Drug & supplement interaction

Astaxanthin + Selexipag

Selexipag brand name: Uptravi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Astaxanthin and Selexipag in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Selexipag states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Astaxanthin and Selexipag

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Selexipag and Astaxanthin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Astaxanthin safety at a glance

Astaxanthin overall Use caution Generally well tolerated in studies, but long-term safety data are limited.
Pregnancy Avoid Not enough safety data, so it is best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety data, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Selexipag and Astaxanthin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Selexipag

Interactions in our licensed database are recorded against drug classes, not just single drug names. Selexipag is filed under 4 classifications — including cytochrome p450 2c8 (cyp2c8) substrates, anticoagulant/antiplatelet drugs, antihypertensive drugs. Astaxanthin has documented interactions with 2 drug classes — the most serious being cytochrome p450 2b6 (cyp2b6) substrates (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Selexipag’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Astaxanthin Does Interact With Other Medications

Astaxanthin has 671 moderate known drug interactions in our database — Selexipag isn’t one of them. If you take anything else, check it against the full list below.

Moderate 671 No known interaction 2,159 (incl. Selexipag)
Taking anything else?

Check Another of Your Medications Against Astaxanthin

Covers the 2,830 medications we’ve checked against Astaxanthin. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Astaxanthin and Selexipag May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Stomach pain reported in 20.3% of FDA reports for Selexipag Additional detail

    Astaxanthin

    “Orally, astaxanthin 6 mg daily has caused two cases of increased bowel movements and two cases of red fecal color. A higher dose of astaxanthin (AstaCarox, AstaReal AB) 40 mg daily has caused severe stomach/abdominal pain in two patients.”

    Astaxanthin · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    2 sources cited
    1. 91736. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed
    2. 19165. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled

    Selexipag

    Listed in the ADVERSE REACTIONS section of the FDA label for Selexipag, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Selexipag come from the ADVERSE REACTIONS section of its FDA label; effects for Astaxanthin come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 25,258 voluntary FDA FAERS reports for Selexipag that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Selexipag Products Have a Food Rule — Astaxanthin Should Not Break It

At least one FDA label for a product containing Selexipag says to take it with food. If you take Astaxanthin on an empty stomach out of habit, keep them separate — and take Selexipag with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Selexipag products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Tolerability may be improved when taken with food [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Selexipag — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Selexipag Is Prescribed For, and What Astaxanthin Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Selexipag is a prescription medicine with approved uses on its FDA label. Astaxanthin is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Selexipag is prescribed for: Selexipag tablets are used to treat pulmonary arterial hypertension (PAH, WHO Group I) — a type of high blood pressure in the arteries of the lungs. The goal is to slow the disease from getting worse and to reduce the chances of being hospitalized because of PAH. Uptravi (selexipag) tablets are approved for both adults and children aged 2 years and older. Uptravi for injection (intravenous) is also available for adult patients who are already on Uptravi tablets but temporarily cannot take medicine by mouth.

Astaxanthin has been studied for:

  • Hypertension studied, not established Astaxanthin has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Astaxanthin for hypertension

    It is unclear if oral astaxanthin reduces blood pressure.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Selexipag on your own; if you are taking Astaxanthin for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Astaxanthin or Selexipag

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Astaxanthin or Selexipag, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Selexipag

This page covers Astaxanthin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Selexipag page lists 291 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Danshen (major) and Piracetam (major).

By severity: 6 major · 258 moderate · 27 minor.

From our pharmacist’s overview on the Selexipag page

“People take selexipag (Uptravi) for pulmonary arterial hypertension, dangerously high pressure in the arteries of the lungs, and that diagnosis raises the stakes on this list of 291 interacting supplements. I would treat it with real vigilance.”

Reviewed by 2 · Jul 18, 2026

Open the Selexipag interaction page

One more smart check

Taking Astaxanthin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,223 real supplement products containing Astaxanthin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Astaxanthin. Even though Astaxanthin itself has no known interaction with Selexipag, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Astaxanthin and Selexipag Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Astaxanthin
Top 10%

#114 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Selexipag
Steady interest

#2,106 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Astaxanthin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Astaxanthin and Selexipag records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Astaxanthin

What is Astaxanthin?

Astaxanthin
  • Antioxidant support
  • Skin health and aging
  • Eye health
  • Exercise recovery
  • Heart and inflammation support

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promising for a few uses, but the overall evidence is still limited and not strong enough to make firm claims. It appears generally well tolerated at typical supplement doses, but talk with your pharmacist or doctor before starting it.

Pigment extracted from microalgae (mainly Haematococcus pluvialis), yeast, and some seafood · Capsules, soft gels, tablets, and as an ingredient in some skin creams

An interaction check asks whether these two react with each other — it does not ask whether Astaxanthin is a good idea for someone in your situation. Here is what our Astaxanthin record says about it on its own.

Astaxanthin: dosing

There is no official standardized dose for astaxanthin, and amounts used in studies have varied. Because of this, the best approach is to follow the directions on the product label.Astaxanthin is fat-soluble, so it is often taken with a meal that contains some fat to help absorption.

From our Astaxanthin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Astaxanthin monograph & all interactions
Medication

About Selexipag

What Is Selexipag Used For?

Brand name: Uptravi

Selexipag tablets are used to treat pulmonary arterial hypertension (PAH, WHO Group I) — a type of high blood pressure in the arteries of the lungs. The goal is to slow the disease from getting worse and to reduce the chances of being hospitalized because of PAH.

Uptravi (selexipag) tablets are approved for both adults and children aged 2 years and older. Uptravi for injection (intravenous) is also available for adult patients who are already on Uptravi tablets but temporarily cannot take medicine by mouth.

Most-Reported Side Effects for Selexipag

From FAERS, the FDA’s public side-effect reporting system (25,685 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 6,740 reports
Diarrhea 5,173 reports
Dyspnea 4,774 reports
Nausea 4,103 reports
Fatigue 2,601 reports
See full Selexipag drug information
Keep checking

Other Drugs & Astaxanthin

Browse every other medication we’ve checked against Astaxanthin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
671Moderate
0Minor
2,158No known interaction
671 Moderate 2,158 No interaction
Moderate

671 interactions

Showing 60 of 671 moderate interactions — see all 671 on the Astaxanthin page.

No interaction 2,158 drugs checked — show the list

We also checked Astaxanthin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,158 medications checked with no known interaction — see the full Astaxanthin list.

See the full Astaxanthin interactions page
See every supplement checked against Selexipag, ranked by severity
Evidence & sources

Astaxanthin References

The 3 references that drive our Astaxanthin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Astaxanthin and Selexipag Together: Common Questions

Is it safe to take Astaxanthin with Selexipag?
We do not list a known interaction between Astaxanthin and Selexipag. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Astaxanthin and Selexipag have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Astaxanthin and Selexipag at the same time of day?
At least one FDA label for a product containing Selexipag says to take it with food. If you take Astaxanthin on an empty stomach out of habit, keep them separate and take Selexipag with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Selexipag products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Astaxanthin and Selexipag used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Astaxanthin in each. That is a conversation for your prescriber, especially if Selexipag is being adjusted to a target.
How was the Astaxanthin and Selexipag combination checked?
Interactions in our licensed database are recorded against drug classes. Selexipag is filed under 4 classifications, and Astaxanthin has documented interactions with 2 drug classes — none of Selexipag's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Astaxanthin interact with any other medications?
Yes. Astaxanthin has 671 documented drug interactions in our database — Selexipag is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Selexipag interact with any supplements?
Yes. Selexipag has documented interactions with 291 supplements in our database — Astaxanthin is not one of them. The Selexipag interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Astaxanthin monograph Uses, safety profile, and every drug interaction in one place Selexipag drug information The full plain-English guide to this medication Selexipag supplement interactions Every supplement checked against Selexipag, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Selexipag and Astaxanthin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.