Medication interaction hub

What Supplements Interact with Acetaminophen, Chlorpheniramine, Phenylephrine?

Acetaminophen, Chlorpheniramine, Phenylephrine brand names: Protid, Histex SR, Alka-Seltzer PLUS. Every interaction below applies to the brands too.

292 Interactions 14 Major 232 Moderate 46 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Chlorpheniramine, Phenylephrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Chlorpheniramine, Phenylephrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Picture the week you are sick enough to reach for Alka-Seltzer PLUS or another acetaminophen, chlorpheniramine, and phenylephrine combination, while still taking whatever supplements you always take. That is where trouble hides, and with 14 of its 292 supplement interactions rated major, this medicine warrants real vigilance. Stimulant herbs like ephedra can stack with phenylephrine and push blood pressure higher. Alcohol raises the odds of liver harm on top of acetaminophen. And herbs with drying, sedating anticholinergic effects intensify what chlorpheniramine already does.

The rest of the list tilts toward metabolism, with 232 moderate and 46 minor entries mostly changing how quickly the body clears one of the three drugs. Grapefruit and St. John's wort do this strongly enough to rate major themselves. If something you take appears among those fourteen major entries below, that pairing is the one to rethink first.

— , Clinical Pharmacist · July 18, 2026

Major 14 Moderate 232 Minor 46 No known interaction 1,160

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Chlorpheniramine, Phenylephrine: Top Interactions at a Glance

The Acetaminophen, Chlorpheniramine, Phenylephrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 292 interacting ingredients — plus 1,160 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Chlorpheniramine, Phenylephrine Combinations Today

The Acetaminophen, Chlorpheniramine, Phenylephrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Cannabidiol (cbd) + Acetaminophen, Chlorpheniramine, Phenylephrinei

Cannabidiol may increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Probable Glucomannan + Acetaminophen, Chlorpheniramine, Phenylephrinei

Theoretically, glucomannan may decrease absorption of drugs taken orally.

Read the full interaction Moderate Likelihood Probable Coffee + Acetaminophen, Chlorpheniramine, Phenylephrinei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Probable Caffeine + Acetaminophen, Chlorpheniramine, Phenylephrinei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Goldenseal + Acetaminophen, Chlorpheniramine, Phenylephrinei

Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Vitamin D + Acetaminophen, Chlorpheniramine, Phenylephrinei

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Chlorpheniramine, Phenylephrine

All 1,452 ingredients in our database, ranked by severity — 292 with a Acetaminophen, Chlorpheniramine, Phenylephrine interaction on file and 1,160 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Chlorpheniramine, Phenylephrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cannabidiol (cbd) with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs metabolized by CYP1A2.

Full Cannabidiol (cbd) + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Glucomannan with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Coffee with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Caffeine with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Goldenseal with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Ergot with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Certain ergot alkaloids, such as dihydroergotamine, act as serotonin agonists.

Full Ergot + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Eucalyptus with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.

Full Eucalyptus + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take European Barberry with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take False Unicorn with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Fennel with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Fermented Wheat Germ Extract with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of fermented wheat germ extract with serotonergic medications may increase the risk of serotonergic adverse e...

Full Fermented Wheat Germ Extract + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Feverfew with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.

Full Feverfew + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Fig with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.

Full Fig + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Fo-ti with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Fo-ti + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Garcinia with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin sy...

Full Garcinia + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take German Chamomile with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Ginger with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Ginkgo with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Goji with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Acetaminophen, Chlorpheniramine, Phenylephrine answer

Can you take Goldthread with Acetaminophen, Chlorpheniramine, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Acetaminophen, Chlorpheniramine, Phenylephrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Chlorpheniramine, Phenylephrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Chlorpheniramine, Phenylephrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Chlorpheniramine, Phenylephrine sits in 17 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Phenylephrine through this category.

Related: does Acetaminophen, Chlorpheniramine, Phenylephrine deplete any nutrients?

Acetaminophen, Chlorpheniramine, Phenylephrine has 3 reported nutrient associations in the research literature — see the Acetaminophen, Chlorpheniramine, Phenylephrine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Chlorpheniramine, Phenylephrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Chlorpheniramine, Phenylephrine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Acetaminophen, Chlorpheniramine, Phenylephrine & Supplements: Common Questions

What supplements interact with Acetaminophen, Chlorpheniramine, Phenylephrine?
Our database currently documents 292 ingredients with a known Acetaminophen, Chlorpheniramine, Phenylephrine interaction (14 major, 232 moderate, 46 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 292. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Acetaminophen, Chlorpheniramine, Phenylephrine supplement interactions are the most serious?
The 14 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Chlorpheniramine, Phenylephrine?
Plenty of supplements coexist fine with Acetaminophen, Chlorpheniramine, Phenylephrine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Protid have the same supplement interactions as Acetaminophen, Chlorpheniramine, Phenylephrine?
Yes — Protid, Histex SR, Alka-Seltzer PLUS all contain Acetaminophen, Chlorpheniramine, Phenylephrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Chlorpheniramine, Phenylephrine deplete any vitamins or nutrients?
It might — Acetaminophen, Chlorpheniramine, Phenylephrine has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Chlorpheniramine, Phenylephrine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Chlorpheniramine, Phenylephrine and my other medications?
This page covers Acetaminophen, Chlorpheniramine, Phenylephrine against supplements and herbal ingredients. Checking Acetaminophen, Chlorpheniramine, Phenylephrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.