Medication interaction hub

What Supplements Interact with Fluorouracil?

Fluorouracil brand names: Efudex, Tolak. Every interaction below applies to the brands too.

26 Interactions 23 Moderate 3 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fluorouracil? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fluorouracil against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you are using fluorouracil cream (Efudex, Tolak) on sun-damaged skin, your skin is already primed to react to sunlight, and that is where most of its supplement interactions sit. Of the 26 ingredients on file, 20 can make skin more sun-sensitive on their own, chlorophyll, chlorella, and bergamot oil among them, so pairing one with the medication can amplify burns and rashes. None rates major, and nothing here should derail treatment, but a few pairings are worth having on your radar.

A handful work differently. DMSO applied to the same area can pull more of the drug through the skin, and in early research high doses of folic acid or green tea increased fluorouracil's effects and side effects. Light therapy is best avoided during treatment. With 23 moderate and 3 minor entries, much of it theoretical, guarding your sun exposure covers most of the risk here.

— , Clinical Pharmacist · July 18, 2026

Moderate 23 Minor 3 No known interaction 1,426

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Fluorouracil: Top Interactions at a Glance

The most significant Fluorouracil supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 26 interacting ingredients — plus 1,426 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Fluorouracil + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Bergamot + Fluorouracili

Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.

Read the full interaction Moderate Likelihood Probable Chenopodium Oil + Fluorouracili

Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.

Read the full interaction Moderate Likelihood Probable Chlorophyll + Fluorouracili

Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.

Read the full interaction Moderate Likelihood Probable Chlorophyllin + Fluorouracili

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.

Read the full interaction Moderate Likelihood Probable Masterwort + Fluorouracili

The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effects.

Read the full interaction Moderate Likelihood Probable Wild Carrot + Fluorouracili

Theoretically, concomitant use might result in increased photosensitivity.

Read the full interaction
The complete list

Every Supplement Checked Against Fluorouracil

All 1,452 ingredients in our database, ranked by severity — 26 with a Fluorouracil interaction on file and 1,426 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fluorouracil?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Chlorophyll with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.

Full Chlorophyll + Fluorouracil answer

Can you take Chlorophyllin with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.

Full Chlorophyllin + Fluorouracil answer

Can you take Masterwort with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effec...

Full Masterwort + Fluorouracil answer

Can you take Wild Carrot with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Wild Carrot + Fluorouracil answer

Can you take Alfalfa with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + Fluorouracil answer

Can you take Angelica Archangelica with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Full Angelica Archangelica + Fluorouracil answer

Can you take Arrach with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photos...

Full Arrach + Fluorouracil answer

Can you take Bishop's Weed with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Fluorouracil answer

Can you take Chlorella with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chlorella might have additive effects with photosensitizing drugs.

Full Chlorella + Fluorouracil answer

Can you take Cilantro with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.

Full Cilantro + Fluorouracil answer

Can you take Coriander with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.

Full Coriander + Fluorouracil answer

Can you take Dimethylsulfoxide (dmso) with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Fluorouracil answer

Can you take Fig with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.

Full Fig + Fluorouracil answer

Can you take Folic Acid with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.

Full Folic Acid + Fluorouracil answer

Can you take Green Tea with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of green tea might increase the effects and side effects of 5-fluorouracil.

Full Green Tea + Fluorouracil answer

Can you take Khella with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Fluorouracil answer

Can you take Light Therapy with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Fluorouracil answer

Can you take Lime with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Fluorouracil answer

Can you take Rue with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Fluorouracil answer

Can you take St. John's Wort with Fluorouracil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Fluorouracil answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fluorouracil is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fluorouracil, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fluorouracil sits in 4 interaction categories. Open any one to see what the group means:

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Fluorouracil through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Fluorouracil through this category.

5-Fluorouracil 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Fluorouracil through this category.

Antineoplastics 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Fluorouracil through this category.

About Fluorouracil

Fluorouracil Injection is a chemotherapy medicine used intravenously to treat adenocarcinoma of the colon and rectum, breast, stomach, and pancreas.

Generic name: Fluorouracil  ·  Brand names: Efudex, Tolak.

See the full Fluorouracil Injection drug information

Related: does Fluorouracil deplete any nutrients?

Fluorouracil has 4 reported nutrient associations in the research literature — see the Fluorouracil nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fluorouracil

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fluorouracil.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Fluorouracil-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Fluorouracil.

Citrus Bergamot Extract 2000 mg by tnvitamins contains Bergamot Bergamot 500 mg by Solaray contains Bergamot Bergamot 375 by ProCaps contains Bergamot Resveratrol Berberine Quercetin Apple Cider Vinegar Acai & Noni by Nutra Harmony contains Bergamot BCT Herbal Oil by Professional Botanicals contains Chenopodium Oil
Pharmacist Counseling Corner

Fluorouracil & Supplements: Common Questions

What supplements interact with Fluorouracil?
More than you might expect — 26 in total, though they are far from equal: 0 are rated major, 23 moderate, and 3 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Bergamot, Chenopodium Oil, Chlorophyll.
Which Fluorouracil supplement interactions are the most serious?
None of the Fluorouracil supplement interactions on file are currently rated major. The most significant are the 23 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Fluorouracil?
Usually yes — most people on Fluorouracil can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Efudex have the same supplement interactions as Fluorouracil?
Yes — Efudex, Tolak all contain Fluorouracil, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Fluorouracil deplete any vitamins or nutrients?
It might — Fluorouracil has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Fluorouracil nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Fluorouracil and my other medications?
This page covers Fluorouracil against supplements and herbal ingredients. Checking Fluorouracil against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fluorouracil Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.