Drug & supplement interaction

Witch Hazel + Mitoxantrone

Mitoxantrone brand name: Novantrone.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Witch Hazel and Mitoxantrone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Witch Hazel and Mitoxantrone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mitoxantrone and Witch Hazel in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Witch Hazel at all — not against Mitoxantrone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Witch Hazel safety at a glance

Witch Hazel overall Use caution Generally well tolerated on the skin short-term, but not meant to be taken by mouth.
Pregnancy Use caution Topical use is likely low risk, but data are limited; avoid oral use and ask your doctor first.
Breastfeeding Use caution Limited safety data; topical use is likely low risk but check with your doctor, and avoid applying to the nipple area.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mitoxantrone and Witch Hazel? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Witch Hazel and Mitoxantrone May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Witch Hazel

    “Topically, witch hazel is generally well tolerated. Orally, witch hazel seems to be well tolerated at appropriate doses, but high doses may be associated with more adverse effects due to the tannin content in witch hazel.

    Most Common Adverse Effects:

    Topically: Contact dermatitis.

    Serious Adverse Effects (Rare):

    Orally: Kidney and liver damage when preparations containing at least 10% tannins are used in high doses.”

    Witch Hazel · Natural Medicines adverse-effect record, reported in dermatitis.

    Mitoxantrone

    Listed in the ADVERSE REACTIONS section of the FDA label for Mitoxantrone. Read the label on DailyMed ›

Reported for Witch Hazel but not commonly for Mitoxantrone: a skin rash.

Effects for Mitoxantrone come from the ADVERSE REACTIONS section of its FDA label; effects for Witch Hazel come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Mitoxantrone Is Prescribed For, and What Witch Hazel Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Mitoxantrone is a prescription medicine with approved uses on its FDA label. Witch Hazel is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Mitoxantrone is prescribed for: Mitoxantrone Injection is used to reduce neurologic disability and the frequency of relapses in adults with secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis (MS). It is not indicated for primary progressive MS. Mitoxantrone Injection, in combination with corticosteroids, is also used as initial chemotherapy for pain related to advanced hormone-refractory prostate cancer. In combination with other approved drugs, it is used in the initial treatment of acute nonlymphocytic leukemia (ANLL) in adults, which includes several subtypes such as myelogenous, promyelocytic, monocytic, and erythroid acute leukemias.

Witch Hazel has been studied for:

  • Cancer studied, not established Witch Hazel has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Witch Hazel for cancer

    Although there has been interest in using oral and topical witch hazel for cancer, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Mitoxantrone on your own; if you are taking Witch Hazel for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Mitoxantrone

This page covers Witch Hazel only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mitoxantrone page lists 25 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Acerola (moderate), Alpha-lipoic Acid (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).

By severity: 1 major · 15 moderate · 9 minor.

From our pharmacist’s overview on the Mitoxantrone page

“Very little here is casual, because mitoxantrone (Novantrone) is chemotherapy for certain cancers and aggressive multiple sclerosis, and anything that weakens it can cost real ground. The one major-rated interaction, activated charcoal, can pull the drug back out of the body even though mitoxantrone is given by IV.”

Reviewed by 2 · Jul 18, 2026

Open the Mitoxantrone interaction page

One more smart check

Taking Witch Hazel as Part of a Dietary Supplement Product? Check It for Interactions

We hold 150 real supplement products containing Witch Hazel, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Witch Hazel. Even though Witch Hazel itself has no known interaction with Mitoxantrone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Witch Hazel and Mitoxantrone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Witch Hazel
Top half

#621 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mitoxantrone
Top half

#834 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Witch Hazel reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Witch Hazel and Mitoxantrone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Witch Hazel

What is Witch Hazel?

  • Skin irritation and inflammation
  • Hemorrhoids
  • Minor cuts and bruises
  • Oily or acne-prone skin
  • Itching and minor swelling
  • Soothing after shaving or sun exposure

Witch hazel is a plant-based astringent used mostly on the skin for minor irritation, hemorrhoids, and oily skin. It is generally well tolerated as a topical product for short-term use, but evidence for most uses is limited, and it should not be swallowed. Check with your pharmacist or doctor before using it, especially during pregnancy or breastfeeding.

Hamamelis virginiana · Hamamelidaceae · Bark, leaves, and twigs · Liquid astringent (distilled water), gels, ointments, creams, wipes/pads, suppositories, soaps

An interaction check asks whether these two react with each other — it does not ask whether Witch Hazel is a good idea for someone in your situation. Here is what our Witch Hazel record says about it on its own.

Witch Hazel: dosing

There is no official standardized dose for witch hazel. The right amount depends on the product and the form, such as a liquid, gel, pad, or ointment.The safest approach is to follow the directions on the product label and use it only on the skin as directed. For hemorrhoid pads or creams, follow the package instructions. Do not take witch hazel by mouth unless a healthcare professional specifically advises it.

From our Witch Hazel monograph — the full record covers uses, side effects and every documented interaction.

Read the full Witch Hazel monograph & all interactions
Medication

About Mitoxantrone Injection

What Is Mitoxantrone Injection Used For?

Brand name: Novantrone

Mitoxantrone Injection is used to reduce neurologic disability and the frequency of relapses in adults with secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis (MS). It is not indicated for primary progressive MS.

Mitoxantrone Injection, in combination with corticosteroids, is also used as initial chemotherapy for pain related to advanced hormone-refractory prostate cancer. In combination with other approved drugs, it is used in the initial treatment of acute nonlymphocytic leukemia (ANLL) in adults, which includes several subtypes such as myelogenous, promyelocytic, monocytic, and erythroid acute leukemias.

See full Mitoxantrone Injection drug information
Keep checking

Other Drugs & Witch Hazel

Browse every other medication we’ve checked against Witch Hazel — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Witch Hazel against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Witch Hazel list.

See the full Witch Hazel interactions page
See every supplement checked against Mitoxantrone, ranked by severity
Evidence & sources

Witch Hazel References

The 7 references that drive our Witch Hazel monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  4. Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
  5. Wolff, H. H. and Kieser, M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur.J.Pediatr. 2007;166(9):943-948. PubMed
  6. Khanna, N. and Datta, Gupta S. Rejuvenating facial massage--a bane or boon? Int J Dermatol. 2002;41(7):407-410. PubMed
  7. Theisen LL, Erdelmeier CA, Spoden GA, Boukhallouk F, Sausy A, Florin L, Muller CP. Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus. PLoS One. 201 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Witch Hazel and Mitoxantrone Together: Common Questions

Is it safe to take Witch Hazel with Mitoxantrone?
We do not list a known interaction between Witch Hazel and Mitoxantrone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Witch Hazel and Mitoxantrone have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Witch Hazel and Mitoxantrone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Witch Hazel in each. That is a conversation for your prescriber, especially if Mitoxantrone is being adjusted to a target.
Does Mitoxantrone interact with any supplements?
Yes. Mitoxantrone has documented interactions with 25 supplements in our database — Witch Hazel is not one of them. The Mitoxantrone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Witch Hazel monograph Uses, safety profile, and every drug interaction in one place Mitoxantrone Injection drug information The full plain-English guide to this medication Mitoxantrone supplement interactions Every supplement checked against Mitoxantrone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mitoxantrone and Witch Hazel?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.