Drug & supplement interaction

Job's Tears + Selexipag

Selexipag brand name: Uptravi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Job's Tears and Selexipag in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Selexipag states a food rule worth keeping to.

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Interaction report

Job's Tears and Selexipag

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Selexipag and Job's Tears in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Job's Tears safety at a glance

Job's Tears overall Use caution Generally safe as a cooked food, but concentrated supplement evidence is limited.
Pregnancy Avoid Traditionally avoided in pregnancy and human safety data are lacking.
Breastfeeding Use caution Not enough reliable data; use only ordinary food amounts and check with a clinician.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Selexipag and Job's Tears? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Selexipag

Interactions in our licensed database are recorded against drug classes, not just single drug names. Selexipag is filed under 4 classifications — including cytochrome p450 2c8 (cyp2c8) substrates, anticoagulant/antiplatelet drugs, antihypertensive drugs. Job's Tears has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), chlorzoxazone (parafon forte, paraflex) (moderate) and dextromethorphan (robitussin dm, others) (moderate) — and none of Selexipag’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Job's Tears Does Interact With Other Medications

Job's Tears has 128 moderate known drug interactions in our database — Selexipag isn’t one of them. If you take anything else, check it against the full list below.

Moderate 128 No known interaction 2,702 (incl. Selexipag)
Taking anything else?

Check Another of Your Medications Against Job's Tears

Covers the 2,830 medications we’ve checked against Job's Tears. Pick one to open its full report.

What to actually watch for

What Selexipag’s Own FDA Label Lists

This is not an interaction — none of it involves Job's Tears. These are the most notable effects listed in the ADVERSE REACTIONS section of Selexipag’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • A change in thyroid levels Worth acting on
  • Anemia Worth acting on
  • Pain in an arm or leg
  • Headache mentioned in 26.4% of FDA reports for Selexipag
  • Diarrhea mentioned in 20.3% of FDA reports for Selexipag
  • Flushing
  • Joint pain
  • Reduced appetite
  • Muscle pain
  • Nausea mentioned in 16.1% of FDA reports for Selexipag

Showing the 10 most notable of 13 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Selexipag. Read the label on DailyMed › Where a percentage is shown, it is the share of 25,258 voluntary FDA FAERS reports for Selexipag that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Job's Tears’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Job's Tears side to compare — that is a limit of the record, not a statement that Job's Tears has no side effects.

How to take them

Some Selexipag Products Have a Food Rule — Job's Tears Should Not Break It

At least one FDA label for a product containing Selexipag says to take it with food. If you take Job's Tears on an empty stomach out of habit, keep them separate — and take Selexipag with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Selexipag products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Tolerability may be improved when taken with food [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Selexipag — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Selexipag

This page covers Job's Tears only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Selexipag page lists 291 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Danshen (major) and Piracetam (major).

By severity: 6 major · 258 moderate · 27 minor.

From our pharmacist’s overview on the Selexipag page

“People take selexipag (Uptravi) for pulmonary arterial hypertension, dangerously high pressure in the arteries of the lungs, and that diagnosis raises the stakes on this list of 291 interacting supplements. I would treat it with real vigilance.”

Reviewed by 2 · Jul 18, 2026

Open the Selexipag interaction page

One more smart check

Taking Job's Tears as Part of a Dietary Supplement Product? Check It for Interactions

We hold 111 real supplement products containing Job's Tears, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Job's Tears. Even though Job's Tears itself has no known interaction with Selexipag, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Job's Tears and Selexipag Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Job's Tears
Steady interest

#1,073 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Selexipag
Top half

#1,125 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Job's Tears reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Job's Tears and Selexipag records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Job's Tears

What is Job's Tears?

  • Digestive support
  • Skin health and smoothness
  • Mild swelling or water retention
  • General nourishing food/tonic
  • Joint discomfort (traditional use)

Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia. While it is generally safe as a food and is being studied for possible effects on metabolism, inflammation, and immunity, strong human evidence for its health claims is limited. Talk with your pharmacist or doctor before using concentrated supplements, especially during pregnancy.

Coix lacryma-jobi · Poaceae · Seeds (grain/kernel), sometimes root · Whole grain, cooked food, tea, powder, capsules, flour

An interaction check asks whether these two react with each other — it does not ask whether Job's Tears is a good idea for someone in your situation. Here is what our Job's Tears record says about it on its own.

Job's Tears: dosing

There is no established standardized dose for Job's Tears as a supplement. As a food, it is simply cooked and eaten like other whole grains.For capsules, powders, or teas, follow the directions on the product label, since strengths vary widely between products.

From our Job's Tears monograph — the full record covers uses, side effects and every documented interaction.

Read the full Job's Tears monograph & all interactions
Medication

About Selexipag

What Is Selexipag Used For?

Brand name: Uptravi

Selexipag tablets are used to treat pulmonary arterial hypertension (PAH, WHO Group I) — a type of high blood pressure in the arteries of the lungs. The goal is to slow the disease from getting worse and to reduce the chances of being hospitalized because of PAH.

Uptravi (selexipag) tablets are approved for both adults and children aged 2 years and older. Uptravi for injection (intravenous) is also available for adult patients who are already on Uptravi tablets but temporarily cannot take medicine by mouth.

Most-Reported Side Effects for Selexipag

From FAERS, the FDA’s public side-effect reporting system (25,685 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 6,740 reports
Diarrhea 5,173 reports
Dyspnea 4,774 reports
Nausea 4,103 reports
Fatigue 2,601 reports
See full Selexipag drug information
Keep checking

Other Drugs & Job's Tears

Browse every other medication we’ve checked against Job's Tears — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
128Moderate
0Minor
2,701No known interaction
128 Moderate 2,701 No interaction
Moderate

128 interactions

Showing 60 of 128 moderate interactions — see all 128 on the Job's Tears page.

No interaction 2,701 drugs checked — show the list

We also checked Job's Tears against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,701 medications checked with no known interaction — see the full Job's Tears list.

See the full Job's Tears interactions page
See every supplement checked against Selexipag, ranked by severity
Evidence & sources

Job's Tears References

The 3 references that drive our Job's Tears monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chiang W, Cheng C, Chiang M, Chung KT. Effects of dehulled adlay on the culture count of some microbiota and their metabolism in the gastrointestinal tract of rats. J Agric Food Chem 2000;48:829-32. PubMed
  2. Yu YM, Chang WC, Liu CS, Tsai CM. Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers. Biol Pharm Bull 2004;27:802-5. PubMed
  3. Yao HT, Lin JH, Liu YT, Li ML, Chiang W. Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients 2019;11(10):2473. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Job's Tears and Selexipag Together: Common Questions

Is it safe to take Job's Tears with Selexipag?
We do not list a known interaction between Job's Tears and Selexipag. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Job's Tears and Selexipag at the same time of day?
At least one FDA label for a product containing Selexipag says to take it with food. If you take Job's Tears on an empty stomach out of habit, keep them separate and take Selexipag with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Selexipag products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Job's Tears and Selexipag combination checked?
Interactions in our licensed database are recorded against drug classes. Selexipag is filed under 4 classifications, and Job's Tears has documented interactions with 5 drug classes — none of Selexipag's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Job's Tears interact with any other medications?
Yes. Job's Tears has 128 documented drug interactions in our database — Selexipag is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Selexipag interact with any supplements?
Yes. Selexipag has documented interactions with 291 supplements in our database — Job's Tears is not one of them. The Selexipag interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Job's Tears monograph Uses, safety profile, and every drug interaction in one place Selexipag drug information The full plain-English guide to this medication Selexipag supplement interactions Every supplement checked against Selexipag, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Selexipag and Job's Tears?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.