn monograph & all interactions
Medication

About Selexipag

What Is Selexipag Used For?

Brand name: Uptravi

Selexipag tablets are used to treat pulmonary arterial hypertension (PAH, WHO Group I) — a type of high blood pressure in the arteries of the lungs. The goal is to slow the disease from getting worse and to reduce the chances of being hospitalized because of PAH.

Uptravi (selexipag) tablets are approved for both adults and children aged 2 years and older. Uptravi for injection (intravenous) is also available for adult patients who are already on Uptravi tablets but temporarily cannot take medicine by mouth.

See full Selexipag drug information
Keep checking

Other Drugs & Sea Buckthorn

Browse every other medication we’ve checked against Sea Buckthorn — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
288Moderate
0Minor
2,541No known interaction
288 Moderate 2,541 No interaction
Moderate

288 interactions

Showing 60 of 288 moderate interactions — see all 288 on the Sea Buckthorn page.

No interaction 2,541 drugs checked — show the list

We also checked Sea Buckthorn against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,541 medications checked with no known interaction — see the full Sea Buckthorn list.

See the full Sea Buckthorn interactions page
See every supplement checked against Selexipag, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Sea Buckthorn monograph › Uses, safety, and every drug interaction in one place Selexipag supplement interactions › Every supplement checked against Selexipag, ranked by severity Selexipag drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Sea Buckthorn and Selexipag Together: Common Questions

Can you take Sea Buckthorn with Selexipag?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Sea Buckthorn and Selexipag?
Selexipag belongs to more than one drug category, and Sea Buckthorn interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Sea Buckthorn and Selexipag interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Selexipag and Sea Buckthorn?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.