Vitamin C + Atorvastatin
Atorvastatin brand name: Atorvaliq.
We found no known interaction between Vitamin C and Atorvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Vitamin C and Atorvastatin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Atorvastatin and Vitamin C in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Vitamin C safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Atorvastatin
Interactions in our licensed database are recorded against drug classes, not just single drug names. Atorvastatin is filed under 7 classifications — including hmg-coa reductase inhibitors ("statins"), organic anion-transporting polypeptide substrates (oatp), glucuronidated drugs. Vitamin C has documented interactions with 13 drug classes — the most serious being alkylating agents (moderate), aluminum (moderate) and antitumor antibiotics (moderate) — and none of Atorvastatin’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Vitamin C Does Interact With Other Medications
Vitamin C has 101 moderate, 106 minor known drug interactions in our database — Atorvastatin isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Vitamin C
We haven’t checked that one against Vitamin C yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Vitamin C. Pick one to open its full report.
Vitamin C in Pregnancy & Breastfeeding
When used orally and appropriately.
When used orally in excessive doses. Tell patients over age 19 not to use doses exceeding the UL of 2000 mg daily when pregnant or breast-feeding and for those 14-18 years of age not to use doses exceeding 1800 mg daily when pregnant or breast-feeding. Higher doses can cause osmotic diarrhea and gastrointestinal upset. Large doses of vitamin C during pregnancy can also cause newborn scurvy; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Atorvastatin Is Prescribed For, and What Vitamin C Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Atorvastatin is a prescription medicine with approved uses on its FDA label. Vitamin C is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Atorvastatin is prescribed for: Atorvastatin is used alongside a healthy diet to lower LDL ("bad") cholesterol, triglycerides (blood fats), and other harmful lipids, while raising HDL ("good") cholesterol. It treats primary hyperlipidemia (high cholesterol), mixed dyslipidemia (mixed abnormal blood fats), hypertriglyceridemia (high triglycerides), and inherited conditions such as heterozygous and homozygous familial hypercholesterolemia — including in children aged 10 and older. Beyond cholesterol control, atorvastatin is used to reduce the risk of heart attack, stroke, revascularization procedures, and angina (chest pain) in adults with coronary heart disease or multiple risk factors for it — including adults with type 2 diabetes who have risk factors for heart disease even without a confirmed heart disease diagnosis.
Vitamin C has been studied for:
-
Hypercholesterolemia Natural Medicines rates the evidence for Vitamin C: Possibly Effective Read what the research shows
Vitamin C for hypercholesterolemia
Oral vitamin C seems to reduce lipid levels in patients with hypercholesterolemia.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Atorvastatin on your own; if you are taking Vitamin C for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Vitamin C or Atorvastatin
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Vitamin C or Atorvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Take Vitamin C Supplements With A Multivitamin? ›
- Can I Take Ginkgo With Apixaban (Eliquis) and Atorvastatin? ›
- What Supplements or Foods Help Prevent Catching a Cold? ›
- Is It Safe to Eat Pomegranate Seeds With Pravastatin? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Atorvastatin
This page covers Vitamin C only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atorvastatin page lists 181 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Green Tea (major).
By severity: 9 major · 136 moderate · 36 minor.
From our pharmacist’s overview on the Atorvastatin page
“Grapefruit is the entry to understand first. Atorvastatin (Atorvaliq) is cleared by an enzyme called CYP3A4, and grapefruit blocks that enzyme, letting statin levels climb along with the risk of side effects like muscle pain.”
Reviewed by 2 · Jul 18, 2026
Taking Vitamin C as Part of a Dietary Supplement Product? Check It for Interactions
We hold 36,382 real supplement products containing Vitamin C, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vitamin C. Even though Vitamin C itself has no known interaction with Atorvastatin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Vitamin C and Atorvastatin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1 of 1,452 supplements looked up here in the last 7 days
#27 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vitamin C reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Vitamin C and Atorvastatin records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Vitamin C
What is Vitamin C?
- Common cold and immune support
- Antioxidant support
- Skin health and collagen formation
- Wound healing
- Preventing or treating scurvy
- Improving iron absorption
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an antioxidant, but taking large doses doesn't prevent colds for most people and may cause stomach upset. Most people get enough from a balanced diet, so check with your pharmacist or doctor before taking high-dose supplements.
Not applicable (a water-soluble vitamin; found in fruits and vegetables) · Tablets, capsules, chewables, gummies, effervescent powders, liquids, and intravenous (in medical settings)
An interaction check asks whether these two react with each other — it does not ask whether Vitamin C is a good idea for someone in your situation. Here is what our Vitamin C record says about it on its own.
Vitamin C: dosing
For everyday nutrition, vitamin C needs are met through a balanced diet and standard multivitamins, and recommended daily amounts vary by age, sex, and life stage. Smokers generally need somewhat more.There is no single agreed-upon "treatment" dose for the supplement uses people are interested in. Because high doses can cause stomach upset and other problems, more is not always better.
From our Vitamin C monograph — the full record covers uses, side effects and every documented interaction.
About Atorvastatin
What Is Atorvastatin Used For?
Brand name: Atorvaliq
Atorvastatin is used alongside a healthy diet to lower LDL ("bad") cholesterol, triglycerides (blood fats), and other harmful lipids, while raising HDL ("good") cholesterol. It treats primary hyperlipidemia (high cholesterol), mixed dyslipidemia (mixed abnormal blood fats), hypertriglyceridemia (high triglycerides), and inherited conditions such as heterozygous and homozygous familial hypercholesterolemia — including in children aged 10 and older.
Beyond cholesterol control, atorvastatin is used to reduce the risk of heart attack, stroke, revascularization procedures, and angina (chest pain) in adults with coronary heart disease or multiple risk factors for it — including adults with type 2 diabetes who have risk factors for heart disease even without a confirmed heart disease diagnosis.
Other Drugs & Vitamin C
Browse every other medication we’ve checked against Vitamin C — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
101 interactions
- Estradiol ›
- Levothyroxine ›
- Doxorubicin ›
- Aluminum Chloride ›
- Conjugated Estrogens ›
- Aluminum Hydroxide ›
- Bendamustine ›
- Carmustine ›
- Fluphenazine ›
- Levothyroxine Sodium ›
- Mitomycin ›
- Warfarin Sodium ›
- Busulfan ›
- Cyclophosphamide ›
- Dactinomycin ›
- Esterified Estrogens ›
- Estropipate ›
- Melphalan ›
- Retapamulin ›
- Thiotepa ›
- Altretamine ›
- Bendamustine Hydrochloride ›
- Bleomycin ›
- Carboplatin ›
- Chlorambucil ›
- Cisplatin ›
- Dacarbazine ›
- Daunorubicin Citrate ›
- Daunorubicin Hydrochloride ›
- Dihydroxyaluminum Sodium Carbonate ›
- Doripenem ›
- Epirubicin ›
- Estramustine Phosphate Sodium ›
- Estrogen ›
- Estrone ›
- Ethinyl Estradiol ›
- Fish Oil Triglycerides ›
- Idarubicin ›
- Ifosfamide ›
- Indinavir ›
- Lomustine ›
- Lurbinectedin ›
- Mechlorethamine Hydrochloride ›
- Melphalan Flufenamide ›
- Melphalan Hydrochloride ›
- Mitomycin C ›
- Mitoxantrone ›
- Oestrogen ›
- Oxaliplatin ›
- Prasterone (prescription Drug) ›
- Procarbazine ›
- Streptozocin ›
- Temozolomide ›
- Tibolone ›
- Tigecycline ›
- Trabectedin ›
- Valrubicin ›
- Warfarin ›
- Ethinyl Estradiol, Norethindrone ›
- Ethinyl Estradiol, Levonorgestrel ›
Showing 60 of 101 moderate interactions — see all 101 on the Vitamin C page.
106 interactions
- Aspirin ›
- Salsalate ›
- Acetaminophen ›
- Choline Magnesium Trisalicylate ›
- Magnesium Sulfate (prescription Drug) ›
- Niacin (prescription Drug) ›
- Acetylsalicylic Acid ›
- Paracetamol ›
- Acetaminophen, Hydrocodone ›
- Acetaminophen, Butalbital ›
- Acetaminophen, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Pseudoephedrine ›
- Acetaminophen, Butalbital, Caffeine ›
- Acetaminophen, Caffeine, Codeine ›
- Aspirin, Caffeine, Orphenadrine ›
- Acetaminophen, Dextromethorphan, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine ›
- Acetaminophen, Dichloralantipyrine, Isometheptene ›
- Acetaminophen, Oxycodone ›
- Acetaminophen, Propoxyphene ›
- Acetaminophen, Aspirin, Caffeine ›
- Acetaminophen, Caffeine, Codeine, Salicylamide ›
- Acetaminophen, Caffeine, Dihydrocodeine ›
- Acetaminophen, Chlorpheniramine, Phenylephrine ›
- Acetaminophen, Chlorzoxazone ›
- Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine ›
- Acetaminophen, Diphenhydramine, Pseudoephedrine ›
- Acetaminophen, Pamabrom, Pyrilamine ›
- Acetaminophen, Butalbital, Caffeine, Codeine ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide ›
- Acetaminophen, Chlorzoxazone, Codeine ›
- Acetaminophen, Codeine ›
- Acetaminophen, Codeine, Methocarbamol ›
- Acetaminophen, Diphenhydramine ›
- Acetaminophen, Phenyltoloxamine ›
- Aspirin, Caffeine, Dover's Pwd ›
- Aspirin, Dipyridamole ›
- Aspirin, Hydrocodone ›
- Acetaminophen, Aspirin ›
- Acetaminophen, Brompheniramine, Phenylpropanolamine ›
- Acetaminophen, Butalbital, Codeine ›
- Acetaminophen, Butalbital, Codeine Phosphate ›
- Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine ›
- Acetaminophen, Caffeine, Isometheptene ›
- Acetaminophen, Caffeine, Pyrilamine ›
- Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr ›
- Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine ›
- Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine ›
- Acetaminophen, Codeine, Doxylamine ›
- Acetaminophen, Dexbrompheniramine, Pseudoephedrine ›
- Acetaminophen, Dextromethorphan ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine ›
- Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine ›
Showing 60 of 106 minor interactions — see all 106 on the Vitamin C page.
No interaction 2,622 drugs checked — show the list
We also checked Vitamin C against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Vitamin C list.
Vitamin C References
The 51 references that drive our Vitamin C monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
- Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
- Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
- Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
- Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. PubMed
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
- Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
- Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
- Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. PubMed
- Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
- Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
- Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
- Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
- Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
- Dysken MW, Cumming RJ, Channon RA, Davis JM. Drug interaction between ascorbic acid and fluphenazine. JAMA 1979;241:2008. DOI
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
- Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed
- Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. PubMed
- Lee DH, Folsom AR, Harnack L, et al. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr 2004;80:1194-200. PubMed
- Taylor EN, Stampfer MJ, Curhan GC. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol 2004;15:3225-32. PubMed
- Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
- Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
- Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
- Fairweather-Tait S, Hickson K, McGaw B, et al. Orange juice enhances aluminium absorption from antacid preparation. Eur J Clin Nutr. 1994;48(1):71-3.
- Gruenwald, J., Graubaum, H. J., Busch, R., and Bentley, C. Safety and tolerance of ester-C compared with regular ascorbic acid. Adv.Ther. 2006;23(1):171-178.
- Rahimi, R., Nikfar, S., Rezaie, A., and Abdollahi, M. A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women. Hypertens.Pregnancy. 2009;28(4):417-434. PubMed
- Einerson, B., Nathorn, C., Kitiyakara, C., Sirada, M., and Thamlikitkul, V. The efficacy of ascorbic acid in suboptimal responsive anemic hemodialysis patients receiving erythropoietin: a meta-analysis. J Med.Assoc.Thai. 2011;94 Suppl 1:S134-S146.
- Li, G., Li, L., Yu, C., and Chen, L. Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis. Br.J Nutr 2011;106(11):1632-1637.
- Chen X, Shen L, Gu X, et al. High-dose supplementation with vitamin C--induced pediatric urolithiasis: the first case report in a child and literature review. Urology. 2014;84(4):922-4. PubMed
- Sattar A, Willman JE, Kolluri R. Possible warfarin resistance due to interaction with ascorbic acid: case report and literature review. Am J Health Syst Pharm. 2013;70(9):782-6. PubMed
- Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due to excess vitamin C intake: a cause of graft loss in a renal transplant recipient. Saudi J Kidney Dis Transpl. 2014;25(1):113-6. PubMed
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
- Rumbold A, Ota E, Nagata C, Shahrook S, Crowther CA. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev. 2015;(9):CD004072. PubMed
- Seo MS, Kim JK, Shim JY. High-dose vitamin C promotes regression of multiple pulmonary metastases originating from hepatocellular carcinoma. Yonsei Med J. 2015;56(5):1449-52. PubMed
- Skelin M, Lucijanic T, Amidzic Klaric D, et al. Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review. Clin Ther. 2017 Feb;39(2):378-403. PubMed
- Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z. Ascorbic acid supplements and kidney stones incidence among men and women: a systematic review and meta-analysis. Urol J. 2019;16(2):115-120.
- Thomas S, Patel D, Bittel B, et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2 PubMed
- Giffen MA, McLemore JL. Hyperoxalosis Secondary to Intravenous Vitamin C Administration as a Non-Allopathic Treatment for Cancer. Acad Forensic Pathol 2019;9(1-2):118-126. PubMed
- Maike A, Sturgill D, Gallan A. Oxalate Nephropathy in a Renal Transplant Recipient After Receiving High Dose Ascorbic Acid. Am J Med Sci 2021. PubMed
- Shen ZY, Chen YR, Wang MC, Chang SS. High-dose vitamin C-induced acute oxalate nephropathy in a renal transplant recipient: a case report and literature review. Asian J Surg 2022. PubMed
- Yanase F, Spano S, Maeda A, et al. Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial. Crit Care 2023;27(1):371. PubMed
- Sharma Y, Sumanadasa S, Shahi R, et al. Efficacy and safety of vitamin C supplementation in the treatment of community-acquired pneumonia: a systematic review and meta-analysis with trial sequential analysis. Sci Rep 2024;14(1):11846. PubMed
- Pejcic AV, Petrovic NZ, Djordjic MD, Milosavljevic MN. Vitamin C Levels in Pregnant Women and the Efficacy of Vitamin C Supplements in Preventing Premature Rupture of Membranes: A Systematic Review and Meta-Analysis. Balkan Med J 2024;41(4):248-260. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Atorvastatin Is Linked to Lower Levels of 2 Nutrients
Natural Medicines records Atorvastatin as a medicine that can lower these. This is not an interaction with Vitamin C — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Atorvastatin nutrient depletion report ›
Vitamin C is itself a nutrient we track — see which medications may deplete VITAMIN C.
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Vitamin C and Atorvastatin Together: Common Questions
Is it safe to take Vitamin C with Atorvastatin?
Are Vitamin C and Atorvastatin used for the same thing?
How was the Vitamin C and Atorvastatin combination checked?
Does Vitamin C interact with any other medications?
Does Atorvastatin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.