Drug & supplement interaction

Terminalia Chebula + Glucagon

Glucagon brand names: Glucagon, Baqsimi.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Terminalia Chebula has a moderate interaction with Glucagon. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Terminalia Chebula and Glucagon

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Glucagon

Glucagon falls under ANTIDIABETES DRUGS — the group Terminalia Chebula interacts with.

Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal research suggests that Terminalia chebula fruit extract has hypoglycemic effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's a little twist with this pairing. Glucagon isn't a daily diabetes pill that lowers your blood sugar. It does the opposite. It's an emergency medicine that tells your liver to dump stored sugar into your blood to rescue you from a dangerous low. So while haritaki may gently lower blood sugar (based mostly on animal studies, not strong human data), the bigger concern is whether the supplement could blunt how well glucagon raises your sugar back up when you really need it.

This is theoretical, so don't panic. But since glucagon is used in true emergencies, it's worth mentioning haritaki to your pharmacist or doctor so they can keep an eye on your overall blood sugar control. Never change anything on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
  3. Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
  4. Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
  5. Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed
  6. Agrawal OD, Kulkarni YA. Treatment with Terminalia chebula extract reduces insulin resistance, hyperglycemia and improves SIRT1 expression in type 2 diabetic rats. Life (Basel) 2023;13(5):1168. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Terminalia Chebula Also Interacts With Other Medications

Terminalia Chebula has 92 moderate known drug interactions in our database — the Glucagon one above is one of them. If you take anything else, check it against the full list below.

Moderate 92 No known interaction 2,738 (incl. Glucagon)
Taking anything else?

Check Another of Your Medications Against Terminalia Chebula

Covers the 2,830 medications we’ve checked against Terminalia Chebula. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Glucagon

This page covers Terminalia Chebula only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glucagon page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Glucagon page

“If you keep glucagon (Baqsimi) on hand to rescue a severe low blood sugar, read this list with genuine care. Of the 256 supplements and herbs on file, 239 affect blood sugar control, most by lowering glucose further, which can set up the very crash glucagon exists to reverse.”

Reviewed by 2 · Jul 18, 2026

Open the Glucagon interaction page

How much people look this up

Where Terminalia Chebula and Glucagon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Terminalia Chebula
Steady interest

#1,001 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glucagon
Steady interest

#1,893 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Terminalia Chebula

What is Terminalia Chebula?

  • Digestive support and constipation
  • Antioxidant support
  • Oral and throat health
  • General immune support
  • Traditional tonic in Ayurvedic medicine

Terminalia chebula, often called haritaki, is a fruit widely used in Ayurvedic medicine, most commonly for digestion and as a key part of the Triphala blend. Early laboratory and small human studies suggest possible antioxidant and digestive effects, but high-quality evidence in people is limited. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or take other medicines.

Read the full Terminalia Chebula monograph & all interactions
Medication

About Glucagon Nasal Powder

What Is Glucagon Nasal Powder Used For?

Brand names: Glucagon, Baqsimi

Baqsimi nasal powder is used to treat severe hypoglycemia — dangerously low blood sugar — in adults and children aged 1 year and older who have diabetes. It is an emergency medicine meant to be used when a person cannot eat or drink to raise their blood sugar on their own.

See full Glucagon Nasal Powder drug information
Keep checking

Other Drugs & Terminalia Chebula

Browse every other medication we’ve checked against Terminalia Chebula — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
92Moderate
0Minor
2,737No known interaction
92 Moderate 2,737 No interaction
Moderate

92 interactions

Showing 60 of 92 moderate interactions — see all 92 on the Terminalia Chebula page.

No interaction 2,737 drugs checked — show the list

We also checked Terminalia Chebula against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,737 medications checked with no known interaction — see the full Terminalia Chebula list.

See the full Terminalia Chebula interactions page
See every supplement checked against Glucagon, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Terminalia Chebula monograph › Uses, safety, and every drug interaction in one place Glucagon supplement interactions › Every supplement checked against Glucagon, ranked by severity Glucagon Nasal Powder drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Terminalia Chebula and Glucagon Together: Common Questions

Can you take Terminalia Chebula with Glucagon?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Terminalia Chebula and Glucagon interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Glucagon and Terminalia Chebula?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.