Medication interaction hub

What Supplements Interact with Selexipag?

Selexipag brand name: Uptravi. Every interaction below applies to the brands too.

291 Interactions 6 Major 258 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Selexipag? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Selexipag against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People take selexipag (Uptravi) for pulmonary arterial hypertension, dangerously high pressure in the arteries of the lungs, and that diagnosis raises the stakes on this list of 291 interacting supplements. I would treat it with real vigilance. Most entries either add to bleeding risk, since selexipag also affects platelets, or push blood pressure lower or work against controlling it, and six carry a major rating.

A couple of those majors are worth knowing by name. Activated charcoal can soak up selexipag before it absorbs, so take charcoal products well apart from your dose and read its full entry. Danshen adds bleeding risk on top of the drug's own platelet effect. The 258 moderate and 27 minor entries include ordinary things like fish oil, which can lower blood pressure a bit further, so scan the list below for whatever already sits in your cabinet.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 258 Minor 27 No known interaction 1,161

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Selexipag: Top Interactions at a Glance

The Selexipag supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 291 interacting ingredients — plus 1,161 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Selexipag Combinations Today

The Selexipag + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Unlikely Green Tea + Selexipagi

Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Possible Marshmallow + Selexipagi

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Tree Of Heaven + Selexipagi

Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.

Read the full interaction Minor Likelihood Unlikely Tocotrienols + Selexipagi

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Blood Irradiation Therapy + Selexipagi

Preliminary clinical research suggests that blood irradiation therapy might reduce platelet aggregation.

Read the full interaction Moderate Likelihood Possible Chrysin + Selexipagi

Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Selexipag

All 1,452 ingredients in our database, ranked by severity — 291 with a Selexipag interaction on file and 1,161 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Selexipag?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Green Tea with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Green Tea + Selexipag answer

Can you take Marshmallow with Selexipag?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Selexipag answer

Can you take Tree Of Heaven with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or antic...

Full Tree Of Heaven + Selexipag answer

Can you take Tocotrienols with Selexipag?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Tocotrienols + Selexipag answer

Can you take Blood Irradiation Therapy with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that blood irradiation therapy might reduce platelet aggregation.

Full Blood Irradiation Therapy + Selexipag answer

Can you take Vitamin B6 with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Selexipag answer

Can you take Vitamin E with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Vitamin E + Selexipag answer

Can you take Wasabi with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Wasabi + Selexipag answer

Can you take White Horehound with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that taking white horehound extract lowers blood pressure.

Full White Horehound + Selexipag answer

Can you take White Pepper with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits platelet aggregation.

Full White Pepper + Selexipag answer

Can you take Yerba Mate with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Yerba Mate + Selexipag answer

Can you take Arnica with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Full Arnica + Selexipag answer

Can you take Blue-green Algae with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.

Full Blue-green Algae + Selexipag answer

Can you take Chinese Prickly Ash with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Chinese prickly ash might inhibit platelet aggregation.

Full Chinese Prickly Ash + Selexipag answer

Can you take Coffee with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coffee may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Coffee + Selexipag answer

Can you take Cola Nut with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cola nut may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cola Nut + Selexipag answer

Can you take Fenugreek with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.

Full Fenugreek + Selexipag answer

Can you take Forsythia with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking forsythia with anticoagulant or antiplatelet drugs might increase the risk of bleeding due to decreased platelet aggre...

Full Forsythia + Selexipag answer

Can you take Green Coffee with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green coffee may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Green Coffee + Selexipag answer

Can you take Ilex Guayusa with Selexipag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Ilex guayusa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Ilex Guayusa + Selexipag answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Selexipag is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Selexipag, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Selexipag sits in 4 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Selexipag through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Selexipag through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Selexipag through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Selexipag through this category.

About Selexipag

Selexipag is a prostacyclin receptor agonist used to treat pulmonary arterial hypertension (PAH) in adults and children aged 2 and older.

Generic name: Selexipag  ·  Brand name: Uptravi.

See the full Selexipag drug information

Related: does Selexipag deplete any nutrients?

Selexipag has 1 reported nutrient association in the research literature — see the Selexipag nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Selexipag

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Selexipag.

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Pharmacist Counseling Corner

Selexipag & Supplements: Common Questions

What supplements interact with Selexipag?
Our database currently documents 291 ingredients with a known Selexipag interaction (6 major, 258 moderate, 27 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 291. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Selexipag supplement interactions are the most serious?
Focus on the major group: American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Danshen, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Selexipag?
Plenty of supplements coexist fine with Selexipag; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Uptravi have the same supplement interactions as Selexipag?
Yes — Uptravi all contain Selexipag, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Selexipag deplete any vitamins or nutrients?
It might — Selexipag has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Selexipag nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Selexipag and my other medications?
This page covers Selexipag against supplements and herbal ingredients. Checking Selexipag against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Selexipag drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.