Drug & supplement interaction

Sunflower Oil + Roflumilast

Roflumilast brand names: Daliresp, Zoryve.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sunflower Oil and Roflumilast in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Sunflower Oil and Roflumilast

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Roflumilast and Sunflower Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sunflower Oil safety at a glance

Sunflower Oil overall Generally safe Sunflower oil is widely used as a food and is generally safe for most people in normal dietary amounts.
Pregnancy Likely Safe When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of sunflower oil wh... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of sunflower oil wh... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Roflumilast and Sunflower Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Roflumilast

Interactions in our licensed database are recorded against drug classes, not just single drug names. Roflumilast is filed under 3 classifications — topical drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Sunflower Oil has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Roflumilast’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sunflower Oil Does Interact With Other Medications

Sunflower Oil has 86 moderate known drug interactions in our database — Roflumilast isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Roflumilast)
Taking anything else?

Check Another of Your Medications Against Sunflower Oil

Covers the 2,830 medications we’ve checked against Sunflower Oil. Pick one to open its full report.

What to actually watch for

What Sunflower Oil Itself Has Been Linked To

This is not an interaction — nothing below involves Roflumilast. It is the side-effect record for Sunflower Oil on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Sunflower Oil, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    “Orally, sunflower oil can cause an allergic reaction in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs. However, the protein content of sunflower oil is very low. In one case report, an allergic response to sunflower oil did not occur despite presenting with severe allergy and anaphylaxis to sunflower seed.”

    Sunflower Oil · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 108140. An J. Anaphylaxis to sunflower seed with tolerance to sunflower oil: A case report. Medicina (Kaunas) 2021;57(7):661. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Sunflower Oil — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Roflumilast’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Roflumilast column appears here.

Special populations

Sunflower Oil in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of sunflower oil when used in amounts greater than those found in food.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Roflumilast Is Prescribed For, and What Sunflower Oil Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Roflumilast is a prescription medicine with approved uses on its FDA label. Sunflower Oil is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Roflumilast is prescribed for: Daliresp and roflumilast tablets are used to reduce the risk of COPD (chronic obstructive pulmonary disease) flare-ups in adults with severe COPD linked to chronic bronchitis who have had flare-ups in the past. They are not rescue inhalers and will not relieve a sudden breathing attack. Zoryve cream is used topically to treat plaque psoriasis (adults and children 2+) and mild to moderate atopic dermatitis (eczema) in adults and children as young as 2. Zoryve topical foam is used to treat seborrheic dermatitis (adults and children 9+) and plaque psoriasis of the scalp and body (adults and children 12+).

Sunflower Oil has been studied for:

  • Psoriasis studied, not established Sunflower Oil has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Sunflower Oil for psoriasis

    Although there is interest in using topical sunflower oil for psoriasis, there is insufficient reliable information about the clinical effects of sunflower oil for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Roflumilast on your own; if you are taking Sunflower Oil for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Roflumilast

This page covers Sunflower Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Roflumilast page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 42 minor.

From our pharmacist’s overview on the Roflumilast page

“Roflumilast (Daliresp for severe COPD, Zoryve as a cream for skin conditions) is cleared almost entirely by one liver enzyme, CYP3A4, which is why 121 of the 141 supplements on this page can push its level up or down, and why real caution is warranted here. Start with the three rated major: grapefruit blocks that enzyme and can raise r…”

Reviewed by 2 · Jul 18, 2026

Open the Roflumilast interaction page

One more smart check

Taking Sunflower Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 314 real supplement products containing Sunflower Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sunflower Oil. Even though Sunflower Oil itself has no known interaction with Roflumilast, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sunflower Oil and Roflumilast Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sunflower Oil
Top 25%

#331 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Roflumilast
Steady interest

#1,443 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sunflower Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sunflower Oil and Roflumilast records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sunflower Oil

What is Sunflower Oil?

  • Cooking and frying
  • Skin moisturizing
  • Hair and scalp care
  • Source of vitamin E and unsaturated fats
  • Massage and carrier oil
  • Heart-healthy fat substitute

Sunflower oil is a common edible vegetable oil rich in unsaturated fats and vitamin E that most people can use safely as part of a normal diet. As a food it is generally regarded as safe, and it is also used on the skin, but evidence for treating any specific medical condition is limited. If you have a known allergy to sunflower seeds or ragweed-family plants, use caution.

Helianthus annuus · Asteraceae · Oil pressed from the seeds · Cooking oil, topical oil, skin and hair products, soft-gel capsules, ingredient in salad dressings and margarine

An interaction check asks whether these two react with each other — it does not ask whether Sunflower Oil is a good idea for someone in your situation. Here is what our Sunflower Oil record says about it on its own.

Sunflower Oil: dosing

There is no standard medicinal dose of sunflower oil. As a food, it is simply used in cooking and baking like other vegetable oils, in the amounts called for in recipes.For skin or hair use, people typically apply a small amount as needed.

From our Sunflower Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sunflower Oil monograph & all interactions
Medication

About Roflumilast

What Is Roflumilast Used For?

Brand names: Daliresp, Zoryve

Daliresp and roflumilast tablets are used to reduce the risk of COPD (chronic obstructive pulmonary disease) flare-ups in adults with severe COPD linked to chronic bronchitis who have had flare-ups in the past. They are not rescue inhalers and will not relieve a sudden breathing attack.

Zoryve cream is used topically to treat plaque psoriasis (adults and children 2+) and mild to moderate atopic dermatitis (eczema) in adults and children as young as 2. Zoryve topical foam is used to treat seborrheic dermatitis (adults and children 9+) and plaque psoriasis of the scalp and body (adults and children 12+).

Most-Reported Side Effects for Roflumilast

From FAERS, the FDA’s public side-effect reporting system (6,927 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,054 reports
Chronic obstructive pulmonary disease 657 reports
Diarrhea 596 reports
Nausea 491 reports
Pneumonia 476 reports
See full Roflumilast drug information
Keep checking

Other Drugs & Sunflower Oil

Browse every other medication we’ve checked against Sunflower Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Sunflower Oil page.

No interaction 2,743 drugs checked — show the list

We also checked Sunflower Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Sunflower Oil list.

See the full Sunflower Oil interactions page
See every supplement checked against Roflumilast, ranked by severity
Evidence & sources

Sunflower Oil References

The 2 references that drive our Sunflower Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. An J. Anaphylaxis to sunflower seed with tolerance to sunflower oil: A case report. Medicina (Kaunas) 2021;57(7):661. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sunflower Oil and Roflumilast Together: Common Questions

Is it safe to take Sunflower Oil with Roflumilast?
We do not list a known interaction between Sunflower Oil and Roflumilast. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Sunflower Oil and Roflumilast used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Sunflower Oil in each. That is a conversation for your prescriber, especially if Roflumilast is being adjusted to a target.
How was the Sunflower Oil and Roflumilast combination checked?
Interactions in our licensed database are recorded against drug classes. Roflumilast is filed under 3 classifications, and Sunflower Oil has documented interactions with 1 drug class — none of Roflumilast's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sunflower Oil interact with any other medications?
Yes. Sunflower Oil has 86 documented drug interactions in our database — Roflumilast is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Roflumilast interact with any supplements?
Yes. Roflumilast has documented interactions with 141 supplements in our database — Sunflower Oil is not one of them. The Roflumilast interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sunflower Oil monograph Uses, safety profile, and every drug interaction in one place Roflumilast drug information The full plain-English guide to this medication Roflumilast supplement interactions Every supplement checked against Roflumilast, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Roflumilast and Sunflower Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.