Medication interaction hub

What Supplements Interact with Fluorouracil (IV)?

Fluorouracil (IV) brand name: Fluorouracil. Every interaction below applies to the brands too.

59 Interactions 58 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 16, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fluorouracil (IV)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fluorouracil (IV) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Fluorouracil is an IV chemotherapy medicine, and the supplement list attached to it is manageable for most people once you see the single thread running through it. Nearly all 59 entries are herbs and extracts believed to stimulate the immune system, ashwagandha, astragalus, and medicinal mushroom products among them, and the concern is that revving up immunity could work against the immune-suppressing action that accompanies this drug. Most of that evidence comes from lab and animal studies rather than documented harm in patients, which is why this reads as a watch list rather than a ban list.

A handful of entries behave differently. Fluorouracil can slow the enzyme that breaks down THC, so cannabis products may feel stronger while on treatment. Bring every bottle to your oncology pharmacist during chemotherapy. Nothing here rates major, for what it is worth; 58 entries are moderate and one is minor.

— , Clinical Pharmacist · July 18, 2026

Moderate 58 Minor 1 No known interaction 1,393

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Fluorouracil (IV): Top Interactions at a Glance

The most significant Fluorouracil (IV) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 59 interacting ingredients — plus 1,393 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Fluorouracil (IV) + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible Active Hexose Correlated Compound (ahcc) + Fluorouracil (IV)i

Theoretically, taking AHCC might decrease the effects of immunosuppressant drugs.

Read the full interaction Moderate Likelihood Possible Alfalfa + Fluorouracil (IV)i

Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible American Ginseng + Fluorouracil (IV)i

Theoretically, American ginseng use might interfere with immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible Andrographis + Fluorouracil (IV)i

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Fluorouracil (IV)i

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.

Read the full interaction Moderate Likelihood Possible Astragalus + Fluorouracil (IV)i

Theoretically, astragalus might interfere with immunosuppressive therapy.

Read the full interaction
The complete list

Every Supplement Checked Against Fluorouracil (IV)

All 1,452 ingredients in our database, ranked by severity — 59 with a Fluorouracil (IV) interaction on file and 1,393 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fluorouracil (IV)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Fermented Wheat Germ Extract with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fermented wheat germ extract might decrease the effects of immunosuppressants.

Full Fermented Wheat Germ Extract + Fluorouracil (IV) answer

Can you take Folic Acid with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.

Full Folic Acid + Fluorouracil (IV) answer

Can you take Fulvic Acid with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.

Full Fulvic Acid + Fluorouracil (IV) answer

Can you take Galacto-oligosaccharides (gos) with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, GOS might reduce the effects of immunosuppressants.

Full Galacto-oligosaccharides (gos) + Fluorouracil (IV) answer

Can you take Glyconutrients with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that glyconutrients stimulate certain immune responses.

Full Glyconutrients + Fluorouracil (IV) answer

Can you take Greater Celandine with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that taking a specific semi-synthetic derivative of the greater celandine constituent chelidonine (Uk...

Full Greater Celandine + Fluorouracil (IV) answer

Can you take Green Tea with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of green tea might increase the effects and side effects of 5-fluorouracil.

Full Green Tea + Fluorouracil (IV) answer

Can you take Ipriflavone with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function.

Full Ipriflavone + Fluorouracil (IV) answer

Can you take Jiaogulan with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.

Full Jiaogulan + Fluorouracil (IV) answer

Can you take Kefir with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kefir might increase the risk of bacterial and yeast infections in patients taking immunosuppressants.

Full Kefir + Fluorouracil (IV) answer

Can you take Larch Arabinogalactan with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.

Full Larch Arabinogalactan + Fluorouracil (IV) answer

Can you take Limonene with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9).

Full Limonene + Fluorouracil (IV) answer

Can you take Lion's Mane Mushroom with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.

Full Lion's Mane Mushroom + Fluorouracil (IV) answer

Can you take Mace with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that mace lignans can suppress immune function.

Full Mace + Fluorouracil (IV) answer

Can you take Maritime Pine with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.

Full Maritime Pine + Fluorouracil (IV) answer

Can you take Melatonin with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might interfere with immunosuppressive therapy.

Full Melatonin + Fluorouracil (IV) answer

Can you take Neem with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem might decrease the effectiveness of immunosuppressants.

Full Neem + Fluorouracil (IV) answer

Can you take Panax Ginseng with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng use might interfere with immunosuppressive therapy.

Full Panax Ginseng + Fluorouracil (IV) answer

Can you take Picrorhiza with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Picrorhiza seems to have immunostimulating activity.

Full Picrorhiza + Fluorouracil (IV) answer

Can you take Quillaia with Fluorouracil (IV)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of quillaia with immunosuppressant drugs might decrease the effectiveness of these drugs.

Full Quillaia + Fluorouracil (IV) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fluorouracil (IV) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fluorouracil (IV), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fluorouracil (IV) sits in 3 interaction categories. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Fluorouracil (IV) through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Fluorouracil (IV) through this category.

5-Fluorouracil 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Fluorouracil (IV) through this category.

Related: does Fluorouracil (IV) deplete any nutrients?

Fluorouracil (IV) has 2 reported nutrient associations in the research literature — see the Fluorouracil (IV) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fluorouracil (IV)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fluorouracil (IV).

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Pharmacist Counseling Corner

Fluorouracil (IV) & Supplements: Common Questions

What supplements interact with Fluorouracil (IV)?
In our interaction database, 59 supplement and herbal ingredients have an interaction with Fluorouracil (IV) on file — 0 rated major, 58 moderate, and 1 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Active Hexose Correlated Compound (ahcc), Alfalfa, American Ginseng.
Which Fluorouracil (IV) supplement interactions are the most serious?
None of the Fluorouracil (IV) supplement interactions on file are currently rated major. The most significant are the 58 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Fluorouracil (IV)?
That depends entirely on which supplement. The honest answer for Fluorouracil (IV) is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Fluorouracil have the same supplement interactions as Fluorouracil (IV)?
Yes — Fluorouracil all contain Fluorouracil (IV), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Fluorouracil (IV) deplete any vitamins or nutrients?
It might — Fluorouracil (IV) has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Fluorouracil (IV) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Fluorouracil (IV) and my other medications?
This page covers Fluorouracil (IV) against supplements and herbal ingredients. Checking Fluorouracil (IV) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 16, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.