Drug & supplement interaction

Zedoary + Selexipag

Selexipag brand name: Uptravi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Zedoary and Selexipag in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Selexipag states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Zedoary and Selexipag

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Selexipag and Zedoary in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Zedoary safety at a glance

Zedoary overall Use caution Generally used in food amounts, but human safety data for supplement doses is limited.
Pregnancy Likely Unsafe When used orally. Zedoary is thought to have abortifacient effects; avoid using. Read the full pregnancy detail
Breastfeeding Avoid No reliable safety information during breastfeeding, so it is best avoided.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Selexipag and Zedoary? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Selexipag

Interactions in our licensed database are recorded against drug classes, not just single drug names. Selexipag is filed under 4 classifications — including cytochrome p450 2c8 (cyp2c8) substrates, anticoagulant/antiplatelet drugs, antihypertensive drugs. Zedoary has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Selexipag’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Zedoary Does Interact With Other Medications

Zedoary has 643 moderate known drug interactions in our database — Selexipag isn’t one of them. If you take anything else, check it against the full list below.

Moderate 643 No known interaction 2,187 (incl. Selexipag)
Taking anything else?

Check Another of Your Medications Against Zedoary

Covers the 2,830 medications we’ve checked against Zedoary. Pick one to open its full report.

What to actually watch for

What Selexipag’s Own FDA Label Lists

This is not an interaction — none of it involves Zedoary. These are the most notable effects listed in the ADVERSE REACTIONS section of Selexipag’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • A change in thyroid levels Worth acting on
  • Anemia Worth acting on
  • Pain in an arm or leg
  • Headache mentioned in 26.4% of FDA reports for Selexipag
  • Diarrhea mentioned in 20.3% of FDA reports for Selexipag
  • Flushing
  • Joint pain
  • Reduced appetite
  • Muscle pain
  • Nausea mentioned in 16.1% of FDA reports for Selexipag

Showing the 10 most notable of 13 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Selexipag. Read the label on DailyMed › Where a percentage is shown, it is the share of 25,258 voluntary FDA FAERS reports for Selexipag that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Zedoary’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Zedoary side to compare — that is a limit of the record, not a statement that Zedoary has no side effects.

Special populations

Zedoary in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Zedoary is thought to have abortifacient effects; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Selexipag Products Have a Food Rule — Zedoary Should Not Break It

At least one FDA label for a product containing Selexipag says to take it with food. If you take Zedoary on an empty stomach out of habit, keep them separate — and take Selexipag with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Selexipag products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Tolerability may be improved when taken with food [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Selexipag — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Selexipag

This page covers Zedoary only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Selexipag page lists 291 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Danshen (major) and Piracetam (major).

By severity: 6 major · 258 moderate · 27 minor.

From our pharmacist’s overview on the Selexipag page

“People take selexipag (Uptravi) for pulmonary arterial hypertension, dangerously high pressure in the arteries of the lungs, and that diagnosis raises the stakes on this list of 291 interacting supplements. I would treat it with real vigilance.”

Reviewed by 2 · Jul 18, 2026

Open the Selexipag interaction page

One more smart check

Taking Zedoary as Part of a Dietary Supplement Product? Check It for Interactions

We hold 83 real supplement products containing Zedoary, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Zedoary. Even though Zedoary itself has no known interaction with Selexipag, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Zedoary and Selexipag Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Zedoary
Top half

#684 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Selexipag
Steady interest

#1,760 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Zedoary reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Zedoary and Selexipag records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Zedoary

What is Zedoary?

  • Digestive upset and bloating
  • Loss of appetite
  • Menstrual discomfort
  • Inflammation and pain
  • Traditional flavoring and tonic

Zedoary is a ginger-family root used in traditional Asian and Indian medicine, mostly for digestion and as a spice. Scientific evidence in humans is very limited, so its benefits are not well proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy.

Curcuma zedoaria · Zingiberaceae · Rhizome (root) and essential oil · Dried powder, capsules, tinctures, essential oil, tea

An interaction check asks whether these two react with each other — it does not ask whether Zedoary is a good idea for someone in your situation. Here is what our Zedoary record says about it on its own.

Zedoary: dosing

There is no standardized, well-established dose for zedoary. The right amount depends on the form (powder, capsule, tincture, or oil) and the product's strength.The safest approach is to follow the directions on the product label and not exceed them.

From our Zedoary monograph — the full record covers uses, side effects and every documented interaction.

Read the full Zedoary monograph & all interactions
Medication

About Selexipag

What Is Selexipag Used For?

Brand name: Uptravi

Selexipag tablets are used to treat pulmonary arterial hypertension (PAH, WHO Group I) — a type of high blood pressure in the arteries of the lungs. The goal is to slow the disease from getting worse and to reduce the chances of being hospitalized because of PAH.

Uptravi (selexipag) tablets are approved for both adults and children aged 2 years and older. Uptravi for injection (intravenous) is also available for adult patients who are already on Uptravi tablets but temporarily cannot take medicine by mouth.

Most-Reported Side Effects for Selexipag

From FAERS, the FDA’s public side-effect reporting system (25,685 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 6,740 reports
Diarrhea 5,173 reports
Dyspnea 4,774 reports
Nausea 4,103 reports
Fatigue 2,601 reports
See full Selexipag drug information
Keep checking

Other Drugs & Zedoary

Browse every other medication we’ve checked against Zedoary — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
643Moderate
0Minor
2,186No known interaction
643 Moderate 2,186 No interaction
Moderate

643 interactions

Showing 60 of 643 moderate interactions — see all 643 on the Zedoary page.

No interaction 2,186 drugs checked — show the list

We also checked Zedoary against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Zedoary list.

See the full Zedoary interactions page
See every supplement checked against Selexipag, ranked by severity
Evidence & sources

Zedoary References

The 5 references that drive our Zedoary monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Tariq S, Imran M, Mushtaq Z, Asghar N. Phytopreventive antihypercholesterolemic and antilipidemic perspectives of zedoary (Curcuma Zedoaria Roscoe) herbal tea. Lipids Health Dis 2016;15:39. doi: 10.1186/s12944-016-0210-y.
  4. Rodseeda C, Yamanont P, Pinthong D, Korprasertthaworn P. Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib. Toxicol Rep 2022;9:1846-1852. PubMed
  5. Niu LQ, Xiao L, Cai QH, et al. Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis. Integr Med Res 2023;12(2):100944. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Zedoary and Selexipag Together: Common Questions

Is it safe to take Zedoary with Selexipag?
We do not list a known interaction between Zedoary and Selexipag. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Zedoary and Selexipag at the same time of day?
At least one FDA label for a product containing Selexipag says to take it with food. If you take Zedoary on an empty stomach out of habit, keep them separate and take Selexipag with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Selexipag products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Zedoary and Selexipag combination checked?
Interactions in our licensed database are recorded against drug classes. Selexipag is filed under 4 classifications, and Zedoary has documented interactions with 1 drug class — none of Selexipag's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Zedoary interact with any other medications?
Yes. Zedoary has 643 documented drug interactions in our database — Selexipag is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Selexipag interact with any supplements?
Yes. Selexipag has documented interactions with 291 supplements in our database — Zedoary is not one of them. The Selexipag interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Zedoary monograph Uses, safety profile, and every drug interaction in one place Selexipag drug information The full plain-English guide to this medication Selexipag supplement interactions Every supplement checked against Selexipag, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Selexipag and Zedoary?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.