Drug & supplement interaction

Stereospermum + Ruxolitinib

Ruxolitinib brand names: Jakafi, Opzelura.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Stereospermum and Ruxolitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Stereospermum and Ruxolitinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ruxolitinib and Stereospermum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stereospermum safety at a glance

Stereospermum overall Not established Human safety data are very limited, so its overall safety is not well established.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data for breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ruxolitinib and Stereospermum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ruxolitinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ruxolitinib is filed under 3 classifications — topical drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Stereospermum has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Ruxolitinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Stereospermum Does Interact With Other Medications

Stereospermum has 86 moderate known drug interactions in our database — Ruxolitinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Ruxolitinib)
Taking anything else?

Check Another of Your Medications Against Stereospermum

Covers the 2,830 medications we’ve checked against Stereospermum. Pick one to open its full report.

What to actually watch for

What Ruxolitinib’s Own FDA Label Lists

This is not an interaction — none of it involves Stereospermum. These are the most notable effects listed in the ADVERSE REACTIONS section of Ruxolitinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Unsteadiness Worth acting on
  • Low blood sugar Worth acting on
  • Blood clots Worth acting on
  • Anemia Worth acting on mentioned in 8.6% of FDA reports for Ruxolitinib
  • A severe skin reaction Worth acting on
  • A low platelet count Worth acting on mentioned in 3.9% of FDA reports for Ruxolitinib
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on

Showing the 10 most notable of 24 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ruxolitinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 69,262 voluntary FDA FAERS reports for Ruxolitinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Stereospermum’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Stereospermum side to compare — that is a limit of the record, not a statement that Stereospermum has no side effects.

Everything else you take

See Every Supplement That Interacts With Ruxolitinib

This page covers Stereospermum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ruxolitinib page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 42 minor.

From our pharmacist’s overview on the Ruxolitinib page

“Ruxolitinib (Jakafi for myelofibrosis and other blood cancers, Opzelura as a skin cream) is cleared by one liver enzyme, CYP3A4, and that single fact explains nearly all 141 supplements here, which is why this list deserves real caution. Three entries are rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Ruxolitinib interaction page

One more smart check

Taking Stereospermum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 34 real supplement products containing Stereospermum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Stereospermum. Even though Stereospermum itself has no known interaction with Ruxolitinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Stereospermum and Ruxolitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stereospermum
Steady interest

#974 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ruxolitinib
Steady interest

#1,822 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stereospermum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Stereospermum and Ruxolitinib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stereospermum

What is Stereospermum?

  • Fever
  • Inflammation and pain
  • Digestive complaints
  • Respiratory issues
  • General tonic in Ayurveda

Stereospermum is a tree used in traditional Ayurvedic medicine, most notably as one of the herbs in the classic 'Dashamula' (ten-root) formula. There is very little high-quality human research to confirm its benefits, so its uses remain largely traditional. If you are considering it, talk with a pharmacist or doctor first, especially if you are pregnant, breastfeeding, or taking other medicines.

Stereospermum suaveolens · Bignoniaceae · Root bark, stem bark, leaves, and flowers · Powder (churna), decoction, capsules, and as part of traditional Ayurvedic herbal blends

An interaction check asks whether these two react with each other — it does not ask whether Stereospermum is a good idea for someone in your situation. Here is what our Stereospermum record says about it on its own.

Stereospermum: dosing

There is no well-established standardized dose for Stereospermum. Traditional preparations vary, and it is often used as part of multi-herb formulas rather than alone.If you choose to use a product that contains it, follow the directions on the product label and do not exceed the recommended amount.

From our Stereospermum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stereospermum monograph & all interactions
Medication

About Ruxolitinib

What Is Ruxolitinib Used For?

Brand names: Jakafi, Opzelura

Ruxolitinib is approved to treat several serious blood and immune conditions in adults, and some in patients as young as 12. It is used for myelofibrosis (a bone marrow disorder that disrupts normal blood cell production), polycythemia vera (a condition where the bone marrow makes too many red blood cells), and two forms of graft-versus-host disease (GVHD) — a complication that can occur after a stem cell transplant.

For polycythemia vera, it is specifically for patients who have not responded well to, or cannot tolerate, a medication called hydroxyurea. For chronic GVHD, it is used after at least one or two other treatments have failed.

Most-Reported Side Effects for Ruxolitinib

From FAERS, the FDA’s public side-effect reporting system (71,241 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 6,114 reports
Anemia 3,094 reports
Haemoglobin decreased 2,961 reports
Platelet count decreased 2,700 reports
Diarrhea 2,683 reports
See full Ruxolitinib drug information
Keep checking

Other Drugs & Stereospermum

Browse every other medication we’ve checked against Stereospermum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Stereospermum page.

No interaction 2,743 drugs checked — show the list

We also checked Stereospermum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Stereospermum list.

See the full Stereospermum interactions page
See every supplement checked against Ruxolitinib, ranked by severity
Evidence & sources

Stereospermum References

The 2 references that drive our Stereospermum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Balasubramanian T, Lal MS, Sarkar M, Chatterjee TK. Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin-induced diabetic rats. J Diet Suppl 2009;6(3):227-51.
  2. Balsubramanian T, Senthilkumar GP, Karthikeyan M, Chatterjee TK. Protective effect of ethyl acetate fraction of Stereospermum suaveolens against hepatic oxidative stress in STZ diabetic rats. J Tradit Complement Med 2013;3(3):175-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stereospermum and Ruxolitinib Together: Common Questions

Is it safe to take Stereospermum with Ruxolitinib?
We do not list a known interaction between Stereospermum and Ruxolitinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Stereospermum and Ruxolitinib combination checked?
Interactions in our licensed database are recorded against drug classes. Ruxolitinib is filed under 3 classifications, and Stereospermum has documented interactions with 1 drug class — none of Ruxolitinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Stereospermum interact with any other medications?
Yes. Stereospermum has 86 documented drug interactions in our database — Ruxolitinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ruxolitinib interact with any supplements?
Yes. Ruxolitinib has documented interactions with 141 supplements in our database — Stereospermum is not one of them. The Ruxolitinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stereospermum monograph Uses, safety profile, and every drug interaction in one place Ruxolitinib drug information The full plain-English guide to this medication Ruxolitinib supplement interactions Every supplement checked against Ruxolitinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ruxolitinib and Stereospermum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.