Drug & supplement interaction

Wine + Tofacitinib

Tofacitinib brand names: Xeljanz, Xeljanz XR.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wine and Tofacitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wine and Tofacitinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tofacitinib and Wine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wine safety at a glance

Wine overall Use caution Wine contains alcohol, which can harm health and become habit-forming even in moderate amounts.
Pregnancy Likely Unsafe When used orally; alcohol is a teratogen. Use during pregnancy is associated with significant risk of spontaneous abortion, fetal alcohol syndrome, and developm... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Alcohol is secreted in breast milk. Chronic use can cause abnormal psychomotor development and disrupt the infant's sleep-wake pattern. Alcoho... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tofacitinib and Wine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tofacitinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tofacitinib is filed under 4 classifications — including cytochrome p450 2c19 (cyp2c19) substrates, immunosuppressants, cytochrome p450 3a4 (cyp3a4) substrates. Wine has documented interactions with 37 drug classes — the most serious being aspirin (major), cisapride (propulsid) (major) and cns depressants (major) — and none of Tofacitinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wine Does Interact With Other Medications

Wine has 656 major, 270 moderate known drug interactions in our database — Tofacitinib isn’t one of them. If you take anything else, check it against the full list below.

Major 656 Moderate 270 No known interaction 1,904 (incl. Tofacitinib)
Taking anything else?

Check Another of Your Medications Against Wine

Covers the 2,830 medications we’ve checked against Wine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wine and Tofacitinib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Low blood sugar Worth acting on Additional detail

    Wine

    “Orally, the side effects of wine depend on the amount of alcohol ingested and can vary among individuals.

    Most Common Adverse Effects:

    Orally: Most adverse effects are associated with alcohol content and include abdominal pain, aggression, blackouts, central nervous system (CNS) depression, confusion, diarrhea, drowsiness, emotional lability, flushing, hypoglycemia, hypothermia, indigestion, lack of coordination and…”

    Wine · Natural Medicines adverse-effect record, reported in cancer.

    Tofacitinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Tofacitinib. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Wine

    “Orally, chronic heavy alcohol ingestion (three or more drinks daily) can lead to cirrhosis and hepatotoxicity.”

    Wine · Natural Medicines adverse-effect record, reported in cirrhosis.

    2 sources cited
    1. 6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.
    2. 9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed

    Tofacitinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Tofacitinib. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Wine

    “People who are allergic to sulfites and/or yeast might react to wine. Wine is associated with triggering asthmatic reactions in people with a history of asthma, possibly due to salicylates and/or added sulfites contained in wines. A case report describes a 33-year-old female who developed allergic reactions ranging from mild symptoms to anaphylaxis after consumption of beer or wine.”

    Wine · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 6174. Vally H, de Klerk N, Thompson PJ. Alcoholic drinks: important triggers for asthma. J Allergy Clin Immunol 2000;105:462-7. PubMed
    2. 107819. German-Sanchez A, Alonso-Llamazares A, Garcia-Gonzalez F, Matala-Ahmed B, Bartolome-Zavala B, Antepara-Ercoreca I. Allergy to beer and wine caused by Saccharomyces cerevisiae in a patient sensitized to fungi. J Investig Allergol Clin Immunol 2021. PubMed

    Tofacitinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Tofacitinib. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Wine

    “Orally, wine can cause a variety of side effects which depend on the amount of alcohol ingested and can vary among individuals. Some common side effects include abdominal pain, diarrhea, indigestion, nausea, and vomiting.. Chronic alcohol use is also associated with pancreatitis.”

    Wine · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.
    2. 8972. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed
    3. 9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed
    4. 34013. Bode, C. and Bode, J. C. Alcohol's role in gastrointestinal tract disorders. Alcohol Health Res World 1997;21(1):76-83.
    5. 34031. Pehl, C., Wendl, B., and Pfeiffer, A. White wine and beer induce gastro-oesophageal reflux in patients with reflux disease. Aliment.Pharmacol Ther 6-1-2006;23(11):1581-1586. PubMed

    Tofacitinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Tofacitinib. Read the label on DailyMed ›

Reported for Wine but not commonly for Tofacitinib: a heart attack, dependence or withdrawal symptoms, an irregular heartbeat and mood changes or irritability.

Effects for Tofacitinib come from the ADVERSE REACTIONS section of its FDA label; effects for Wine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 185,980 voluntary FDA FAERS reports for Tofacitinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Wine in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; alcohol is a teratogen. Use during pregnancy is associated with significant risk of spontaneous abortion, fetal alcohol syndrome, and developmental and behavioral dysfunction in infants and children exposed to alcohol in utero; avoid using.

Lactation Likely Unsafe

When used orally. Alcohol is secreted in breast milk. Chronic use can cause abnormal psychomotor development and disrupt the infant's sleep-wake pattern. Alcohol also seems to reduce milk production; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Tofacitinib

This page covers Wine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tofacitinib page lists 184 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 143 moderate · 38 minor.

From our pharmacist’s overview on the Tofacitinib page

“Supplements deserve genuine care alongside tofacitinib (Xeljanz, Xeljanz XR), a medicine that deliberately dials down the immune system to control conditions like rheumatoid arthritis and ulcerative colitis. Most of the interactions on this page run through the liver enzymes that clear the drug, meaning an herb can push its blood level…”

Reviewed by 2 · Jul 18, 2026

Open the Tofacitinib interaction page

One more smart check

Taking Wine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Wine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wine. Even though Wine itself has no known interaction with Tofacitinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wine and Tofacitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wine
Top half

#418 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tofacitinib
Steady interest

#1,579 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wine and Tofacitinib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wine

What is Wine?

  • Social and relaxation use
  • Heart health (popular belief)
  • Antioxidant intake
  • Aiding digestion (traditional use)
  • Culinary flavoring

Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine. Despite popular claims about heart benefits, the alcohol it contains carries real health risks, and no amount of drinking can be recommended to improve health. If you drink, do so in moderation, and avoid alcohol entirely during pregnancy or if you have certain medical conditions.

Fermented grapes (or other fruit) · Red wine, white wine, rosé, sparkling wine, fortified wine

An interaction check asks whether these two react with each other — it does not ask whether Wine is a good idea for someone in your situation. Here is what our Wine record says about it on its own.

Wine: dosing

There is no medicinal or supplement "dose" for wine, and no amount is recommended to improve health. If a person chooses to drink, public health guidelines generally define moderate drinking as up to one standard drink per day for women and up to two for men, with a standard drink being about 5 ounces of wine.Less is always better when it comes to alcohol, and not drinking at all is the safest choice.

From our Wine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wine monograph & all interactions
Medication

About Tofacitinib

What Is Tofacitinib Used For?

Brand names: Xeljanz, Xeljanz XR

  • Tofacitinib is used alone or with other medications to treat rheumatoid arthritis (condition in which the body attacks its own joints causing pain, swelling, and loss of function) in adults who are unable to take or did not respond to one or more tumor necrosis factor (TNF) inhibitor medication(s). It is also used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults who are unable to take or did not respond to or tolerate one or more TNF inhibitor medication(s). Tofacitinib is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults who are unable to take or who did not respond to one or more TNF inhibitor medication(s). It is also used to treat polyarticular juvenile idiopathic arthritis (PJIA; a type of childhood arthritis that affects five or more joints during the first six months of the condition, causing pain, swelling, and loss of function) in children 2 years and older who are unable to take or who did not respond to one or more TNF inhibitor medication(s). Tofacitinib is in a class of medications called Janus kinase (JAK) inhibitors. It works by decreasing the activity of the immune system.

See full Tofacitinib drug information
Keep checking

Other Drugs & Wine

Browse every other medication we’ve checked against Wine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

656Major
270Moderate
0Minor
1,903No known interaction
656 Major 270 Moderate 1,903 No interaction
Major

656 interactions

Showing 60 of 656 major interactions — see all 656 on the Wine page.

Moderate

270 interactions

Showing 60 of 270 moderate interactions — see all 270 on the Wine page.

No interaction 1,903 drugs checked — show the list

We also checked Wine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,903 medications checked with no known interaction — see the full Wine list.

See the full Wine interactions page
See every supplement checked against Tofacitinib, ranked by severity
Evidence & sources

Wine References

The 73 references that drive our Wine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  2. Hart CL, Smith GD, Hole DJ, Hawthorne VM. Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up. BMJ 1999;318:1725-9. PubMed
  3. Offman EM, Freeman DJ, Dresser GK, et al. Cisapride interaction with grapefruit juice and red wine. Clin Pharmacol Ther 2000;67:110 (abstract PI-83).
  4. Tsunoda SM, Christians U, Velez RL, et al. Red wine (RW) effects on cyclosporine (CyA) metabolites. Clin Pharmacol Ther 2000;67:150 (abstract PIII-35).
  5. Tsunoda SM, Harris RZ, Velez RL, et al. Red wine (RW) effects on cyclosporine (CyA) Pharmacokinetics. Clin Pharmacol Ther 1998;65:159 (abstract PII-51). DOI
  6. Pearson TA. Alcohol and heart disease. Circulation 1996;94:3023-5. PubMed
  7. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
  8. Stampfer MJ, Colditz GA, Willett WC, et al. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med 1988;319:267-73. PubMed
  9. Vally H, de Klerk N, Thompson PJ. Alcoholic drinks: important triggers for asthma. J Allergy Clin Immunol 2000;105:462-7. PubMed
  10. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.
  11. Goldberg I, Mosca L, Piano MR, Fisher EA. AHA Science Advisory: Wine and your heart: a science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the America
  12. Michaud DS, Giovannucci E, Willett WC, et al. Coffee and alcohol consumption and risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev 2001;10:429-37.
  13. Dufour MC. If you drink alcoholic beverages do so in moderation: what does this mean? J Nutr 2001;131:552S-61S. PubMed
  14. Thadhani R, Camargo CA, Stampfer MJ, et al. Prospective study of moderate alcohol consumption and risk of hypertension in young women. Arch Intern Med 2002;162:569-74. PubMed
  15. Mukamal KJ, Longstreth WT, Mittleman MA. Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health study. Stroke 2001;32:1939-46. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wine and Tofacitinib Together: Common Questions

Is it safe to take Wine with Tofacitinib?
We do not list a known interaction between Wine and Tofacitinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wine and Tofacitinib have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Wine and Tofacitinib combination checked?
Interactions in our licensed database are recorded against drug classes. Tofacitinib is filed under 4 classifications, and Wine has documented interactions with 37 drug classes — none of Tofacitinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wine interact with any other medications?
Yes. Wine has 926 documented drug interactions in our database — Tofacitinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tofacitinib interact with any supplements?
Yes. Tofacitinib has documented interactions with 184 supplements in our database — Wine is not one of them. The Tofacitinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wine monograph Uses, safety profile, and every drug interaction in one place Tofacitinib drug information The full plain-English guide to this medication Tofacitinib supplement interactions Every supplement checked against Tofacitinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 73 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tofacitinib and Wine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.