Medication interaction hub

What Supplements Interact with Fexofenadine, Pseudoephedrine?

Fexofenadine, Pseudoephedrine brand name: Allegra D. Every interaction below applies to the brands too.

188 Interactions 9 Major 140 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 20, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fexofenadine, Pseudoephedrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fexofenadine, Pseudoephedrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The person reaching for Allegra D (fexofenadine with pseudoephedrine) is congested, itchy, and probably washing the tablet down with juice or coffee, which is exactly where the trouble starts. This combination deserves genuine care. Nine of the 188 ingredients on file carry a major rating, and everyday items lead that group. Apple and sweet orange juice block the gut transporter fexofenadine needs, cutting how much reaches your blood, while grapefruit works the opposite way, slowing the breakdown of many compounds and pushing levels up.

The pseudoephedrine half is itself a stimulant, and 44 of these ingredients, everyday caffeine sources included, can stack jitteriness, higher blood pressure, and heart strain on top of it. Most of the rest, 140 moderate and 39 minor in all, act more quietly by changing how the drug is absorbed or cleared. Take the tablet with water, not juice, and keep those drinks several hours from your dose.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 140 Minor 39 No known interaction 1,264

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Fexofenadine, Pseudoephedrine: Top Interactions at a Glance

The Fexofenadine, Pseudoephedrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 188 interacting ingredients — plus 1,264 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Fexofenadine, Pseudoephedrine Combinations Today

The Fexofenadine, Pseudoephedrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Sweet Orange + Fexofenadine, Pseudoephedrinei

Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Read the full interaction Major Likelihood Likely Apple + Fexofenadine, Pseudoephedrinei

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Read the full interaction Moderate Likelihood Probable Cola Nut + Fexofenadine, Pseudoephedrinei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Higenamine + Fexofenadine, Pseudoephedrinei

Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Grapefruit + Fexofenadine, Pseudoephedrinei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Fexofenadine, Pseudoephedrinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Fexofenadine, Pseudoephedrine

All 1,452 ingredients in our database, ranked by severity — 188 with a Fexofenadine, Pseudoephedrine interaction on file and 1,264 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fexofenadine, Pseudoephedrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Sweet Orange with Fexofenadine, Pseudoephedrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Full Sweet Orange + Fexofenadine, Pseudoephedrine answer

Can you take Apple with Fexofenadine, Pseudoephedrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Full Apple + Fexofenadine, Pseudoephedrine answer

Can you take Cola Nut with Fexofenadine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cola Nut + Fexofenadine, Pseudoephedrine answer

Can you take Higenamine with Fexofenadine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Fexofenadine, Pseudoephedrine answer

Can you take Zedoary with Fexofenadine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Fexofenadine, Pseudoephedrine answer

Can you take Thyroid Extract with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Fexofenadine, Pseudoephedrine answer

Can you take Aegeline with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Fexofenadine, Pseudoephedrine answer

Can you take Agar with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Fexofenadine, Pseudoephedrine answer

Can you take Algin with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Fexofenadine, Pseudoephedrine answer

Can you take Ashwagandha with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Fexofenadine, Pseudoephedrine answer

Can you take Atractylodes with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might increase the levels of CYP3A4 substrates.

Full Atractylodes + Fexofenadine, Pseudoephedrine answer

Can you take Bael with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael and its constituents marmelosin and marmesinin inhibited cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Bael + Fexofenadine, Pseudoephedrine answer

Can you take Baikal Skullcap with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.

Full Baikal Skullcap + Fexofenadine, Pseudoephedrine answer

Can you take Black Cohosh with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.

Full Black Cohosh + Fexofenadine, Pseudoephedrine answer

Can you take Black Psyllium with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Fexofenadine, Pseudoephedrine answer

Can you take Blond Psyllium with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Fexofenadine, Pseudoephedrine answer

Can you take Breadfruit with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more i...

Full Breadfruit + Fexofenadine, Pseudoephedrine answer

Can you take Carob with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Fexofenadine, Pseudoephedrine answer

Can you take Cascara Sagrada with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.

Full Cascara Sagrada + Fexofenadine, Pseudoephedrine answer

Can you take Fucus Vesiculosus with Fexofenadine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Fexofenadine, Pseudoephedrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fexofenadine, Pseudoephedrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fexofenadine, Pseudoephedrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fexofenadine, Pseudoephedrine sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Fexofenadine, Pseudoephedrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Fexofenadine, Pseudoephedrine through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Fexofenadine, Pseudoephedrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fexofenadine, Pseudoephedrine through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fexofenadine, Pseudoephedrine through this category.

Fexofenadine (Allegra) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Fexofenadine, Pseudoephedrine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Fexofenadine, Pseudoephedrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Fexofenadine, Pseudoephedrine through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Fexofenadine, Pseudoephedrine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fexofenadine, Pseudoephedrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fexofenadine, Pseudoephedrine.

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Pharmacist Counseling Corner

Fexofenadine, Pseudoephedrine & Supplements: Common Questions

What supplements interact with Fexofenadine, Pseudoephedrine?
In our interaction database, 188 supplement and herbal ingredients have an interaction with Fexofenadine, Pseudoephedrine on file — 9 rated major, 140 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Apple, Grapefruit, Sweet Orange.
Which Fexofenadine, Pseudoephedrine supplement interactions are the most serious?
The 9 major-rated combinations — led by Apple, Grapefruit, Sweet Orange, Activated Charcoal and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Fexofenadine, Pseudoephedrine?
That depends entirely on which supplement. The honest answer for Fexofenadine, Pseudoephedrine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Allegra D have the same supplement interactions as Fexofenadine, Pseudoephedrine?
Yes — Allegra D all contain Fexofenadine, Pseudoephedrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Fexofenadine, Pseudoephedrine and my other medications?
This page covers Fexofenadine, Pseudoephedrine against supplements and herbal ingredients. Checking Fexofenadine, Pseudoephedrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.