Drug & supplement interaction

Tocotrienols + Raltegravir

Raltegravir brand name: Isentress.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tocotrienols and Raltegravir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Tocotrienols and Raltegravir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Raltegravir and Tocotrienols in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tocotrienols safety at a glance

Tocotrienols overall Use caution Generally well tolerated in studies, but long-term safety at supplement doses is not well established.
Pregnancy Avoid Not enough safety information, so it is best to avoid supplemental doses during pregnancy.
Breastfeeding Use caution Little is known about safety while breastfeeding, so avoid supplements unless advised by your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Raltegravir and Tocotrienols? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Raltegravir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Raltegravir is filed under 4 classifications — including integrase inhibitors, glucuronidated drugs, oral drugs. Tocotrienols has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (minor) — and none of Raltegravir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tocotrienols Does Interact With Other Medications

Tocotrienols has 122 minor known drug interactions in our database — Raltegravir isn’t one of them. If you take anything else, check it against the full list below.

Minor 122 No known interaction 2,708 (incl. Raltegravir)
Taking anything else?

Check Another of Your Medications Against Tocotrienols

Covers the 2,830 medications we’ve checked against Tocotrienols. Pick one to open its full report.

What to actually watch for

What Tocotrienols Itself Has Been Linked To

This is not an interaction — nothing below involves Raltegravir. It is the side-effect record for Tocotrienols on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Tocotrienols, this list is the first place to look.

  • Itching Additional detail

    “Topically, a cream containing 5% tocotrienols has been reported to cause mild itching in 7% of patients in one clinical study. Contact dermatitis has been reported in 33% of patients using a cream containing vitamin E as a mixture of tocopherols and tocotrienols. However, it is unclear if this effect resulted from tocopherols, tocotrienols, or the combination.”

    Tocotrienols · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 99699. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
    2. 4721. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  • A skin rash Additional detail

    Recorded for Tocotrienols in the same Natural Medicines adverse-effect record shown under Itching above.

Everything above comes from the Natural Medicines adverse-effect record for Tocotrienols — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Raltegravir’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Raltegravir column appears here.

Everything else you take

See Every Supplement That Interacts With Raltegravir

This page covers Tocotrienols only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Raltegravir page lists 33 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Breadfruit (moderate), Brussels Sprout (moderate), Cabbage (moderate) and Calcium (moderate).

By severity: 1 major · 22 moderate · 10 minor.

From our pharmacist’s overview on the Raltegravir page

“For someone taking raltegravir (Isentress) to keep HIV suppressed, a steady drug level is what blocks rebound and resistance, and this list deserves genuine vigilance. The lone major-rated entry is activated charcoal, which can soak up the medicine in the gut and cut what reaches your blood.”

Reviewed by 2 · Jul 18, 2026

Open the Raltegravir interaction page

One more smart check

Taking Tocotrienols as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Tocotrienols, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tocotrienols. Even though Tocotrienols itself has no known interaction with Raltegravir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tocotrienols and Raltegravir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tocotrienols
Top 25%

#337 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Raltegravir
Steady interest

#2,481 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tocotrienols reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tocotrienols and Raltegravir records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tocotrienols

What is Tocotrienols?

Tocotrienols
  • Heart and cholesterol support
  • Antioxidant support
  • Liver health (fatty liver)
  • Bone health
  • Brain and nerve protection

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusive, and a standard dose is not established. They are generally well tolerated, but talk with your pharmacist or doctor before using them, especially during pregnancy or if you take blood thinners.

Oil and extracts from plant seeds, bran, and fruits (such as rice bran, palm fruit, and annatto) · Softgel capsules, oil, combination vitamin E supplements

An interaction check asks whether these two react with each other — it does not ask whether Tocotrienols is a good idea for someone in your situation. Here is what our Tocotrienols record says about it on its own.

Tocotrienols: dosing

There is no official or standardized dose of tocotrienols. Amounts used in research have varied widely depending on the source and the condition being studied.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Tocotrienols monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tocotrienols monograph & all interactions
Medication

About Raltegravir

What Is Raltegravir Used For?

Brand name: Isentress

Raltegravir — available as Isentress and as the generic raltegravir tablet — is used to treat HIV-1 (human immunodeficiency virus) infection. It is always used together with other antiretroviral (anti-HIV) medicines, never on its own.

Isentress is approved for adults and for children weighing at least 2 kg. Raltegravir tablets are approved for adults and for children weighing at least 25 kg who can swallow a tablet whole.

Most-Reported Side Effects for Raltegravir

From FAERS, the FDA’s public side-effect reporting system (16,418 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Foetal exposure during pregnancy 1,078 reports
Depression 1,017 reports
Anxiety 966 reports
Emotional distress 789 reports
Anhedonia 708 reports
See full Raltegravir drug information
Keep checking

Other Drugs & Tocotrienols

Browse every other medication we’ve checked against Tocotrienols — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
122Minor
2,707No known interaction
122 Minor 2,707 No interaction
Minor

122 interactions

Showing 60 of 122 minor interactions — see all 122 on the Tocotrienols page.

No interaction 2,707 drugs checked — show the list

We also checked Tocotrienols against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Tocotrienols list.

See the full Tocotrienols interactions page
See every supplement checked against Raltegravir, ranked by severity
Evidence & sources

Tocotrienols References

The 4 references that drive our Tocotrienols monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tocotrienols and Raltegravir Together: Common Questions

Is it safe to take Tocotrienols with Raltegravir?
We do not list a known interaction between Tocotrienols and Raltegravir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Tocotrienols and Raltegravir combination checked?
Interactions in our licensed database are recorded against drug classes. Raltegravir is filed under 4 classifications, and Tocotrienols has documented interactions with 1 drug class — none of Raltegravir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tocotrienols interact with any other medications?
Yes. Tocotrienols has 122 documented drug interactions in our database — Raltegravir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Raltegravir interact with any supplements?
Yes. Raltegravir has documented interactions with 33 supplements in our database — Tocotrienols is not one of them. The Raltegravir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tocotrienols monograph Uses, safety profile, and every drug interaction in one place Raltegravir drug information The full plain-English guide to this medication Raltegravir supplement interactions Every supplement checked against Raltegravir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Raltegravir and Tocotrienols?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.