Cod Liver Oil - Hydrochlorothiazide, Reserpine Interaction
Herbal: Cod Liver Oil
Drug: Hydrochlorothiazide, Reserpine
Brand names:
Hydropres, Serpasil-Esidrix, Serpasil-Esidrix #1, Serpasil-Esidrix #2
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Hydrochlorothiazide, Reserpine is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.
Cod liver oil can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
- Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
- Jensen T, Stender S, Goldstein K, et al. Partial normalization by dietary cod-liver oil of increased microvascular albumin leakage in patients with insulin-dependent diabetes and albuminuria. N Engl J Med 1989;321:1572-7.
Cod Liver Oil Overview
Cod liver oil is derived from the liver of the Atlantic cod fish. It is a rich source of omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as vitamins A and D.
Cod liver oil is used as a dietary supplement to provide the health benefits of omega-3 fatty acids and vitamins A and D. Omega-3 fatty acids are important for maintaining heart health and can help to reduce inflammation, lower blood pressure and triglyceride levels, and may decrease the risk of heart disease.
While Cod liver oil and fish oil are both sources of EPA and DHA, there are some key differences between the two. For example, cod liver oil is derived from the liver of the Atlantic cod fish, while fish oil is typically derived from the body tissue of oily fish such as salmon, sardines, and anchovies.
Additionally, cod liver oil generally has a stronger fishy taste and smell than fish oil due to its liver source.
Cod Liver Oil - More Interactions
Cod Liver Oil interacts with 370 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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