Drug & supplement interaction

Mullein + Fexofenadine, Pseudoephedrine

Fexofenadine, Pseudoephedrine brand name: Allegra D.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Mullein and Fexofenadine, Pseudoephedrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Fexofenadine, Pseudoephedrine states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Mullein and Fexofenadine, Pseudoephedrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fexofenadine, Pseudoephedrine and Mullein in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mullein safety at a glance

Mullein overall Use caution Generally well tolerated for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough data to consider it safe while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fexofenadine, Pseudoephedrine and Mullein? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fexofenadine, Pseudoephedrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fexofenadine, Pseudoephedrine is filed under 9 classifications — including organic anion-transporting polypeptide substrates (oatp), alpha-adrenergic agonists, stimulant drugs. Mullein has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (minor) — and none of Fexofenadine, Pseudoephedrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Mullein Does Interact With Other Medications

Mullein has 122 minor known drug interactions in our database — Fexofenadine, Pseudoephedrine isn’t one of them. If you take anything else, check it against the full list below.

Minor 122 No known interaction 2,708 (incl. Fexofenadine, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against Mullein

Covers the 2,830 medications we’ve checked against Mullein. Pick one to open its full report.

What to actually watch for

What Mullein Itself Has Been Linked To

This is not an interaction — nothing below involves Fexofenadine, Pseudoephedrine. It is the side-effect record for Mullein on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Mullein, this list is the first place to look.

  • A skin rash Additional detail

    “Two case reports have described dermatitis, with positive patch tests, after topical exposure to the whole plant, or by occupational inhalation of plant dust. In the case of topical exposure, the patient also had positive patch tests to other plants.”

    Mullein · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 92839. Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
    2. 97316. Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.

Everything above comes from the Natural Medicines adverse-effect record for Mullein — expand a row for the licensed statement it rests on. We haven’t matched Fexofenadine, Pseudoephedrine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Fexofenadine, Pseudoephedrine.

How to take them

Some Fexofenadine, Pseudoephedrine Products Have a Food Rule — Mullein Should Not Break It

At least one FDA label for a product containing Fexofenadine, Pseudoephedrine says to take it on an empty stomach. Most supplements — Mullein included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Fexofenadine, Pseudoephedrine on its own and move Mullein to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Fexofenadine, Pseudoephedrine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Directions do not divide, crush, chew or dissolve the tablet; swallow tablet whole adults and children 12 years of age and over take 1 tablet with a glass of water every 24 hours on an empty stomach; do not take more than 1 tablet in 24 hours children under 12 years of age do not use adults 65 years of age and older ask a doctor consumers with kidney disease ask a doctor

From the Dosage and Administration section of the FDA label we read for Fexofenadine, Pseudoephedrine — where that label names a specific product, the instruction is that product's.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Mullein or Fexofenadine, Pseudoephedrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Mullein or Fexofenadine, Pseudoephedrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fexofenadine, Pseudoephedrine

This page covers Mullein only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fexofenadine, Pseudoephedrine page lists 188 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Ephedra (major), Grapefruit (major) and Peyote (major).

By severity: 9 major · 140 moderate · 39 minor.

From our pharmacist’s overview on the Fexofenadine, Pseudoephedrine page

“The person reaching for Allegra D (fexofenadine with pseudoephedrine) is congested, itchy, and probably washing the tablet down with juice or coffee, which is exactly where the trouble starts. This combination deserves genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Fexofenadine, Pseudoephedrine interaction page

One more smart check

Taking Mullein as Part of a Dietary Supplement Product? Check It for Interactions

We hold 780 real supplement products containing Mullein, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mullein. Even though Mullein itself has no known interaction with Fexofenadine, Pseudoephedrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mullein and Fexofenadine, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mullein
Top 25%

#182 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fexofenadine, Pseudoephedrine
Top half

#1,148 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mullein reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Mullein and Fexofenadine, Pseudoephedrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mullein

What is Mullein?

Mullein
  • Cough and chest congestion
  • Sore throat
  • Bronchitis and respiratory irritation
  • Earache (traditional ear oil)
  • Mild inflammation

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits are not well proven, but it is generally considered low-risk for short-term use in healthy adults. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a medical condition.

Verbascum thapsus · Scrophulariaceae · Leaves and flowers (sometimes roots) · Tea (infusion), tincture, capsules, syrups, lozenges, and ear oil drops

An interaction check asks whether these two react with each other — it does not ask whether Mullein is a good idea for someone in your situation. Here is what our Mullein record says about it on its own.

Mullein: dosing

There is no official or standardized dose for mullein. The amount used varies widely between products and traditional recipes, such as teas, tinctures, capsules, and syrups.The safest approach is to follow the directions on the product label and not exceed the recommended amount. A well-made tea is typically prepared by steeping the dried leaves or flowers in hot water and straining well to remove the irritating plant hairs.

From our Mullein monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mullein monograph & all interactions
Keep checking

Other Drugs & Mullein

Browse every other medication we’ve checked against Mullein — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
122Minor
2,707No known interaction
122 Minor 2,707 No interaction
Minor

122 interactions

Showing 60 of 122 minor interactions — see all 122 on the Mullein page.

No interaction 2,707 drugs checked — show the list

We also checked Mullein against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Mullein list.

See the full Mullein interactions page
See every supplement checked against Fexofenadine, Pseudoephedrine, ranked by severity
Evidence & sources

Mullein References

The 2 references that drive our Mullein monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
  2. Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mullein and Fexofenadine, Pseudoephedrine Together: Common Questions

Is it safe to take Mullein with Fexofenadine, Pseudoephedrine?
We do not list a known interaction between Mullein and Fexofenadine, Pseudoephedrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Mullein and Fexofenadine, Pseudoephedrine at the same time of day?
At least one FDA label for a product containing Fexofenadine, Pseudoephedrine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Fexofenadine, Pseudoephedrine on its own and move Mullein to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Mullein and Fexofenadine, Pseudoephedrine combination checked?
Interactions in our licensed database are recorded against drug classes. Fexofenadine, Pseudoephedrine is filed under 9 classifications, and Mullein has documented interactions with 1 drug class — none of Fexofenadine, Pseudoephedrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Mullein interact with any other medications?
Yes. Mullein has 122 documented drug interactions in our database — Fexofenadine, Pseudoephedrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fexofenadine, Pseudoephedrine interact with any supplements?
Yes. Fexofenadine, Pseudoephedrine has documented interactions with 188 supplements in our database — Mullein is not one of them. The Fexofenadine, Pseudoephedrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mullein monograph Uses, safety profile, and every drug interaction in one place Fexofenadine, Pseudoephedrine supplement interactions Every supplement checked against Fexofenadine, Pseudoephedrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fexofenadine, Pseudoephedrine and Mullein?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.