Sorrel - Allegra D (Fexofenadine, Pseudoephedrine) Interaction
Herbal: Sorrel
Also Known As: Rumex acetosa, Acedera, Azeda-Brava, Common Sorrel, Field Sorrel, Garden Sorrel, Oseille, Oseille Commune, Petite Oseille, Red Sorrel, Sheep Sorrel, Sheep's Sorrel, Sorrel Dock, Sour Dock, Surette, Wiesensauerampfer
Drug: Fexofenadine, Pseudoephedrine
Brand names:
Allegra D
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Fexofenadine, Pseudoephedrine is classified as belonging to the following category: Organic Anion-Transporting Polypeptide Substrates (Oatp)
Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547.
Interaction Details
Fexofenadine, Pseudoephedrine is classified as belonging to the following category: Fexofenadine (Allegra)
Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).
Interaction Rating
Likelihood of Occurrence
LikelyWell-controlled human studies have demonstrated the likely existence of this interaction
References
- Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547.
Sorrel Overview
Sorrel is a perennial herb that is known for its distinct sour taste. It grows in temperate climates all over the world, and is often used in cooking to add a tangy flavor to dishes. The sour flavor of sorrel is due to the presence of oxalate, a compound found in many plants. In addition to its culinary uses, sorrel has also been used in traditional medicine for a variety of purposes, such as treating fever, inflammation, and skin conditions. Sorrel has been utilized for its potential health benefits, which may include antioxidant, anti-inflammatory, and antimicrobial properties. It is worth noting, however, that sorrel should be used in moderation, as the high levels of oxalate it contains can lead to the formation of kidney stones in some people.
Sorrel - More Interactions
Sorrel interacts with 167 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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