Medication interaction hub

What Supplements Interact with Treprostinil (Oral)?

Treprostinil (Oral) brand names: Remodulin, Orenitram. Every interaction below applies to the brands too.

291 Interactions 6 Major 258 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Treprostinil (Oral)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Treprostinil (Oral) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

With treprostinil (Orenitram), a medicine that opens narrowed lung arteries in pulmonary arterial hypertension, supplements deserve more scrutiny than usual. The drug widens blood vessels and dampens platelet clumping, and nearly everything on this list leans on one of those two levers. Over two hundred ingredients could add to bleeding risk, and more than a hundred can drag blood pressure too low or, like tyramine, work against the drug. Activated charcoal is a standout because it can soak up an oral dose before it ever gets absorbed.

Everyday items belong on your radar too. Fish oil can quietly add to the blood pressure lowering effect, and a smaller group can change how the tablet is absorbed, so space other oral products well apart from your dose. Read the six major-rated entries first; among 291 ingredients here, 258 rate moderate and 27 minor, but the majors carry the real danger.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 258 Minor 27 No known interaction 1,161

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Treprostinil (Oral): Top Interactions at a Glance

The Treprostinil (Oral) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 291 interacting ingredients — plus 1,161 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Treprostinil (Oral) Combinations Today

The Treprostinil (Oral) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Magnesium + Treprostinil (Oral)i

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full interaction Moderate Likelihood Possible Bupleurum + Treprostinil (Oral)i

Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Jiaogulan + Treprostinil (Oral)i

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Treprostinil (Oral)i

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Canadian Fleabane + Treprostinil (Oral)i

Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Octopamine + Treprostinil (Oral)i

In humans, octopamine 450-600 mg daily increases blood pressure in hypotensive patients.

Read the full interaction
The complete list

Every Supplement Checked Against Treprostinil (Oral)

All 1,452 ingredients in our database, ranked by severity — 291 with a Treprostinil (Oral) interaction on file and 1,161 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Treprostinil (Oral)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Magnesium with Treprostinil (Oral)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Full Magnesium + Treprostinil (Oral) answer

Can you take Bupleurum with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Bupleurum + Treprostinil (Oral) answer

Can you take Jiaogulan with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Jiaogulan + Treprostinil (Oral) answer

Can you take Coenzyme Q10 with Treprostinil (Oral)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Treprostinil (Oral) answer

Can you take Canadian Fleabane with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.

Full Canadian Fleabane + Treprostinil (Oral) answer

Can you take Vitamin E with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Vitamin E + Treprostinil (Oral) answer

Can you take Wasabi with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Wasabi + Treprostinil (Oral) answer

Can you take White Horehound with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that taking white horehound extract lowers blood pressure.

Full White Horehound + Treprostinil (Oral) answer

Can you take White Pepper with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits platelet aggregation.

Full White Pepper + Treprostinil (Oral) answer

Can you take Yerba Mate with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Yerba Mate + Treprostinil (Oral) answer

Can you take Arnica with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Full Arnica + Treprostinil (Oral) answer

Can you take Blue-green Algae with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.

Full Blue-green Algae + Treprostinil (Oral) answer

Can you take Chinese Prickly Ash with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Chinese prickly ash might inhibit platelet aggregation.

Full Chinese Prickly Ash + Treprostinil (Oral) answer

Can you take Coffee with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coffee may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Coffee + Treprostinil (Oral) answer

Can you take Cola Nut with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cola nut may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cola Nut + Treprostinil (Oral) answer

Can you take Fenugreek with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.

Full Fenugreek + Treprostinil (Oral) answer

Can you take Forsythia with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking forsythia with anticoagulant or antiplatelet drugs might increase the risk of bleeding due to decreased platelet aggre...

Full Forsythia + Treprostinil (Oral) answer

Can you take Green Coffee with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green coffee may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Green Coffee + Treprostinil (Oral) answer

Can you take Green Tea with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Green Tea + Treprostinil (Oral) answer

Can you take Ilex Guayusa with Treprostinil (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Ilex guayusa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Ilex Guayusa + Treprostinil (Oral) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Treprostinil (Oral) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Treprostinil (Oral), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Treprostinil (Oral) sits in 5 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Treprostinil (Oral) through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Treprostinil (Oral) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Treprostinil (Oral) through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Treprostinil (Oral) through this category.

Vasodilators 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Treprostinil (Oral) through this category.

About Treprostinil (Oral)

Treprostinil is a prostacyclin-based medicine used to treat pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD), available in inhaled, oral, and injectable forms.

Generic name: Treprostinil (Oral)  ·  Brand names: Remodulin, Orenitram.

See the full Treprostinil drug information

Related: does Treprostinil (Oral) deplete any nutrients?

Treprostinil (Oral) has 2 reported nutrient associations in the research literature — see the Treprostinil (Oral) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Treprostinil (Oral)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Treprostinil (Oral).

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Pharmacist Counseling Corner

Treprostinil (Oral) & Supplements: Common Questions

What supplements interact with Treprostinil (Oral)?
More than you might expect — 291 in total, though they are far from equal: 6 are rated major, 258 moderate, and 27 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Treprostinil (Oral) supplement interactions are the most serious?
The 6 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Danshen — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Treprostinil (Oral)?
Usually yes — most people on Treprostinil (Oral) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Remodulin have the same supplement interactions as Treprostinil (Oral)?
Yes — Remodulin, Orenitram all contain Treprostinil (Oral), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Treprostinil (Oral) deplete any vitamins or nutrients?
It might — Treprostinil (Oral) has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Treprostinil (Oral) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Treprostinil (Oral) and my other medications?
This page covers Treprostinil (Oral) against supplements and herbal ingredients. Checking Treprostinil (Oral) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Treprostinil drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.