Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Reserpine?

Hydrochlorothiazide, Reserpine brand names: Hydropres, Serpasil-Esidrix, Serpasil-Esidrix #1, Serpasil-Esidrix #2. Every interaction below applies to the brands too.

231 Interactions 10 Major 196 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 27, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Reserpine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Reserpine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hydrochlorothiazide with reserpine (Hydropres, Serpasil-Esidrix) attacks high blood pressure two ways at once, and its interaction list is long enough, 231 supplements with ten rated major, that I'd approach it with real care rather than a shrug. Most of these either add to the pressure drop or, like tyramine, fight it, and dozens more compound the water pill's pull on potassium and fluid.

Calcium is the everyday item to know, since the thiazide half holds calcium in the body and large doses can push levels dangerously high and strain the kidneys. Activated charcoal can soak up the medication itself, and twenty ingredients layer extra sun sensitivity on top of the drug's own. Of the rest, 196 rate moderate and 25 minor, so read the major entries first, then check whatever you swallow daily against the list below.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 196 Minor 25 No known interaction 1,221

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrochlorothiazide, Reserpine: Top Interactions at a Glance

The Hydrochlorothiazide, Reserpine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 231 interacting ingredients — plus 1,221 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrochlorothiazide, Reserpine Combinations Today

The Hydrochlorothiazide, Reserpine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Bridelia + Hydrochlorothiazide, Reserpinei

Animal research suggests that Bridelia extracts decrease arterial pressure.

Read the full interaction Moderate Likelihood Possible Black Hellebore + Hydrochlorothiazide, Reserpinei

Theoretically, concomitant use of potassium depleting diuretics and black hellebore can increase the risk of cardiac glycoside toxicity due to potassium depleti...

Read the full interaction Moderate Likelihood Possible Yerba Mate + Hydrochlorothiazide, Reserpinei

Theoretically, the caffeine in yerba mate might increase the risk of hypokalemia when used concomitantly with other diuretics.

Read the full interaction Moderate Likelihood Possible Black Root + Hydrochlorothiazide, Reserpinei

Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretic...

Read the full interaction Minor Likelihood Possible Stevia + Hydrochlorothiazide, Reserpinei

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Aristolochia + Hydrochlorothiazide, Reserpinei

Aristolochia is nephrotoxic.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Reserpine

All 1,452 ingredients in our database, ranked by severity — 231 with a Hydrochlorothiazide, Reserpine interaction on file and 1,221 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Reserpine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bridelia with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Bridelia extracts decrease arterial pressure.

Full Bridelia + Hydrochlorothiazide, Reserpine answer

Can you take Black Hellebore with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium depleting diuretics and black hellebore can increase the risk of cardiac glycoside toxicity due...

Full Black Hellebore + Hydrochlorothiazide, Reserpine answer

Can you take Yerba Mate with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate might increase the risk of hypokalemia when used concomitantly with other diuretics.

Full Yerba Mate + Hydrochlorothiazide, Reserpine answer

Can you take Black Root with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassiu...

Full Black Root + Hydrochlorothiazide, Reserpine answer

Can you take Stevia with Hydrochlorothiazide, Reserpine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.

Full Stevia + Hydrochlorothiazide, Reserpine answer

Can you take Tragacanth with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Hydrochlorothiazide, Reserpine answer

Can you take Tree Turmeric with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Tree Turmeric + Hydrochlorothiazide, Reserpine answer

Can you take Tribulus with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Hydrochlorothiazide, Reserpine answer

Can you take Uzara with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassi...

Full Uzara + Hydrochlorothiazide, Reserpine answer

Can you take Vitamin B6 with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Hydrochlorothiazide, Reserpine answer

Can you take Wahoo with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics with wahoo can increase the risk of cardiac glycoside toxicity due to potass...

Full Wahoo + Hydrochlorothiazide, Reserpine answer

Can you take Wallflower with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and wallflower can increase the risk of cardiac glycoside toxicity due to po...

Full Wallflower + Hydrochlorothiazide, Reserpine answer

Can you take White Horehound with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that taking white horehound extract lowers blood pressure.

Full White Horehound + Hydrochlorothiazide, Reserpine answer

Can you take American Ivy with Hydrochlorothiazide, Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The berries of American ivy contain up to 2% oxalic acid, which can be toxic because it has the potential to cause kidney failure by precipi...

Full American Ivy + Hydrochlorothiazide, Reserpine answer

Can you take Thyroid Extract with Hydrochlorothiazide, Reserpine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Hydrochlorothiazide, Reserpine answer

Can you take Agar with Hydrochlorothiazide, Reserpine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Hydrochlorothiazide, Reserpine answer

Can you take Algin with Hydrochlorothiazide, Reserpine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Hydrochlorothiazide, Reserpine answer

Can you take American Spikenard with Hydrochlorothiazide, Reserpine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. American spikenard is purported to have diaphoretic properties.

Full American Spikenard + Hydrochlorothiazide, Reserpine answer

Can you take Beet with Hydrochlorothiazide, Reserpine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.

Full Beet + Hydrochlorothiazide, Reserpine answer

Can you take Birch with Hydrochlorothiazide, Reserpine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, birch might interfere with diuretic therapy.

Full Birch + Hydrochlorothiazide, Reserpine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Reserpine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Reserpine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Reserpine sits in 10 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Reserpine through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Reserpine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Reserpine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Reserpine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Reserpine through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Reserpine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Reserpine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Reserpine through this category.

Alpha-Adrenergic Antagonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Hydrochlorothiazide, Reserpine through this category.

Reserpine (Raudixin, Others) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Hydrochlorothiazide, Reserpine through this category.

Related: does Hydrochlorothiazide, Reserpine deplete any nutrients?

Hydrochlorothiazide, Reserpine has 36 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Reserpine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Reserpine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Reserpine.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Reserpine & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Reserpine?
Our database currently documents 231 ingredients with a known Hydrochlorothiazide, Reserpine interaction (10 major, 196 moderate, 25 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 231. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Reserpine supplement interactions are the most serious?
The 10 major-rated combinations — led by American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Reserpine?
Plenty of supplements coexist fine with Hydrochlorothiazide, Reserpine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Hydropres have the same supplement interactions as Hydrochlorothiazide, Reserpine?
Yes — Hydropres, Serpasil-Esidrix, Serpasil-Esidrix #1, Serpasil-Esidrix #2 all contain Hydrochlorothiazide, Reserpine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Reserpine deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Reserpine has 36 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Reserpine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Reserpine and my other medications?
This page covers Hydrochlorothiazide, Reserpine against supplements and herbal ingredients. Checking Hydrochlorothiazide, Reserpine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 27, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.