Medication interaction hub

What Supplements Interact with Fluticasone, Salmeterol?

Fluticasone, Salmeterol brand name: Advair Diskus. Every interaction below applies to the brands too.

141 Interactions 7 Major 105 Moderate 29 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fluticasone, Salmeterol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fluticasone, Salmeterol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Advair Diskus (fluticasone and salmeterol) pairs an inhaled steroid with a long-acting bronchodilator for asthma and COPD, and its supplement list deserves genuine vigilance, with seven major-rated entries sitting at the top. Most of the 141 ingredients on file, 121 of them, act on the CYP3A4 enzyme that clears these drugs. Grapefruit can push levels up and raise the chance of side effects, while St. John's wort can push them down and quietly weaken the inhaler.

The other serious cluster is thirteen ingredients, ephedra among them, that can prolong the QT interval, a heart-rhythm measurement salmeterol can also stretch, and stacking the two raises the risk of dangerous arrhythmias. Milder but far more common are fifteen caffeine sources (coffee, teas, guarana) that can amplify salmeterol's stimulant side and leave the heart pounding. Of the full list, 105 entries are moderate and 29 minor, but the seven majors are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 105 Minor 29 No known interaction 1,311

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Fluticasone, Salmeterol: Top Interactions at a Glance

The Fluticasone, Salmeterol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 141 interacting ingredients — plus 1,311 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Fluticasone, Salmeterol Combinations Today

The Fluticasone, Salmeterol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Devil's Claw + Fluticasone, Salmeteroli

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Horny Goat Weed + Fluticasone, Salmeteroli

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Lime + Fluticasone, Salmeteroli

Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Read the full interaction Moderate Likelihood Possible Bulbine Natalensis + Fluticasone, Salmeteroli

Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Fluticasone, Salmeteroli

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Arsenic + Fluticasone, Salmeteroli

Arsenic trioxide can prolong the QT interval.

Read the full interaction
The complete list

Every Supplement Checked Against Fluticasone, Salmeterol

All 1,452 ingredients in our database, ranked by severity — 141 with a Fluticasone, Salmeterol interaction on file and 1,311 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fluticasone, Salmeterol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Devil's Claw with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Fluticasone, Salmeterol answer

Can you take Horny Goat Weed with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Fluticasone, Salmeterol answer

Can you take Lime with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Full Lime + Fluticasone, Salmeterol answer

Can you take Bulbine Natalensis with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Fluticasone, Salmeterol answer

Can you take Cesium with Fluticasone, Salmeterol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias an...

Full Cesium + Fluticasone, Salmeterol answer

Can you take Ephedra with Fluticasone, Salmeterol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Full Ephedra + Fluticasone, Salmeterol answer

Can you take Sida Cordifolia with Fluticasone, Salmeterol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Full Sida Cordifolia + Fluticasone, Salmeterol answer

Can you take St. John's Wort with Fluticasone, Salmeterol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Fluticasone, Salmeterol answer

Can you take American Hellebore with Fluticasone, Salmeterol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore, also known as Veratrum viride, contains alkaloids that can potentially prolong the QT interval on an electrocardiogram (...

Full American Hellebore + Fluticasone, Salmeterol answer

Can you take Black Tea with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of black tea might increase cardiac inotropic effects of beta-agonists.

Full Black Tea + Fluticasone, Salmeterol answer

Can you take Caffeine with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Full Caffeine + Fluticasone, Salmeterol answer

Can you take Cannabidiol (cbd) with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Full Cannabidiol (cbd) + Fluticasone, Salmeterol answer

Can you take Cocoa with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.

Full Cocoa + Fluticasone, Salmeterol answer

Can you take Coffee with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of coffee might increase cardiac inotropic effects of beta-agonists.

Full Coffee + Fluticasone, Salmeterol answer

Can you take Cola Nut with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in cola nut might increase the clinical effects of beta-adrenergic agonists.

Full Cola Nut + Fluticasone, Salmeterol answer

Can you take Green Coffee with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of green coffee might increase cardiac inotropic effects of beta-agonists.

Full Green Coffee + Fluticasone, Salmeterol answer

Can you take Green Tea with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea contains caffeine.

Full Green Tea + Fluticasone, Salmeterol answer

Can you take Guarana with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the clinical effects of beta-adrenergic agonists.

Full Guarana + Fluticasone, Salmeterol answer

Can you take Guggul with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Fluticasone, Salmeterol answer

Can you take Ilex Guayusa with Fluticasone, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of Ilex guayusa might increase cardiac inotropic effects of beta-agonists.

Full Ilex Guayusa + Fluticasone, Salmeterol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fluticasone, Salmeterol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fluticasone, Salmeterol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fluticasone, Salmeterol sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Fluticasone, Salmeterol through this category.

Beta-Adrenergic Agonists 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Fluticasone, Salmeterol through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Fluticasone, Salmeterol through this category.

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Take a Supplement Product? Check the Whole Bottle Against Fluticasone, Salmeterol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fluticasone, Salmeterol.

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Pharmacist Counseling Corner

Fluticasone, Salmeterol & Supplements: Common Questions

What supplements interact with Fluticasone, Salmeterol?
Our database currently documents 141 ingredients with a known Fluticasone, Salmeterol interaction (7 major, 105 moderate, 29 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 141. The highest-ranked right now: Grapefruit, Arsenic, Cesium.
Which Fluticasone, Salmeterol supplement interactions are the most serious?
Focus on the major group: Grapefruit, Arsenic, Cesium, Ephedra and Sida Cordifolia, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Fluticasone, Salmeterol?
Plenty of supplements coexist fine with Fluticasone, Salmeterol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Advair Diskus have the same supplement interactions as Fluticasone, Salmeterol?
Yes — Advair Diskus all contain Fluticasone, Salmeterol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Fluticasone, Salmeterol and my other medications?
This page covers Fluticasone, Salmeterol against supplements and herbal ingredients. Checking Fluticasone, Salmeterol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.