Drug & supplement interaction

Vitamin C + Ifosfamide

Ifosfamide brand name: Ifex.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Vitamin C has a moderate interaction with Ifosfamide. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Vitamin C and Ifosfamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ALKYLATING AGENTS

Why this applies to Ifosfamide

Ifosfamide falls under ALKYLATING AGENTS — the group Vitamin C interacts with.

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thinking behind this one. Ifosfamide is a chemotherapy drug that partly works by creating reactive, damaging molecules (free radicals) inside cancer cells to help kill them. Because vitamin C is an antioxidant, the theoretical worry is that high doses could soak up some of those free radicals and, in theory, make the chemo work a little less well. That's the concern on file here.

I want to be honest about the evidence though: this is theoretical, based on how these drugs behave, not on solid studies. Researchers genuinely disagree, and some think antioxidants might even help. The amount of vitamin C in food is not the issue. The real question is concentrated supplement doses during treatment. Please don't start or stop any vitamin C on your own. Run it by your oncologist or pharmacist first, since they're guiding your chemo.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  3. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Vitamin C Also Interacts With Other Medications

Vitamin C has 100 moderate, 106 minor known drug interactions in our database — the Ifosfamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 100 Minor 106 No known interaction 2,624 (incl. Ifosfamide)
Taking anything else?

Check Another of Your Medications Against Vitamin C

Covers the 2,830 medications we’ve checked against Vitamin C. Pick one to open its full report.

From our Q&A

Questions About Vitamin C or Ifosfamide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Vitamin C or Ifosfamide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ifosfamide

This page covers Vitamin C only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ifosfamide page lists 149 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 5 major · 102 moderate · 42 minor.

From our pharmacist’s overview on the Ifosfamide page

“Grapefruit is the first thing I would take off the table during ifosfamide (Ifex) treatment, and this list as a whole deserves careful attention rather than a quick skim. Ifosfamide is chemotherapy, and the body activates it through the CYP3A4 enzyme, so supplements that block or speed up that enzyme can shift how much active drug you…”

Reviewed by 2 · Jul 18, 2026

Open the Ifosfamide interaction page

One more smart check

Taking Vitamin C as Part of a Dietary Supplement Product? Check It for Interactions

We hold 36,382 real supplement products containing Vitamin C, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vitamin C. Your product may carry other ingredients that interact with Ifosfamide too, on top of Vitamin C — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vitamin C and Ifosfamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vitamin C
Most looked up

#1 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ifosfamide
Steady interest

#2,167 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Vitamin C

What is Vitamin C?

  • Common cold and immune support
  • Antioxidant support
  • Skin health and collagen formation
  • Wound healing
  • Preventing or treating scurvy
  • Improving iron absorption

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an antioxidant, but taking large doses doesn't prevent colds for most people and may cause stomach upset. Most people get enough from a balanced diet, so check with your pharmacist or doctor before taking high-dose supplements.

Read the full Vitamin C monograph & all interactions
Medication

About Ifosfamide Injection

What Is Ifosfamide Injection Used For?

Brand name: Ifex

Ifosfamide Injection (brands: Ifex, IFOSFAMIDE) is indicated for use in combination with certain other approved cancer medicines as third-line chemotherapy for germ cell testicular cancer. It is always given alongside mesna, a protective drug that helps prevent serious bladder bleeding.

See full Ifosfamide Injection drug information
Keep checking

Other Drugs & Vitamin C

Browse every other medication we’ve checked against Vitamin C — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
100Moderate
106Minor
2,623No known interaction
100 Moderate 106 Minor 2,623 No interaction
Moderate

100 interactions

Showing 60 of 100 moderate interactions — see all 100 on the Vitamin C page.

Minor

106 interactions

Showing 60 of 106 minor interactions — see all 106 on the Vitamin C page.

No interaction 2,623 drugs checked — show the list

We also checked Vitamin C against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,623 medications checked with no known interaction — see the full Vitamin C list.

See the full Vitamin C interactions page
See every supplement checked against Ifosfamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Vitamin C monograph › Uses, safety, and every drug interaction in one place Ifosfamide supplement interactions › Every supplement checked against Ifosfamide, ranked by severity Ifosfamide Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Vitamin C and Ifosfamide Together: Common Questions

Can you take Vitamin C with Ifosfamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Vitamin C and Ifosfamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ifosfamide and Vitamin C?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.